Zebrafish as a model to investigate the CRH axis and interactions with DISC1

Helen Eachus, Soojin Ryu, Marysia Placzek, Jonathan Wood*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Release of corticotropin-releasing hormone (CRH) from CRH neurons activates the hypothalamo–pituitary–adrenal (HPA) axis, one of the main physiological stress response systems. Complex feedback loops operate in the HPA axis and understanding the neurobiological mechanisms regulating CRH neurons is of great importance in the context of stress disorders. In this article, we review how in vivo studies in zebrafish have advanced knowledge of the neurobiology of CRH neurons. Disrupted-in-schizophrenia 1 (DISC1) mutant zebrafish have blunted stress responses and can be used to model human stress disorders. We propose that DISC1 influences the development and functioning of CRH neurons as a mechanism linking DISC1 to psychiatric disorders.

Original languageEnglish
Article number100383
JournalCurrent Opinion in Endocrine and Metabolic Research
Early online date29 Aug 2022
Publication statusPublished - Oct 2022


  • CRF
  • CRH
  • DISC1
  • HPA axis
  • HPI axis
  • Hypothalamus
  • Zebrafish


Dive into the research topics of 'Zebrafish as a model to investigate the CRH axis and interactions with DISC1'. Together they form a unique fingerprint.

Cite this