TY - JOUR
T1 - Wilms tumour surveillance in at-risk children
T2 - Literature review and recommendations from the SIOP-Europe Host Genome Working Group and SIOP Renal Tumour Study Group
AU - Hol, Janna A
AU - Jewell, Rosalyn
AU - Chowdhury, Tanzina
AU - Duncan, Catriona
AU - Nakata, Kayo
AU - Oue, Takaharu
AU - Gauthier-Villars, Marion
AU - Littooij, Annemieke S
AU - Kaneko, Yasuhiko
AU - Graf, Norbert
AU - Bourdeaut, Franck
AU - van den Heuvel-Eibrink, Marry M
AU - Pritchard-Jones, Kathy
AU - Maher, Eamonn R
AU - Kratz, Christian P
AU - Jongmans, Marjolijn C J
PY - 2021/8
Y1 - 2021/8
N2 - Since previous consensus-based Wilms tumour (WT) surveillance guidelines were published, novel genes and syndromes associated with WT risk have been identified, and diagnostic molecular tests for previously known syndromes have improved. In view of this, the International Society of Pediatric Oncology (SIOP)-Europe Host Genome Working Group and SIOP Renal Tumour Study Group hereby present updated WT surveillance guidelines after an extensive literature review and international consensus meetings. These guidelines are for use by clinical geneticists, pediatricians, pediatric oncologists and radiologists involved in the care of children at risk of WT. Additionally, we emphasise the need to register all patients with a cancer predisposition syndrome in national or international databases, to enable the development of better tumour risk estimates and tumour surveillance programs in the future.
AB - Since previous consensus-based Wilms tumour (WT) surveillance guidelines were published, novel genes and syndromes associated with WT risk have been identified, and diagnostic molecular tests for previously known syndromes have improved. In view of this, the International Society of Pediatric Oncology (SIOP)-Europe Host Genome Working Group and SIOP Renal Tumour Study Group hereby present updated WT surveillance guidelines after an extensive literature review and international consensus meetings. These guidelines are for use by clinical geneticists, pediatricians, pediatric oncologists and radiologists involved in the care of children at risk of WT. Additionally, we emphasise the need to register all patients with a cancer predisposition syndrome in national or international databases, to enable the development of better tumour risk estimates and tumour surveillance programs in the future.
KW - Europe
KW - Genomics/methods
KW - Humans
KW - Wilms Tumor/epidemiology
UR - https://www.sciencedirect.com/science/article/pii/S0959804921003221?via%3Dihub
U2 - 10.1016/j.ejca.2021.05.014
DO - 10.1016/j.ejca.2021.05.014
M3 - Review article
C2 - 34134020
SN - 0961-5423
VL - 153
SP - 51
EP - 63
JO - European Journal of Cancer Care
JF - European Journal of Cancer Care
ER -