Dapsone hydroxylamine induces premature removal of human erythrocytes by membrane reorganization and antibody binding

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Authors

  • Luciana Bordin
  • Cristina Fiore
  • Francesco Zen
  • Michael D Coleman
  • Eugenio Ragazzi
  • Giulio Clari

Research units

Abstract

N-hydroxylation of dapsone leads to the formation of the toxic hydroxylamines responsible for the clinical methaemoglobinaemia associated with dapsone therapy. Dapsone has been associated with decreased lifespan of erythrocytes, with consequences such as anaemia and morbidity in patients treated with dapsone for malaria. Here, we investigated how dapsone and/or its hydroxylamine derivative (DDS-NHOH) induced erythrocyte membrane alterations that could lead to premature cell removal.

Details

Original languageEnglish
Pages (from-to)1186-1199
Number of pages14
JournalBritish Journal of Pharmacology
Volume161
Issue number5
DOIs
Publication statusPublished - Nov 2010

    Keywords

  • erythrocyte anion exchange protein 1, anti-infective agents, antibodies, dapsone, drug dose-response relationship, erythrocyte membrane, erythrocytes, humans, immunoglobulin G, male, middle aged, phosphorylation, time factors, tyrosine

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