Apoptotic cell-derived extracellular vesicles: structure-function relationships.

Lois Grant; Ivana Milic; Andrew Devitt

doi:10.1042/BST20180080

Apoptotic cell-derived extracellular vesicles: structure-function relationships.

Research output: Contribution to journal › Review article › peer-review

Abstract

Apoptosis is an essential process for normal physiology and plays a key role in the resolution of inflammation. Clearance of apoptotic cells (ACs) involves complex signalling between phagocytic cells, ACs, and the extracellular vesicles (EVs) they produce. Here, we discuss apoptotic cell-derived extracellular vesicles (ACdEVs) and how their structure relates to their function in AC clearance and the control of inflammation, focussing on the ACdEV proteome. We review the current knowledge, ongoing work and future directions for research in this field.

Original language	English
Pages (from-to)	509-516
Number of pages	8
Journal	Biochemical Society Transactions
Volume	47
Issue number	2
Early online date	5 Apr 2019
DOIs	https://doi.org/10.1042/BST20180080
Publication status	Published - 30 Apr 2019

Bibliographical note

Keywords

extracellular vesicles
macrophages
phagocytosis

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10.1042/BST20180080

Apoptotic Cell-derived Extracellular Vesicles: Structure-Function Relationships
© 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society
Accepted author manuscript, 483 KB

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title = "Apoptotic cell-derived extracellular vesicles: structure-function relationships.",

abstract = "Apoptosis is an essential process for normal physiology and plays a key role in the resolution of inflammation. Clearance of apoptotic cells (ACs) involves complex signalling between phagocytic cells, ACs, and the extracellular vesicles (EVs) they produce. Here, we discuss apoptotic cell-derived extracellular vesicles (ACdEVs) and how their structure relates to their function in AC clearance and the control of inflammation, focussing on the ACdEV proteome. We review the current knowledge, ongoing work and future directions for research in this field.",

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T1 - Apoptotic cell-derived extracellular vesicles: structure-function relationships.

AU - Grant, Lois

AU - Milic, Ivana

AU - Devitt, Andrew

PY - 2019/4/30

Y1 - 2019/4/30

N2 - Apoptosis is an essential process for normal physiology and plays a key role in the resolution of inflammation. Clearance of apoptotic cells (ACs) involves complex signalling between phagocytic cells, ACs, and the extracellular vesicles (EVs) they produce. Here, we discuss apoptotic cell-derived extracellular vesicles (ACdEVs) and how their structure relates to their function in AC clearance and the control of inflammation, focussing on the ACdEV proteome. We review the current knowledge, ongoing work and future directions for research in this field.

AB - Apoptosis is an essential process for normal physiology and plays a key role in the resolution of inflammation. Clearance of apoptotic cells (ACs) involves complex signalling between phagocytic cells, ACs, and the extracellular vesicles (EVs) they produce. Here, we discuss apoptotic cell-derived extracellular vesicles (ACdEVs) and how their structure relates to their function in AC clearance and the control of inflammation, focussing on the ACdEV proteome. We review the current knowledge, ongoing work and future directions for research in this field.

KW - extracellular vesicles

KW - macrophages

KW - phagocytosis

UR - http://www.biochemsoctrans.org/content/early/2019/04/03/BST20180080.full-text.pdf

UR - http://www.scopus.com/inward/record.url?scp=85065509331&partnerID=8YFLogxK

U2 - 10.1042/BST20180080

DO - 10.1042/BST20180080

M3 - Review article

SN - 0300-5127

VL - 47

SP - 509

EP - 516

JO - Biochemical Society Transactions

JF - Biochemical Society Transactions

IS - 2

ER -

Apoptotic cell-derived extracellular vesicles: structure-function relationships.

Abstract

Bibliographical note

Keywords

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