Calcitonin Gene-Related Peptide and Adrenomedullin Receptors

D. L. Hay, A. C. Conner, D. R. Poyner

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Calcitonin gene-related peptide (CGRP) and adrenomedullin are related peptides, which are potent vasodilators. The CGRP and adrenomedullin receptors are unusual receptors, comprising a G-protein-coupled receptor (GPCR) with receptor activity-modifying proteins (RAMPs). The GPCR, the calcitonin receptor-like receptor (CLR), forms a CGRP receptor with RAMP1, whereas CLR with RAMP2 or RAMP3 forms two subtypes of adrenomedullin receptor. This article covers the pharmacology of these receptors, their distribution, and potential involvement in disease.

LanguageEnglish
Title of host publicationEncyclopedia of Biological Chemistry
Subtitle of host publicationSecond Edition
PublisherElsevier
Pages265-269
Number of pages5
ISBN (Electronic)9780123786319
ISBN (Print)9780123786302
DOIs
Publication statusPublished - 15 Feb 2013

Fingerprint

Calcitonin Receptor-Like Protein
Adrenomedullin Receptors
Calcitonin Gene-Related Peptide Receptors
G-Protein-Coupled Receptors
Receptor Activity-Modifying Proteins
Adrenomedullin
Calcitonin Gene-Related Peptide
Vasodilator Agents
Pharmacology
Peptides

Keywords

  • Adrenomedullin
  • Calcitonin gene-related peptide
  • G-protein-coupled receptor
  • Receptor activity-modifying protein

Cite this

Hay, D. L., Conner, A. C., & Poyner, D. R. (2013). Calcitonin Gene-Related Peptide and Adrenomedullin Receptors. In Encyclopedia of Biological Chemistry: Second Edition (pp. 265-269). Elsevier. https://doi.org/10.1016/B978-0-12-378630-2.00363-7
Hay, D. L. ; Conner, A. C. ; Poyner, D. R. / Calcitonin Gene-Related Peptide and Adrenomedullin Receptors. Encyclopedia of Biological Chemistry: Second Edition. Elsevier, 2013. pp. 265-269
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Hay, DL, Conner, AC & Poyner, DR 2013, Calcitonin Gene-Related Peptide and Adrenomedullin Receptors. in Encyclopedia of Biological Chemistry: Second Edition. Elsevier, pp. 265-269. https://doi.org/10.1016/B978-0-12-378630-2.00363-7

Calcitonin Gene-Related Peptide and Adrenomedullin Receptors. / Hay, D. L.; Conner, A. C.; Poyner, D. R.

Encyclopedia of Biological Chemistry: Second Edition. Elsevier, 2013. p. 265-269.

Research output: Chapter in Book/Report/Conference proceedingChapter

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Hay DL, Conner AC, Poyner DR. Calcitonin Gene-Related Peptide and Adrenomedullin Receptors. In Encyclopedia of Biological Chemistry: Second Edition. Elsevier. 2013. p. 265-269 https://doi.org/10.1016/B978-0-12-378630-2.00363-7