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Personal profile

Contact Details

Email: m.upadhya@aston.ac.uk

Room: MB439

General

I joined Aston School of Life and Health Sciences in April 2019, having spent the previous 1.5 years as Research Associate at Neuroscience and Neuronal Connectivity Laboratory, Indian Institute of Science Education and Research (IISER), Pune, India. Prior to that, I spent 2 years at Sunpharma Advanced Research Company Ltd., India and was Senior Executive Scientist in Drug Discovery Biology Unit. I also served as Assistant Professor in Pharmacology at SKB College of Pharmacy, RTM Nagpur University, India for 2.5 years

Employment

  • April, 2019 – date: Postdoctoral Research Associate, Aston School of Life and Health Sciences, Aston University.
  • November, 2017 – April, 2019: Postdoctoral Research Associate, Indian Institute of Science Education and Research (IISER), Pune, India.
  • November, 2015 – November, 2017: Senior Executive Scientist, Drug Discovery Biology, Sunpharma Advanced Research Company Ltd., Vadodara, India.
  • August, 2013 – November, 2015: Assistant Professor in Pharmacology, SKB College of Pharmacy, New Kamptee, India

Teaching Activity

Teaching experience in subjects like Human Anatomy and Physiology, Advanced Physiology and Pathophysiology, Pharmacology and Toxicology, Drug Discovery and Biological Evaluation, Clinical Research, Pharmacoeconomics

Research Interests

  • I am interested in the behavioural aspects and molecular mechanisms of pain. My research work primarily involves the behavioural and functional assessment, and modulation of TRP ion channels in sensory neurons under physiological and disease conditions, and how they contribute to hyperalgesia.
  • Prior to this assignment, my work was directed towards investigating the physiological and functional role of CART peptide in neurological disorders employing rats and mice as experimental models. I demonstrated that endogenous CART potentiates spatial learning and memory behaviour and modulates the effects of cholinergic agents in the management of Alzheimer’s disease like conditions in rats. I showed that CART in accumbens shell in brain serve as an essential component of the opiod-mesolimbic dopaminergic reward system. Further I studied that CART also process predator induced fear in the neuronal circuitry that operates across the hypothalamo-amygdalar circuit. Later I demonstrated the role of CART as neuroprotective agent in the prevention of Parkinson’s disease and Huntington’s disease since it increased the dopamine content in brain. CART also modulates the neuropathic pain and closely interacts with the glucocorticoids in nerve damage ailments like spinal cord injury. Thus, I concluded that upregulation of endogenous CART system might serve as fruitful strategy in the treatment of a range of pathophysiological conditions and neurodegenerative diseases. This research work has led to several high impact publications in journals like Addiction Biology, Neuropharmacology, Behavioural Brain Research, Brain Research, Peptides, Life Sciences, Neuropeptides, etc.
  • Before joining IISER Pune, I worked with Drug Discovery Biology team at Sun Pharma Advanced Research Company Ltd., India (SPARC), a leading pharmaceutical company.  With SPARC, I served as Lead Scientist for the assessment of molecules in Parkinson's, Alzheimer's and Huntington's diseases. We proposed one SPARC molecule as a drug candidate for Parkinson's disease therapy, and could publish one international patent in WIPO entitled "Treatment for Parkinson's disease".
  • Techniques expertise: Behavioural Pharmacology, Immunohistochemistry, Transcardial perfusions, Neuroanatomy and Brain dissection, Molecular Biology

Membership of Professional Bodies

  • Life Member, Indian Pharmacological Society (IPS).
  • Life Member, Indian Pharmacy Graduates’ Association (IPGA).
  • Life Member, Society for Neurochemistry India (SNCI).

