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Anna V. Hine



    Research output per year

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    Personal profile


    Hine gained her PhD in Molecular Biology from UMIST in 1992 and her postdoctoral training at Harvard Medical School (PI: Prof Charles C. Richardson). She returned to the UK to take up a lectureship in Molecular Biology at Aston University in 1995. In 2003 she commenced her combined career in academia and innovation with a Medici Fellowship (commercialisation and entrepreneurial training), which was later followed by a secondment to the University's Business Partnership Unit as the School of Life and Health Sciences' Innovation Fellow. She was promoted to Senior Lecturer in 2006, Reader in 2013, Associate Dean in 2015 and Chair in 2018.  The mother of two children, she has worked part time (0.7/0.8 FTE) since 2003.

    Research Interests

    • Protein Engineering
    • Research at the interface between molecular biology and the physical sciences
    • Development of enabling technologies for biomedicines
    • Protein-DNA interactions of Cys2His2 zinc fingers
    • Protein-DNA interactions of single Cys4 zinc fingers

    Hine's research centres on combinatorial, synthetic biology and its application to protein-ligand interactions. She was named the BBSRC Commercial Innovator of the Year 2013; an award made for her successful transfer of her group’s inventions in protein engineering into UK-based Biotech company Isogenica Ltd.  ColibraTM is now being exploited by Isogenica in the production of their highly-diverse synthetic antibody libraries.

    Resulting from numerous multi-disciplinary collaborations, she also has experience of developing novel screens and in exploiting protein-DNA interactions to achieve advances in biotech process engineering.  Her interdisciplinary work has generated several photonic biosensors, a generic technology to deliver and release proteins within mammalian cells and most recently, in an international FET-OPEN project is developing synthetic replacements for monoclonal reagent antibodies.

    Research Projects/Collaborations


    • 2013 BBSRC Commercial Innovator of the Year
    • 2013 Aston Excellence Award for Outstanding Contribution to Innovation and/or Technological Improvement

    Membership of Professional Bodies

    • Fellow of the Royal Society of Biology
    • Member of the Biochemical Society
    • Senior Fellow of the Higher Education Academy


    • 2018-date Professor of Protein Engineering, Aston University
    • 2015-date Associate Dean, Enterprise, Aston University
    • 2013-2018 Reader in Molecular Biology, Aston University
    • 2009-2012 Course Director, MSc Biotechnology, Aston University
    • 2006-2013 Senior Lecturer in Molecular Biology, Aston University
    • 2005-2006 LHS Innovation Fellow, Business Partnership Unit (partial secondment), Aston University
    • 2004-2005 CEO, ProtaMAX Ltd
    • 2003-2004 Medici Fellow (Commercialisation and Entrepreneurial Training)
    • 1995-2006 Lecturer in Molecular Biology, Aston University
    • 1993-94 Research Fellow, Harvard Medical School (PI: Prof. C.C. Richardson)


    • 1989-92 PhD, UMIST (Supervisor: Prof. T.A. Brown)
    • 1986-89 BSc Hons Biochemistry and Applied Molecular Biology (Class I) UMIST (now integrated into the University of Manchester)

    Contact Details

    Telephone: +44 (0) 121 204 3961

    External positions

    Panel Member, EPSRC International Centre to Centre Programme


    Panel Member, BBSRC Impact Accelerator Awards


    Committee Member, BBSRC Follow-on-Fund

    2016 → …

    Panel Member, BBSRC Excellence with Impact




    Technical Expert, EU Eurostars programme

    2009 → …

    Member of EPSRC College

    2006 → …

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    Research Output

    A C-terminal cysteine residue is required for peptide-based inhibition of the NGF/TrkA interaction at nM concentrations: implications for peptide-based analgesics

    Poole, A., Frigotto, L., Smith, M. E., Baar, C., Ivanova-Berndt, G., Jaulent, A., Stace, C., Ullman, C. G. & Hine, A. V., 30 Jan 2019, In : Scientific Reports. 9, 1, 930.

    Research output: Contribution to journalArticle

    Open Access
  • An ultra-sensitive aptasensor on optical fibre for the direct detection of Bisphenol A

    Allsop, T. D. P., Neal, R., Wang, C., Nagel, D. A., Hine, A. V., Culverhouse, P. F., Ania-Castañón, J. D., Webb, D. J., Scarano, S. & Minunni, M., 15 Jun 2019, In : Biosensors and Bioelectronics. 135, p. 102-110 9 p.

    Research output: Contribution to journalArticle

    Open Access
  • ParaMAX: non-degenerative saturation mutagenesis applied to an alpha helical repeat protein

    Wagstaffe, B., Chembath, A., Michel, E., Stark, Y., Plückthun, A. & Hine, A. V., 17 Jul 2019.

    Research output: Contribution to conferencePoster

    PRe-ART: Predictive Reagent Antibody Replacement Technology

    Chembath, A., Wagstaffe, B., Ashraf, M., Michel, E., Stark, Y., Ferruz-Capapey, N., Kynast, J., Höcker, B., Hine, A. V. & Plückthun, A., 18 Nov 2019.

    Research output: Contribution to conferenceAbstract

  • Saturation mutagenesis and precision libraries: the numbers game

    Hine, A. V., Chembath, A., Ferreira Amaral, M., Wagstaffe, B., Stark, Y. & Plückthun, A., 2019.

    Research output: Contribution to conferenceAbstract

  • Datasets

    Real-time kinetic binding studies at attomolar concentrations in solution phase using a single-stage opto-biosensing platform based upon infrared surface plasmons

    Allsop, T. (Creator), Mou, C. (Contributor), Neal, R. (Contributor), Nagel, D. (Contributor), Poole, A. (Contributor), Kalli, K. (Contributor), Hine, A. V. (Contributor), Webb, D. (Contributor), Culverhouse, P. F. (Contributor), Minunni, M. (Contributor), Bennion, I. (Contributor), Tombelli, S. (Contributor) & Mariani, S. (Contributor), Aston Data Explorer, 28 Feb 2017



    BBSRC Follow-on-Fund Committee (External organisation)

    Anna V. Hine (Member)

    Mar 2016Feb 2020

    Activity: Membership typesMembership of council

    Consultant, Isogenica Ltd.

    Anna V. Hine (Advisor)


    Activity: Consultancy typesConsultancy

    International Advisory Board, Thermo Fisher

    Anna V. Hine (Advisor)

    May 2010

    Activity: Consultancy typesConsultancy

    Training placement, funded by the regional council of Languedoc-Roussillon (France).

    Anna V. Hine (Host)

    Apr 2010Jul 2010

    Activity: Other activity typesTypes of External academic engagement - Hosting an academic visitor

    Consultant, Intrexon Inc.

    Anna V. Hine (Advisor)


    Activity: Consultancy typesConsultancy