Apoptotic cell-derived extracellular vesicles: structure-function relationships.

Research output: Contribution to journalReview article

Abstract

Apoptosis is an essential process for normal physiology and plays a key role in the resolution of inflammation. Clearance of apoptotic cells (ACs) involves complex signalling between phagocytic cells, ACs, and the extracellular vesicles (EVs) they produce. Here, we discuss apoptotic cell-derived extracellular vesicles (ACdEVs) and how their structure relates to their function in AC clearance and the control of inflammation, focussing on the ACdEV proteome. We review the current knowledge, ongoing work and future directions for research in this field.
Original languageEnglish
Pages (from-to)509-516
Number of pages8
JournalBiochemical Society Transactions
Volume47
Issue number2
Early online date5 Apr 2019
DOIs
Publication statusPublished - 30 Apr 2019

Fingerprint

Cells
Physiology
Proteome
Apoptosis
Inflammation
Phagocytes
Extracellular Vesicles
Research
Direction compound

Bibliographical note

© 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society

Keywords

  • extracellular vesicles
  • macrophages
  • phagocytosis

Cite this

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Apoptotic cell-derived extracellular vesicles: structure-function relationships. / Grant, Lois; Milic, Ivana; Devitt, Andrew.

In: Biochemical Society Transactions, Vol. 47, No. 2, 30.04.2019, p. 509-516.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Apoptotic cell-derived extracellular vesicles: structure-function relationships.

AU - Grant, Lois

AU - Milic, Ivana

AU - Devitt, Andrew

N1 - © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society

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AB - Apoptosis is an essential process for normal physiology and plays a key role in the resolution of inflammation. Clearance of apoptotic cells (ACs) involves complex signalling between phagocytic cells, ACs, and the extracellular vesicles (EVs) they produce. Here, we discuss apoptotic cell-derived extracellular vesicles (ACdEVs) and how their structure relates to their function in AC clearance and the control of inflammation, focussing on the ACdEV proteome. We review the current knowledge, ongoing work and future directions for research in this field.

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KW - macrophages

KW - phagocytosis

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