An ion-sensitive microelectrode study on the effect of a high concentration of ivermectin on chloride balance in the somatic muscle bag cells of Ascaris suum

H R Parri, M B Djamgoz, L Holden-Dye, R J Walker

Research output: Contribution to journalArticlepeer-review

Abstract

Ivermectin has been shown to increase chloride conductances of invertebrate cells. On the muscle cells of the parasitic nematode Ascaris, ivermectin acts as both a GABA receptor antagonist and a chloride channel opener. In this study, ion-sensitive microelectrodes were used to investigate the effect of ivermectin on intracellular Cl- concentration of the somatic muscle bag cells of Ascaris suum. Incubation of muscle cells with ivermectin (10 microM in 1% dimethyl sulphoxide vehicle for 60 min) increased intracellular Cl- by 2.9 mM or 15% compared to controls (P <0.01, n = 6).
Original languageEnglish
Pages (from-to)421-7
Number of pages7
JournalParasitology
Volume106
Issue number4
Publication statusPublished - May 1993

Keywords

  • Animals
  • Ascaris suum
  • Chlorides
  • Dimethyl Sulfoxide
  • Ions
  • Ivermectin
  • Membrane Potentials
  • Microelectrodes
  • Muscles
  • Sensitivity and Specificity
  • Water-Electrolyte Balance

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