Barrel Cortex as a Model System for Understanding the Molecular, Structural, and Functional Basis of Cortical Plasticity

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In this chapter we cover the methodology for molecular, synaptic, cellular, and systems level studies of plasticity in the barrel cortex. The text is organized into four main sections. Section 1 covers methods of inducing plasticity in the barrel cortex as well as how to stimulate the whiskers in a standard way. Section 2 covers extracellular recording for systems level measures of plasticity; section 3 describes the methodology of intracellular recording in vivo for cellular level measures of plasticity, and finally, section 4 covers imaging methods used in understanding the structural plasticity of the synapse and its relationship to functional plasticity.

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Publication date29 Aug 2019
Publication titleHandbook of Behavioral Neuroscience
Number of pages24
Original languageEnglish

Publication series

NameHandbook of Behavioral Neuroscience
ISSN (Print)1569-7339


  • Cortical circuit, LTD, LTP, Spine dynamics, Synaptic plasticity, Synaptic scaling

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