Education/Academic qualification

PhD

19 Sep 200926 Mar 2013

Fingerprint Dive into the research topics where Manoj Upadhya is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Amphetamine Medicine & Life Sciences
Cocaine Medicine & Life Sciences
Neuropeptide Y Medicine & Life Sciences
Peptides Medicine & Life Sciences
Morphine Medicine & Life Sciences
Rats Chemical Compounds
Reward Medicine & Life Sciences
Spinal Cord Injuries Medicine & Life Sciences

Research Output 2007 2019

TREATMENT FOR PARKINSON'S DISEASE

DAMLE, NITIN. KRISHNAJI., MANDHANE, SANJAY. NANDLALJI., Upadhya, M., MEHETRE, SAMEER. VISHWANATH., CHIDREWAR, GAJANAN. UTTAMRAO., SENGUPTA, PRABAL. & CHITTURI, TRINADHA. RAO., 10 Apr 2019, Patent No. EP3463351, Priority No. IN201621019087 20160602 ; IN201621019185 20160602 ; WO2017IN50224 20170602

Research output: Patent

Open Access
Hydrogen
Halogens
Patents and inventions
Carbon
Salts

Neuroprotective effect of agmatine in mouse spinal cord injury model: Modulation by imidazoline receptors

DIxit, M., Upadhya, M., Taksande, B., Raut, P., Umekar, M. & Kotagale, N., 1 Jul 2018, 9, 2, p. 115-120 6 p.

Research output: Contribution to journalArticle

Open Access
File
Imidazoline Receptors
Agmatine
Neuroprotective Agents
Spinal Cord Injuries
Modulation

TREATMENT FOR PARKINSON'S DISEASE

DAMLE, NITIN. KRISHNAJI., MANDHANE, SANJAY. NANDLALJI., Upadhya, M., MEHETRE, SAMEER. VISHWANATH., CHIDREWAR, GAJANAN. UTTAMRAO., SENGUPTA, PRABAL. & CHITTURI, TRINADHA. RAO., 7 Dec 2017, IPC No. A61K 31/44, A61K 31/47, A61P 25/16, Patent No. WO2017208267, 2 Jun 2017, Priority date 2 Jun 2016, Priority No. 201621019087; 201621019185

Research output: Patent

Open Access
Hydrogen
Halogens
Patents and inventions
Carbon
Salts

CART modulates the effects of levodopa in rat model of Parkinson’s disease

Upadhya, M., Shelkar, G. P., Subhedar, N. K. & Kokare, D. M., 15 Mar 2016, In : Behavioural Brain Research. 301, p. 262-272

Research output: Contribution to journalArticle

Levodopa
Amphetamine
Cocaine
Parkinson Disease
Substantia Nigra

Neuropeptide Y system in accumbens shell mediates ethanol self-administration in posterior ventral tegmental area: AcbSh NPY in ethanol reward

Borkar, C. D., Upadhya, M., Shelkar, G. P., Subhedar, N. K. & Kokare, D. M., Jul 2016, 21, 4, p. 766-775

Research output: Contribution to journalArticle

Ventral Tegmental Area
Self Administration
Neuropeptide Y
Reward
Ethanol

Prizes

All India Rank 371 out of 11698 in GATE-2005

Manoj Upadhya (Recipient), 15 Mar 2005

Prize: Other distinction

Human resource development
India
Government
Education

Best Paper Award in Pharmacology and Toxicology

Manoj Upadhya (Recipient), 3 Dec 2006

Prize: Prize (including medals and awards)

toxicology
drug
pharmacology
congress

Best Poster Award

Manoj Upadhya (Recipient), 14 Dec 2008

Prize: Prize (including medals and awards)

Best Poster Award

Manoj Upadhya (Recipient), 18 Dec 2013

Prize: Prize (including medals and awards)

Best Publication in Peer-Reviewed Journal Category

Manoj Upadhya (Recipient), 23 Oct 2016

Prize: Prize (including medals and awards)

Activities 2008 2015

  • 4 Invited talk

Resource Person and Speaker

Manoj Upadhya (Speaker)
5 Jan 20137 Jan 2013

Activity: Talk or presentation typesInvited talk

Resource Person and Speaker

Manoj Upadhya (Speaker)
27 Feb 201028 Feb 2010

Activity: Talk or presentation typesInvited talk

Teaching Assistant

Manoj Upadhya (Speaker)
27 Jan 200813 Feb 2008

Activity: Talk or presentation typesInvited talk