3D printing customised stiffness-matched meta-biomaterial with near-zero auxeticity for load-bearing tissue repair

Chameekara T. Wanniarachchi, Arun Arjunan*, Ahmad Baroutaji, Manpreet Singh

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The evolution of meta-biomaterials has opened up exciting new opportunities for mass personalisation of biomedical devices. This research paper details the development of a CoCrMo meta-biomaterial structure that facilitates personalised stiffness-matching while also exhibiting near-zero auxeticity. Using laser powder bed fusion, the porous architecture of the meta-biomaterial was characterised, showing potential for near-zero Poisson's ratio. The study also introduces a novel surrogate model that can predict the porosity ( φ ), yield strength ( σ y ), elastic modulus ( E ), and negative Poisson's ratio ( − υ ) of the meta-biomaterial, which was achieved through prototype testing and numerical modelling. The model was then used to inform a multi-criteria desirability objective, revealing an optimum near-zero − υ of −0.037, with a targeted stiffness of 17.21 GPa. Parametric analysis of the meta-biomaterial showed that it exhibited − υ , φ , σ y and E values ranging from −0.02 to −0.08, 73.63–81.38%, 41–64 MPa, and 9.46–20.6 GPa, respectively. In this study, a surrogate model was developed for the purpose of generating personalised scenarios for the production of bone scaffolds. By utilising this model, it was possible to achieve near-zero − υ and targeted stiffness personalisation. This breakthrough has significant implications for the field of bone tissue engineering and could pave the way for improved patient outcomes. The presented methodology is a powerful tool for the development of biomaterials and biomedical devices that can be 3D printed on demand for load-bearing tissue reconstruction. It has the potential to facilitate the creation of highly tailored and effective treatments for various conditions and injuries, ultimately enhancing patient outcomes.
Original languageEnglish
Article numbere00292
Number of pages16
JournalBioprinting
Volume33
Early online date19 Jun 2023
DOIs
Publication statusPublished - Sept 2023

Bibliographical note

Copyright © 2023 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (https://creativecommons.org/licenses/by/4.0/)

Keywords

  • 3D printing
  • Auxetic bone scaffold
  • Laser powder bed fusion
  • Meta-biomaterials
  • Metamaterials

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