Anna V. Hine


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Personal profile


Hine gained her PhD in Molecular Biology from UMIST in 1992 and her postdoctoral training at Harvard Medical School (PI: Prof Charles C. Richardson). She returned to the UK to take up a lectureship in Molecular Biology at Aston University in 1995. In 2003 she commenced her combined career in academia and innovation with a Medici Fellowship (commercialisation and entrepreneurial training), which was later followed by a secondment to the University's Business Partnership Unit as the School of Life and Health Sciences' Innovation Fellow. She was promoted to Senior Lecturer in 2006, Reader in 2013, Associate Dean in 2015 and Chair in 2018.  The mother of two children, she has worked part time (0.7/0.8 FTE) since 2003.

Research Interests

  • Protein Engineering
  • Research at the interface between molecular biology and the physical sciences
  • Development of enabling technologies for biomedicines
  • Protein-DNA interactions of Cys2His2 zinc fingers
  • Protein-DNA interactions of single Cys4 zinc fingers

Hine's research centres on combinatorial, synthetic biology and its application to protein-ligand interactions. She was named the BBSRC Commercial Innovator of the Year 2013; an award made for her successful transfer of her group’s inventions in protein engineering into UK-based Biotech company Isogenica Ltd.  ColibraTM is now being exploited by Isogenica in the production of their highly-diverse synthetic antibody libraries.

Resulting from numerous multi-disciplinary collaborations, she also has experience of developing novel screens and in exploiting protein-DNA interactions to achieve advances in biotech process engineering.  Her interdisciplinary work has generated several photonic biosensors, a generic technology to deliver and release proteins within mammalian cells and most recently, in an international FET-OPEN project is developing synthetic replacements for monoclonal reagent antibodies.

Research Projects/Collaborations


  • 2013 BBSRC Commercial Innovator of the Year
  • 2013 Aston Excellence Award for Outstanding Contribution to Innovation and/or Technological Improvement

Membership of Professional Bodies

  • Fellow of the Royal Society of Biology
  • Member of the Biochemical Society
  • Senior Fellow of the Higher Education Academy


  • 2018-date Professor of Protein Engineering, Aston University
  • 2015-date Associate Dean, Enterprise, Aston University
  • 2013-2018 Reader in Molecular Biology, Aston University
  • 2009-2012 Course Director, MSc Biotechnology, Aston University
  • 2006-2013 Senior Lecturer in Molecular Biology, Aston University
  • 2005-2006 LHS Innovation Fellow, Business Partnership Unit (partial secondment), Aston University
  • 2004-2005 CEO, ProtaMAX Ltd
  • 2003-2004 Medici Fellow (Commercialisation and Entrepreneurial Training)
  • 1995-2006 Lecturer in Molecular Biology, Aston University
  • 1993-94 Research Fellow, Harvard Medical School (PI: Prof. C.C. Richardson)


  • 1989-92 PhD, UMIST (Supervisor: Prof. T.A. Brown)
  • 1986-89 BSc Hons Biochemistry and Applied Molecular Biology (Class I) UMIST (now integrated into the University of Manchester)

Contact Details

Telephone: +44 (0) 121 204 3961

External positions

Panel Member, EPSRC International Centre to Centre Programme


Panel Member, BBSRC Impact Accelerator Awards


Committee Member, BBSRC Follow-on-Fund

2016 → …

Panel Member, BBSRC Excellence with Impact




Technical Expert, EU Eurostars programme

2009 → …

Member of EPSRC College

2006 → …

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Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1994 2019

A C-terminal cysteine residue is required for peptide-based inhibition of the NGF/TrkA interaction at nM concentrations: implications for peptide-based analgesics

Poole, A., Frigotto, L., Smith, M. E., Baar, C., Ivanova-Berndt, G., Jaulent, A., Stace, C., Ullman, C. G. & Hine, A. V., 30 Jan 2019, In : Scientific Reports. 9, 1, 930.

Research output: Contribution to journalArticle

Open Access
Nerve Growth Factor
trkA Receptor

An ultra-sensitive aptasensor on optical fibre for the direct detection of Bisphenol A

Allsop, T. D. P., Neal, R., Wang, C., Nagel, D. A., Hine, A. V., Culverhouse, P. F., Ania-Castañón, J. D., Webb, D. J., Scarano, S. & Minunni, M., 15 Jun 2019, In : Biosensors and Bioelectronics. 135, p. 102-110 9 p.

Research output: Contribution to journalArticle

Optical Fibers
Optical fibers

ParaMAX: non-degenerative saturation mutagenesis applied to an alpha helical repeat protein

Wagstaffe, B., Chembath, A., Michel, E., Stark, Y., Plückthun, A. & Hine, A. V., 17 Jul 2019.

Research output: Contribution to conferencePoster

Saturation mutagenesis and precision libraries: the numbers game

Hine, A. V., Chembath, A., Ferreira Amaral, M., Wagstaffe, B., Stark, Y. & Plückthun, A., 2019.

Research output: Contribution to conferenceAbstract

open access

Aminoacyl-tRNA Synthetases: Investigations of Specificity for Application in ProxiMAX / Synthetic Biology.

Ferreira Amaral, M., Frigotto, L., Ullman, C. G., Hermans, G. & Hine, A. V., 23 Sep 2018, (Unpublished).

Research output: Contribution to conferenceAbstract

Synthetic Biology
Amino Acyl-tRNA Synthetases
Amino Acids
Random Allocation


A technique to randomise consecutive codons in a sequence of DNA using MAX oligonucleotides

Author: Ashraf, M., 2006

Supervisor: Sutherland, A. V. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy


CNK1 scaffold protein and its role in the regulations of NF-KB signalling

Author: Pansare, K., 2013

Supervisor: Pitt, A. R. (Supervisor) & Sutherland, A. V. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

Development of the MAX randomisation technique

Author: Nagel, D. A., Sep 2003

Supervisor: Sutherland, A. V. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy


Discovering properties of new DNA-binding activity of proteins

Author: Wang, X., 18 Jun 2014

Supervisor: Lowe, D. (Supervisor) & Sutherland, A. V. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy


Mechanism of protein catobolism in skeletal muscle during cancer cachexia

Author: Khal, J., 2002

Supervisor: Tisdale, M. J. (Supervisor) & Sutherland, A. V. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy


Activities 2006 2016

BBSRC Follow-on-Fund Committee (External organisation)

Anna V. Hine (Member)
Mar 2016Feb 2020

Activity: Membership typesMembership of council

Consultant, Isogenica Ltd.

Anna V. Hine (Advisor)

Activity: Consultancy typesConsultancy

International Advisory Board, Thermo Fisher

Anna V. Hine (Advisor)
May 2010

Activity: Consultancy typesConsultancy

Training placement, funded by the regional council of Languedoc-Roussillon (France).

Anna V. Hine (Host)
Apr 2010Jul 2010

Activity: Other activity typesTypes of External academic engagement - Hosting an academic visitor

Consultant, Intrexon Inc.

Anna V. Hine (Advisor)

Activity: Consultancy typesConsultancy