Analysis of radicals and radical reaction products in cell signalling and biomolecular damage: the long hard road to gold-standard measures

Paul G Winyard, Corinne M Spickett, Helen R Griffiths

Research output: Contribution to journalArticle

Abstract

The field of free radical biology and medicine continues to move at a tremendous pace, with a constant flow of ground-breaking discoveries. The following collection of papers in this issue of Biochemical Society Transactions highlights several key areas of topical interest, including the crucial role of validated measurements of radicals and reactive oxygen species in underpinning nearly all research in the field, the important advances being made as a result of the overlap of free radical research with the reinvigorated field of lipidomics (driven in part by innovations in MS-based analysis), the acceleration of new insights into the role of oxidative protein modifications (particularly to cysteine residues) in modulating cell signalling, and the effects of free radicals on the functions of mitochondria, extracellular matrix and the immune system. In the present article, we provide a brief overview of these research areas, but, throughout this discussion, it must be remembered that it is the availability of reliable analytical methodologies that will be a key factor in facilitating continuing developments in this exciting research area.
LanguageEnglish
Pages1217-1220
Number of pages4
JournalBiochemical Society Transactions
Volume39
Issue number5
DOIs
Publication statusPublished - Oct 2011

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Cell signaling
Reaction products
Gold
Free Radicals
Research
Mitochondria
Immune system
Medicine
Extracellular Matrix
Cysteine
Immune System
Reactive Oxygen Species
Innovation
Availability
Proteins

Keywords

  • Free Radicals
  • Humans
  • Oxidation-Reduction
  • Oxidative Stress
  • Reactive Oxygen Species
  • Signal Transduction

Cite this

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Analysis of radicals and radical reaction products in cell signalling and biomolecular damage : the long hard road to gold-standard measures. / Winyard, Paul G; Spickett, Corinne M; Griffiths, Helen R.

In: Biochemical Society Transactions, Vol. 39, No. 5, 10.2011, p. 1217-1220.

Research output: Contribution to journalArticle

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