Manoj Upadhya

Dr

    • United Kingdom

    20072019

    Research output per year

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    Personal profile

    Contact Details

    Email: m.upadhya@aston.ac.uk

    Room: MB439

    General

    I joined Aston School of Life and Health Sciences in April 2019, having spent the previous 1.5 years as Research Associate at Neuroscience and Neuronal Connectivity Laboratory, Indian Institute of Science Education and Research (IISER), Pune, India. Prior to that, I spent 2 years at Sunpharma Advanced Research Company Ltd., India and was Senior Executive Scientist in Drug Discovery Biology Unit. I also served as Assistant Professor in Pharmacology at SKB College of Pharmacy, RTM Nagpur University, India for 2.5 years

    Employment

    • April, 2019 – date: Postdoctoral Research Associate, Aston School of Life and Health Sciences, Aston University.
    • November, 2017 – April, 2019: Postdoctoral Research Associate, Indian Institute of Science Education and Research (IISER), Pune, India.
    • November, 2015 – November, 2017: Senior Executive Scientist, Drug Discovery Biology, Sunpharma Advanced Research Company Ltd., Vadodara, India.
    • August, 2013 – November, 2015: Assistant Professor in Pharmacology, SKB College of Pharmacy, New Kamptee, India

    Teaching Activity

    Teaching experience in subjects like Human Anatomy and Physiology, Advanced Physiology and Pathophysiology, Pharmacology and Toxicology, Drug Discovery and Biological Evaluation, Clinical Research, Pharmacoeconomics

    Research Interests

    • I am interested in the behavioural aspects and molecular mechanisms of pain. My research work primarily involves the behavioural and functional assessment, and modulation of TRP ion channels in sensory neurons under physiological and disease conditions, and how they contribute to hyperalgesia.
    • Prior to this assignment, my work was directed towards investigating the physiological and functional role of CART peptide in neurological disorders employing rats and mice as experimental models. I demonstrated that endogenous CART potentiates spatial learning and memory behaviour and modulates the effects of cholinergic agents in the management of Alzheimer’s disease like conditions in rats. I showed that CART in accumbens shell in brain serve as an essential component of the opiod-mesolimbic dopaminergic reward system. Further I studied that CART also process predator induced fear in the neuronal circuitry that operates across the hypothalamo-amygdalar circuit. Later I demonstrated the role of CART as neuroprotective agent in the prevention of Parkinson’s disease and Huntington’s disease since it increased the dopamine content in brain. CART also modulates the neuropathic pain and closely interacts with the glucocorticoids in nerve damage ailments like spinal cord injury. Thus, I concluded that upregulation of endogenous CART system might serve as fruitful strategy in the treatment of a range of pathophysiological conditions and neurodegenerative diseases. This research work has led to several high impact publications in journals like Addiction Biology, Neuropharmacology, Behavioural Brain Research, Brain Research, Peptides, Life Sciences, Neuropeptides, etc.
    • Before joining IISER Pune, I worked with Drug Discovery Biology team at Sun Pharma Advanced Research Company Ltd., India (SPARC), a leading pharmaceutical company.  With SPARC, I served as Lead Scientist for the assessment of molecules in Parkinson's, Alzheimer's and Huntington's diseases. We proposed one SPARC molecule as a drug candidate for Parkinson's disease therapy, and could publish one international patent in WIPO entitled "Treatment for Parkinson's disease".
    • Techniques expertise: Behavioural Pharmacology, Immunohistochemistry, Transcardial perfusions, Neuroanatomy and Brain dissection, Molecular Biology

    Membership of Professional Bodies

    • Life Member, Indian Pharmacological Society (IPS).
    • Life Member, Indian Pharmacy Graduates’ Association (IPGA).
    • Life Member, Society for Neurochemistry India (SNCI).

    Education/Academic qualification

    PhD

    19 Sep 200926 Mar 2013

    Award Date: 26 Mar 2013

    Fingerprint Dive into the research topics where Manoj Upadhya is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

    Research Output

    TREATMENT FOR PARKINSON'S DISEASE

    DAMLE, NITIN. KRISHNAJI., MANDHANE, SANJAY. NANDLALJI., Upadhya, M., MEHETRE, SAMEER. VISHWANATH., CHIDREWAR, GAJANAN. UTTAMRAO., SENGUPTA, PRABAL. & CHITTURI, TRINADHA. RAO., 10 Apr 2019, Patent No. EP3463351, Priority No. IN201621019087 20160602 ; IN201621019185 20160602 ; WO2017IN50224 20170602

    Research output: Patent

    Open Access
  • Neuroprotective effect of agmatine in mouse spinal cord injury model: Modulation by imidazoline receptors

    DIxit, M., Upadhya, M., Taksande, B., Raut, P., Umekar, M. & Kotagale, N., 1 Jul 2018, In : Journal of Natural Science, Biology and Medicine. 9, 2, p. 115-120 6 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • TREATMENT FOR PARKINSON'S DISEASE

    DAMLE, NITIN. KRISHNAJI., MANDHANE, SANJAY. NANDLALJI., Upadhya, M., MEHETRE, SAMEER. VISHWANATH., CHIDREWAR, GAJANAN. UTTAMRAO., SENGUPTA, PRABAL. & CHITTURI, TRINADHA. RAO., 7 Dec 2017, IPC No. A61K 31/44, A61K 31/47, A61P 25/16, Patent No. WO2017208267, 2 Jun 2017, Priority date 2 Jun 2016, Priority No. 201621019087; 201621019185

    Research output: Patent

    Open Access
  • CART modulates the effects of levodopa in rat model of Parkinson’s disease

    Upadhya, M., Shelkar, G. P., Subhedar, N. K. & Kokare, D. M., 15 Mar 2016, In : Behavioural Brain Research. 301, p. 262-272

    Research output: Contribution to journalArticle

  • Neuropeptide Y system in accumbens shell mediates ethanol self-administration in posterior ventral tegmental area: AcbSh NPY in ethanol reward

    Borkar, C. D., Upadhya, M., Shelkar, G. P., Subhedar, N. K. & Kokare, D. M., Jul 2016, In : Addiction biology. 21, 4, p. 766-775

    Research output: Contribution to journalArticle

  • Prizes

    Best Publication in Peer-Reviewed Journal Category

    Manoj Upadhya (Recipient), 23 Oct 2016

    Prize: Prize (including medals and awards)

    Executive Master of Business Administration (EMBA)

    Manoj Upadhya (Recipient), 10 Aug 2015

    Prize: Honorary degree

  • Best Poster Award

    Manoj Upadhya (Recipient), 18 Dec 2013

    Prize: Prize (including medals and awards)

    Gayle A. Olson & Richard D. Olson prize

    Manoj Upadhya (Recipient), 1 Feb 2012

    Prize: National/international honour

  • Prof. Ch. R. K. Murthy Memorial Prize

    Manoj Upadhya (Recipient), 11 Jan 2012

    Prize: Prize (including medals and awards)

  • Activities

    • 4 Invited talk

    Resource Person and Speaker

    Manoj Upadhya (Speaker)
    5 Jan 20137 Jan 2013

    Activity: Talk or presentation typesInvited talk

    Resource Person and Speaker

    Manoj Upadhya (Speaker)
    27 Feb 201028 Feb 2010

    Activity: Talk or presentation typesInvited talk

    Teaching Assistant

    Manoj Upadhya (Speaker)
    27 Jan 200813 Feb 2008

    Activity: Talk or presentation typesInvited talk