A protocol for producing the maternal low-protein rat model: A tool for preclinical proteomic studies

Dan Ma, Susan E. Ozanne, Paul C. Guest*

*Corresponding author for this work

Research output: Chapter in Book/Published conference outputChapter

Abstract

Epidemiological studies have shown that periods of poor nutrition during pregnancy can lead to an increased risk of metabolic and psychiatric disorders in the offspring. In addition, some individuals with disorders such as schizophrenia show signs of impaired insulin signalling. These findings indicate that there may be a link between metabolism and neuronal function and they also provide supporting evidence for neurodevelopmental origins of mental illness. This chapter gives a detailed protocol for generation of the maternal low-protein (LP) rat model, which leads to metabolic disturbances in the offspring. This model has been used in proteomic studies of several disorders including schizophrenia.
Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
EditorsP. Guest
PublisherSpringer
Pages251-255
Number of pages5
ISBN (Electronic)978-3-319-52479-5
ISBN (Print)978-3-319-52478-8
DOIs
Publication statusPublished - 29 Mar 2017

Publication series

NameAdvances in Experimental Medicine and Biology
Volume974
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

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