Calcitonin gene-related peptide (CGRP) and adrenomedullin are related peptides, which are potent vasodilators. The CGRP and adrenomedullin receptors are unusual receptors, comprising a G-protein-coupled receptor (GPCR) with receptor activity-modifying proteins (RAMPs). The GPCR, the calcitonin receptor-like receptor (CLR), forms a CGRP receptor with RAMP1, whereas CLR with RAMP2 or RAMP3 forms two subtypes of adrenomedullin receptor. This article covers the pharmacology of these receptors, their distribution, and potential involvement in disease.
|Title of host publication||Encyclopedia of Biological Chemistry|
|Subtitle of host publication||Second Edition|
|Number of pages||5|
|Publication status||Published - 15 Feb 2013|
- Calcitonin gene-related peptide
- G-protein-coupled receptor
- Receptor activity-modifying protein