Barrel Cortex as a Model System for Understanding the Molecular, Structural, and Functional Basis of Cortical Plasticity

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Abstract

In this chapter we cover the methodology for molecular, synaptic, cellular, and systems level studies of plasticity in the barrel cortex. The text is organized into four main sections. Section 1 covers methods of inducing plasticity in the barrel cortex as well as how to stimulate the whiskers in a standard way. Section 2 covers extracellular recording for systems level measures of plasticity; section 3 describes the methodology of intracellular recording in vivo for cellular level measures of plasticity, and finally, section 4 covers imaging methods used in understanding the structural plasticity of the synapse and its relationship to functional plasticity.

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Publication date29 Aug 2019
Publication titleHandbook of Behavioral Neuroscience
Pages189-212
Number of pages24
Volume28
Original languageEnglish

Publication series

NameHandbook of Behavioral Neuroscience
Volume28
ISSN (Print)1569-7339

    Keywords

  • Cortical circuit, LTD, LTP, Spine dynamics, Synaptic plasticity, Synaptic scaling

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