Potential role of CXCL10/CXCR3 signaling in the development of morphine tolerance in periaqueductal gray

Wei Wang; Yawen Peng; Hui Yang; Huilian Bu; Genhua Guo; Daiqiang Liu; Bin Shu; Xuebi Tian; Ailin Luo; Xuming Zhang; Feng Gao

doi:10.1016/j.npep.2017.07.004

Potential role of CXCL10/CXCR3 signaling in the development of morphine tolerance in periaqueductal gray

Wei Wang, Yawen Peng, Hui Yang, Huilian Bu, Genhua Guo, Daiqiang Liu, Bin Shu, Xuebi Tian, Ailin Luo, Xuming Zhang, Feng Gao

College of Health and Life Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Tolerance to morphine antinociception hinders its long-term use in clinical practice. Interaction between neuron and microglia has been proved to play critical role in the mechanism of morphine tolerance, while CXCL10/CXCR3 signaling has been implicated in neuron-glia signaling and morphine analgesia. This study aims to investigate whether CXCL10/CXCR3 signaling in periaqueductal gray (PAG) contributes to the development of morphine tolerance by modulating neuron-microglia interaction. The results showed that the expressions of CXCR3 and CXCL10 were gradually increased in parallel with repeated morphine administration and activation of microglia. CXCR3 was co-localized with neuronal marker NeuN, while CXCL10 was derived from microglia. Microglia inhibitor minocycline significantly attenuated the expression of CXCL10, besides, both minocycline and CXCR3 inhibitor alleviated the development of morphine tolerance. Taken together, our study provided the evidence that CXCL10/CXCR3 signaling in PAG is involved in the development of morphine analgesic tolerance via neuron-microglia interaction.

Original language	English
Pages (from-to)	120-127
Journal	Neuropeptides
Volume	65
Early online date	24 Jul 2017
DOIs	https://doi.org/10.1016/j.npep.2017.07.004
Publication status	Published - 1 Oct 2017

Bibliographical note

Keywords

chemokine
CXCL10
CXCR3
morphine tolerance

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10.1016/j.npep.2017.07.004

Potential role of CXCL10 CXCR3 signaling in the development of morphine tolerance
© 2017, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
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title = "Potential role of CXCL10/CXCR3 signaling in the development of morphine tolerance in periaqueductal gray",

abstract = "Tolerance to morphine antinociception hinders its long-term use in clinical practice. Interaction between neuron and microglia has been proved to play critical role in the mechanism of morphine tolerance, while CXCL10/CXCR3 signaling has been implicated in neuron-glia signaling and morphine analgesia. This study aims to investigate whether CXCL10/CXCR3 signaling in periaqueductal gray (PAG) contributes to the development of morphine tolerance by modulating neuron-microglia interaction. The results showed that the expressions of CXCR3 and CXCL10 were gradually increased in parallel with repeated morphine administration and activation of microglia. CXCR3 was co-localized with neuronal marker NeuN, while CXCL10 was derived from microglia. Microglia inhibitor minocycline significantly attenuated the expression of CXCL10, besides, both minocycline and CXCR3 inhibitor alleviated the development of morphine tolerance. Taken together, our study provided the evidence that CXCL10/CXCR3 signaling in PAG is involved in the development of morphine analgesic tolerance via neuron-microglia interaction.",

keywords = "chemokine, CXCL10, CXCR3, morphine tolerance",

author = "Wei Wang and Yawen Peng and Hui Yang and Huilian Bu and Genhua Guo and Daiqiang Liu and Bin Shu and Xuebi Tian and Ailin Luo and Xuming Zhang and Feng Gao",

note = "{\textcopyright} 2017, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ ",

year = "2017",

month = oct,

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doi = "10.1016/j.npep.2017.07.004",

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T1 - Potential role of CXCL10/CXCR3 signaling in the development of morphine tolerance in periaqueductal gray

AU - Wang, Wei

AU - Peng, Yawen

AU - Yang, Hui

AU - Bu, Huilian

AU - Guo, Genhua

AU - Liu, Daiqiang

AU - Shu, Bin

AU - Tian, Xuebi

AU - Luo, Ailin

AU - Zhang, Xuming

AU - Gao, Feng

PY - 2017/10/1

Y1 - 2017/10/1

N2 - Tolerance to morphine antinociception hinders its long-term use in clinical practice. Interaction between neuron and microglia has been proved to play critical role in the mechanism of morphine tolerance, while CXCL10/CXCR3 signaling has been implicated in neuron-glia signaling and morphine analgesia. This study aims to investigate whether CXCL10/CXCR3 signaling in periaqueductal gray (PAG) contributes to the development of morphine tolerance by modulating neuron-microglia interaction. The results showed that the expressions of CXCR3 and CXCL10 were gradually increased in parallel with repeated morphine administration and activation of microglia. CXCR3 was co-localized with neuronal marker NeuN, while CXCL10 was derived from microglia. Microglia inhibitor minocycline significantly attenuated the expression of CXCL10, besides, both minocycline and CXCR3 inhibitor alleviated the development of morphine tolerance. Taken together, our study provided the evidence that CXCL10/CXCR3 signaling in PAG is involved in the development of morphine analgesic tolerance via neuron-microglia interaction.

AB - Tolerance to morphine antinociception hinders its long-term use in clinical practice. Interaction between neuron and microglia has been proved to play critical role in the mechanism of morphine tolerance, while CXCL10/CXCR3 signaling has been implicated in neuron-glia signaling and morphine analgesia. This study aims to investigate whether CXCL10/CXCR3 signaling in periaqueductal gray (PAG) contributes to the development of morphine tolerance by modulating neuron-microglia interaction. The results showed that the expressions of CXCR3 and CXCL10 were gradually increased in parallel with repeated morphine administration and activation of microglia. CXCR3 was co-localized with neuronal marker NeuN, while CXCL10 was derived from microglia. Microglia inhibitor minocycline significantly attenuated the expression of CXCL10, besides, both minocycline and CXCR3 inhibitor alleviated the development of morphine tolerance. Taken together, our study provided the evidence that CXCL10/CXCR3 signaling in PAG is involved in the development of morphine analgesic tolerance via neuron-microglia interaction.

KW - chemokine

KW - CXCL10

KW - CXCR3

KW - morphine tolerance

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Potential role of CXCL10/CXCR3 signaling in the development of morphine tolerance in periaqueductal gray

Abstract

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Keywords

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