Close contact fluctuations: the seeding of signalling domains in the immunological synapse

Amit K. Chattopadhyay, Nigel J. Burroughs

    Research output: Contribution to journalArticlepeer-review

    Abstract

    We analyse the size and density of thermally induced regions of close contact in cell : cell contact interfaces within a harmonic potential approximation, estimating these regions to be below one-tenth of a micron across. Our calculations indicate that as the distance between the close contact threshold depth and the mean membrane-membrane separation increases, the density of close contact patches decreases exponentially while there is only a minimal variation in their mean size. The technique developed can be used to calculate the probability of first crossing in reflection symmetry violating systems. © Europhysics Letters Association.
    Original languageEnglish
    Article number48003
    Number of pages5
    JournalEurophysics Letters
    Volume77
    Issue number4
    DOIs
    Publication statusPublished - 5 Feb 2007

    Bibliographical note

    © EPLA, 2007

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