The effects of RAMPs upon cell signalling

Sarah J. Routledge; Graham Ladds; David R. Poyner

doi:10.1016/j.mce.2017.03.033

The effects of RAMPs upon cell signalling

Sarah J. Routledge^*, Graham Ladds, David R. Poyner

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

G protein-coupled receptors (GPCRs) play a vital role in signal transduction. It is now clear that numerous other molecules within the cell and at the cell surface interact with GPCRs to modulate their signalling properties. Receptor activity modifying proteins (RAMPs) are a group of single transmembrane domain proteins which have been predominantly demonstrated to interact with Family B GPCRs, but interactions with Family A and C receptors have recently begun to emerge. These interactions can influence cell surface expression, ligand binding preferences and G protein-coupling, thus modulating GPCR signal transduction. There is still a great deal of research to be conducted into the effects of RAMPs on GPCR signalling; their effects upon Family B GPCRs are still not fully documented, in addition to their potential interactions with Family A and C GPCRs. New interactions could have a significant impact on the development of therapeutics.

Original language	English
Pages (from-to)	12-20
Number of pages	9
Journal	Molecular and Cellular Endocrinology
Volume	449
Early online date	5 Apr 2017
DOIs	https://doi.org/10.1016/j.mce.2017.03.033
Publication status	Published - 5 Jul 2017

Bibliographical note

© 2017, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/

Funding: BBSRC grants BB/M00015X/1 and BB/M000176/1.

Keywords

receptor activity modifying protein 1
G protein-coupled receptor
signalling
trafficking
coupling

Access to Document

10.1016/j.mce.2017.03.033

Effects of RAMPs upon cell signalling
© 2017, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ Funding: BBSRC grants BB/M00015X/1 and BB/M000176/1
Accepted author manuscript, 9.72 MBLicence: CC BY-NC-ND 3.0

Cite this

@article{ae350191a03648f690467f8f448fc2bc,

title = "The effects of RAMPs upon cell signalling",

abstract = "G protein-coupled receptors (GPCRs) play a vital role in signal transduction. It is now clear that numerous other molecules within the cell and at the cell surface interact with GPCRs to modulate their signalling properties. Receptor activity modifying proteins (RAMPs) are a group of single transmembrane domain proteins which have been predominantly demonstrated to interact with Family B GPCRs, but interactions with Family A and C receptors have recently begun to emerge. These interactions can influence cell surface expression, ligand binding preferences and G protein-coupling, thus modulating GPCR signal transduction. There is still a great deal of research to be conducted into the effects of RAMPs on GPCR signalling; their effects upon Family B GPCRs are still not fully documented, in addition to their potential interactions with Family A and C GPCRs. New interactions could have a significant impact on the development of therapeutics.",

keywords = "receptor activity modifying protein 1, G protein-coupled receptor, signalling, trafficking, coupling",

author = "Routledge, {Sarah J.} and Graham Ladds and Poyner, {David R.}",

note = "{\textcopyright} 2017, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ Funding: BBSRC grants BB/M00015X/1 and BB/M000176/1.",

year = "2017",

month = jul,

day = "5",

doi = "10.1016/j.mce.2017.03.033",

language = "English",

volume = "449",

pages = "12--20",

journal = "Molecular and Cellular Endocrinology",

publisher = "Elsevier",

}

TY - JOUR

T1 - The effects of RAMPs upon cell signalling

AU - Routledge, Sarah J.

AU - Ladds, Graham

AU - Poyner, David R.

N1 - © 2017, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ Funding: BBSRC grants BB/M00015X/1 and BB/M000176/1.

PY - 2017/7/5

Y1 - 2017/7/5

N2 - G protein-coupled receptors (GPCRs) play a vital role in signal transduction. It is now clear that numerous other molecules within the cell and at the cell surface interact with GPCRs to modulate their signalling properties. Receptor activity modifying proteins (RAMPs) are a group of single transmembrane domain proteins which have been predominantly demonstrated to interact with Family B GPCRs, but interactions with Family A and C receptors have recently begun to emerge. These interactions can influence cell surface expression, ligand binding preferences and G protein-coupling, thus modulating GPCR signal transduction. There is still a great deal of research to be conducted into the effects of RAMPs on GPCR signalling; their effects upon Family B GPCRs are still not fully documented, in addition to their potential interactions with Family A and C GPCRs. New interactions could have a significant impact on the development of therapeutics.

AB - G protein-coupled receptors (GPCRs) play a vital role in signal transduction. It is now clear that numerous other molecules within the cell and at the cell surface interact with GPCRs to modulate their signalling properties. Receptor activity modifying proteins (RAMPs) are a group of single transmembrane domain proteins which have been predominantly demonstrated to interact with Family B GPCRs, but interactions with Family A and C receptors have recently begun to emerge. These interactions can influence cell surface expression, ligand binding preferences and G protein-coupling, thus modulating GPCR signal transduction. There is still a great deal of research to be conducted into the effects of RAMPs on GPCR signalling; their effects upon Family B GPCRs are still not fully documented, in addition to their potential interactions with Family A and C GPCRs. New interactions could have a significant impact on the development of therapeutics.

KW - receptor activity modifying protein 1

KW - G protein-coupled receptor

KW - signalling

KW - trafficking

KW - coupling

UR - http://www.scopus.com/inward/record.url?scp=85019047821&partnerID=8YFLogxK

U2 - 10.1016/j.mce.2017.03.033

DO - 10.1016/j.mce.2017.03.033

M3 - Article

AN - SCOPUS:85019047821

VL - 449

SP - 12

EP - 20

JO - Molecular and Cellular Endocrinology

JF - Molecular and Cellular Endocrinology

ER -

The effects of RAMPs upon cell signalling

Abstract

Bibliographical note

Keywords

Access to Document

Other files and links

Fingerprint

Cite this