OBJECTIVES: Persistent contamination of surfaces by spores of Clostridium difficile is a major factor influencing the spread of C. difficile-associated diarrhoea (CDAD) in the clinical setting. In recent years, the antimicrobial efficacy of metal surfaces has been investigated against microorganisms including methicillin-resistant Staphylococcus aureus. This study compared the survival of C. difficile on stainless steel, a metal contact surface widely used in hospitals, and copper surfaces. METHODS: Antimicrobial efficacy was assessed using a carrier test method against dormant spores, germinating spores and vegetative cells of C. difficile (NCTC 11204 and ribotype 027) over a 3 h period in the presence and absence of organic matter. RESULTS: Copper metal eliminated all vegetative cells of C. difficile within 30 min, compared with stainless steel which demonstrated no antimicrobial activity (P < 0.05). Copper significantly reduced the viability of spores of C. difficile exposed to the germinant (sodium taurocholate) in aerobic conditions within 60 min (P < 0.05) while achieving a >or=2.5 log reduction (99.8% reduction) at 3 h. Organic material did not reduce the antimicrobial efficacy of the copper surface (P > 0.05).
Bibliographical note18th European Congress of Clinical Microbiology and Infectious Diseases, Barcelona (ES), 19-22 April 2008.
- nosocomial infection
Wheeldon, L. J., Worthington, T., Lambert, P. A., Hilton, A., Lowden, C. J., & Elliott, T. S. J. (2008). Antimicrobial efficacy of copper surfaces against spores and vegetative cells of Clostridium difficile: the germination theory. Journal of Antimicrobial Chemotherapy, 62(3), 522-525. https://doi.org/10.1093/jac/dkn219