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Personal profile

General

I joined the School of Life and Health Sciences in January 2011, after 17 years as an academic member of staff at the University of Strathclyde. I worked in several different departments there, starting in Chemistry, then moving to Immunology, Bioscience, and lastly Strathclyde Institute of Pharmacy and Biomedical Science. This reflects my broad scientific background and interests in oxidative stress ranging from molecular processes to inflammation in disease.

I have extensive collaborations in Europe: currently I am treasurer of the Society for Free Radical Research (Europe), a workgroup leader in the COST Action CM1001 on “Chemistry of non-enzymatic protein modification”, and a member of the International HNE-Club committee, having just stood down as secretary.

I have taught extensively in biological and biomedical related classes at the University of Strathclyde, where my primary focus was on biochemistry, metabolism and molecular events in cardiovascular disease. I have also been an invited lecturer for the Masters in Integrative Physiology at the University of Barcelona, and have lectured at the Spetses Free Radical Summer School run by the Society of Free Radical Research Europe.

Research Interests

My research is centred in the field of Redox Biology and Oxidative Stress, and I am an internationally recognized researcher in this field. Redox balance controls many cell signaling pathways leading to cell proliferation, differentiation and toxicity. I am particularly well-known for research on analysis of oxidized phospholipids using mass spectrometry, and recently this has expanded into lipidomics and ox-lipidomics. My group also works on analysis and biological effects of protein oxidation both in vitro and in vivo. A strong current focus is on the structure-function relationship of protein lipoxidation, which involves the formation of adducts of oxidative lipids with proteins, which is important in many inflammatory diseases and cancer.

I currently lead the Horizon 2020 Innovative training network MASSTRPLAN (Mass Spectrometry Training network in Protein Lipid Adduct Analysis), which has been running since 2015. More information is available on our webpage https://www.masstrplan.org/. I am also a member of AMPL (Aston Membrane Proteins and Lipids group) and a Co-investigator on the international collaborative projects MemBrane and MemTrain.

Teaching Activity

I am currently module leader for a 2nd year module called Molecular Pathology (BY2PA2), and in 2019-20 will be module leader for the new Analytical Biochemistry module. I also teach in Metabolism (BY2BC1 and BC1006), Biological Basis of Disease (BY3BD2 and BI4005), and 1st and 2nd Year Key Skills. I am a tutor for placement students and usually accept 2 in my lab each year, as well as taking final year project students.

Qualifications

  • BA (Hons) Biochemistry  - Oxford University (Pembroke College) - 1986
  • DPhil Biochemistry - Oxford University (Pembroke College) - 1990
  • MA  - Oxford University (Pembroke College) - 1990  

Employment

  • August 2006 - January 2011: Senior Lecturer, SIPBS, University of Strathclyde.
  • April 2005 - August 2006: Senior Lecturer, Department of Bioscience, University of Strathclyde.
  • September 2001 – April 2005: Lecturer, Department of Bioscience, University of Strathclyde.
  • September 1994 - August 2001: Glaxo-Jack Research Lecturer, Department of Immunology, University of Strathclyde.
  • April 1993 - to August 1994:  SHHD funded postdoctoral research fellow in the Dept. of Pure and Applied Chemistry, Strathclyde, working with Prof. W.E. Smith. (An investigation of oxidative stress in preeclamptic erythrocytes using in vivo NMR and resonance Raman spectroscopy).
  • April 1992 - March 1993:  AFRC funded postdoctoral research assistant to Dr C. Abell, Department of Chemistry, Cambridge. (The purification of kaurene synthase and related diterpene cyclases from Ricinus communis).
  • October 1989 - March 1992:  AFRC funded postdoctoral research assistant to Dr B.C. Loughman and Dr R.G. Ratcliffe, Department of Plant Sciences, Oxford. (The application of in vivo NMR to the study of plant systems).

Membership of Professional Bodies

  • The Biochemical Society (1986-present)
  • Society for Free Radical Research (1995-present)
  • Society for General Microbiology (1997-present)
  • British Society for Cardiovascular Research (2003-present)

PhD Supervision

I have supervised more than 20 graduate research students and about 20 visiting scientists from a variety of countries.  PhD students graduated at Aston University are shown on the "Student Theses" Page. Currently I am primary or associate supervisor for 6 PhD students, 3 of whom are finishing this year.

