An ultra-sensitive aptasensor on optical fibre for the direct detection of Bisphenol A

Thomas D.P. Allsop, Ronald Neal, Changle Wang, David A Nagel, Anna V. Hine, Philip F. Culverhouse, Juan Diego Ania-Castañón, David J Webb, Simona Scarano, Maria Minunni

Research output: Contribution to journalArticlepeer-review


We present a plasmonic biosensor capable of detecting the presence of bisphenol A in ultralow concentrations, yielding a wavelength shift of 0.15±0.01 nm in response to a solution of 1 fM concentration with limit of detection of 330±70 aM. The biosensing device consists of an array of gold nano-antennae with a total length of 2.3cm that generate coupled localised surface plasmons (cLSPs) and is covalently modified with an aptamer specific for bisphenol A recognition. The array of nanoantennae is fabricated on a lapped section of standard telecommunication optical fibre, allowing for potential multiplexing and its use in remote sensing applications. These results have been achieved without the use of enhancement techniques and therefore the approach allows the direct detection of bisphenol A, a low molecular weight (228 Da) target usually detectable only by indirect detection strategies. Its detection at such levels is a significant step forward in measuring small molecules at ultralow concentrations. Furthermore, this new sensing platform paves the way for the development of portable systems for in-situ agricultural measurements capable of retrieving data on a substance of very high concern at ultra-low concentrations.
Original languageEnglish
Pages (from-to)102-110
Number of pages9
JournalBiosensors and Bioelectronics
Early online date22 Feb 2019
Publication statusPublished - 15 Jun 2019

Bibliographical note

© 2019, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International

Funding: EPSRC EP/J010413 and EP/J01039; MIUR scientific program SIR2014 Scientific Independence of young Researchers (RBSI1455LK).


  • Aptamers
  • Biosensors
  • Bisphenol A
  • Fibre optics
  • Nanostructures
  • Plasmonics


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