Contact Details

Tel: +44 (0)121 204 4085
Email: c.m.spickett@aston.ac.uk
Room number: MB 357F

Keywords

  • QP Physiology
  • Biochemistry
  • Redox Biology
  • Oxidative Stress
  • ox-lipidomics
  • proteomics

Fingerprint Dive into the research topics where Corinne Spickett is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 4 Similar Profiles
Phospholipids Medicine & Life Sciences
Mass spectrometry Chemical Compounds
Lipids Medicine & Life Sciences
Oxidation Chemical Compounds
Mass Spectrometry Medicine & Life Sciences
Chlorohydrins Medicine & Life Sciences
Proteins Chemical Compounds
Oxidation-Reduction Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1994 2019

Analysis of SMALP co-extracted phospholipids shows distinct membrane environments for three classes of bacterial membrane protein

Teo, A. C. K., Lee, S. C., Pollock, N. L., Stroud, Z., Hall, S., Thakker, A., Pitt, A. R., Dafforn, T. R., Spickett, C. M. & Roper, D. I., 12 Feb 2019, In : Scientific Reports. 9, 1, 1813.

Research output: Contribution to journalArticle

Open Access
File
Bacterial Proteins
Phospholipids
Membrane Proteins
Lipids
Styrene

Epitope mapping and characterization of 4-hydroxy-2-nonenal modified-human serum albumin using two different polyclonal antibodies

Campos-pinto, I., Méndez, L., Schouten, J., Wilkins, J., Fedorova, M., Pitt, A., Davis, P. & Spickett, C., 7 May 2019, In : Free Radical Biology and Medicine. 144, p. 234-244 11 p.

Research output: Contribution to journalArticle

Open Access
File
Epitope Mapping
Serum Albumin
Epitopes
Antibodies
Peptides

Evaluation of air oxidized PAPC: A multi laboratory study by LC-MS/MS

Ni, Z., Sousa, B. C., Colombo, S., Afonso, C. B., Melo, T., Pitt, A. R., Spickett, C. M., Domingues, P., Domingues, M. R., Fedorova, M. & Criscuolo, A., 15 Jun 2019, In : Free Radical Biology and Medicine. 144, p. 156-166 11 p.

Research output: Contribution to journalArticle

Open Access
File
Air
Lipids
Lipid Peroxidation
Oxidation
Arachidonic Acids

Increased production of 27-hydroxycholesterol in human colorectal cancer advanced stage: Possible contribution to cancer cell survival and infiltration

Rossin, D., Dias, I. H. K., Solej, M., Milic, I., Pitt, A. R., Iaia, N., Scoppapietra, L., Devitt, A., Nano, M., Degiuli, M., Volante, M., Caccia, C., Leoni, V., Griffiths, H. R., Spickett, C. M., Poli, G. & Biasi, F., 20 May 2019, In : Free Radical Biology and Medicine. 136, p. 35-44 10 p.

Research output: Contribution to journalArticle

Infiltration
Colorectal Neoplasms
Cell Survival
Cells
Tumors

PARP1 Co-regulates EP300–BRG1-dependent transcription of genes involved in breast cancer cell proliferation and DNA repair

Sobczak, M., Pitt, A. R., Spickett, C. M. & Robaszkiewicz, A., 11 Oct 2019, In : Cancers. 11, 10, 1539.

Research output: Contribution to journalArticle

Open Access
File
DNA Repair
Cell Proliferation
Breast Neoplasms
Genes
Adenosine Diphosphate

Thesis

Biotechnology for detecting oxidative modifications to fibrinogen

Author: Meredith, S., 2016

Supervisor: Spickett, C. M. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File

Technologies to study protein oxidation in ageing Investigating the effect of protein oxidation on protein function

Author: Calimport, S., 2 Mar 2017

Supervisor: Pitt, A. R. (Supervisor) & Spickett, C. M. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File

The role of protein oxidation in ageing & disease

Author: Pasha, S., 2016

Supervisor: Pitt, A. R. (Supervisor) & Spickett, C. M. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File

Activities 2004 2015

Free Radical Research (Journal)

Corinne Spickett (Editorial board member)
20152021

Activity: Publication peer-review and editorial work typesEditorial activity

Oxygen Club of California World Congress

Corinne Spickett (Invited speaker)
20 Jun 201223 Jun 2012

Activity: Participating in or organising an event typesParticipation in conference

International Symposium on Redox Signaling and Oxidative Stress in Health and Disease

Corinne Spickett (Invited speaker)
5 Jun 20127 Jun 2012

Activity: Participating in or organising an event typesParticipation in conference

Proteomics Workshop 2012

Corinne Spickett (Invited speaker)
4 Jun 20126 Jun 2012

Activity: Participating in or organising an event typesParticipation in conference

Erasmus Practicum from University of Barcelona. Research will involve analysis of oxidative damage to biomolecules using cultured cells as models.

Corinne Spickett (Host)
2012 → …

Activity: Other activity typesTypes of External academic engagement - Hosting an academic visitor