Calcitonin Gene-Related Peptide and Adrenomedullin Receptors

D. L. Hay; A. C. Conner; D. R. Poyner

doi:10.1016/B978-0-12-378630-2.00363-7

Calcitonin Gene-Related Peptide and Adrenomedullin Receptors

D. L. Hay^*, A. C. Conner, D. R. Poyner

^*Corresponding author for this work

Research output: Chapter in Book/Published conference output › Chapter

Abstract

Calcitonin gene-related peptide (CGRP) and adrenomedullin are related peptides, which are potent vasodilators. The CGRP and adrenomedullin receptors are unusual receptors, comprising a G-protein-coupled receptor (GPCR) with receptor activity-modifying proteins (RAMPs). The GPCR, the calcitonin receptor-like receptor (CLR), forms a CGRP receptor with RAMP1, whereas CLR with RAMP2 or RAMP3 forms two subtypes of adrenomedullin receptor. This article covers the pharmacology of these receptors, their distribution, and potential involvement in disease.

Original language	English
Title of host publication	Encyclopedia of Biological Chemistry
Subtitle of host publication	Second Edition
Publisher	Elsevier
Pages	265-269
Number of pages	5
ISBN (Electronic)	9780123786319
ISBN (Print)	9780123786302
DOIs	https://doi.org/10.1016/B978-0-12-378630-2.00363-7
Publication status	Published - 15 Feb 2013

Keywords

Adrenomedullin
Calcitonin gene-related peptide
G-protein-coupled receptor
Receptor activity-modifying protein

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10.1016/B978-0-12-378630-2.00363-7

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title = "Calcitonin Gene-Related Peptide and Adrenomedullin Receptors",

abstract = "Calcitonin gene-related peptide (CGRP) and adrenomedullin are related peptides, which are potent vasodilators. The CGRP and adrenomedullin receptors are unusual receptors, comprising a G-protein-coupled receptor (GPCR) with receptor activity-modifying proteins (RAMPs). The GPCR, the calcitonin receptor-like receptor (CLR), forms a CGRP receptor with RAMP1, whereas CLR with RAMP2 or RAMP3 forms two subtypes of adrenomedullin receptor. This article covers the pharmacology of these receptors, their distribution, and potential involvement in disease.",

keywords = "Adrenomedullin, Calcitonin gene-related peptide, G-protein-coupled receptor, Receptor activity-modifying protein",

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T1 - Calcitonin Gene-Related Peptide and Adrenomedullin Receptors

AU - Hay, D. L.

AU - Conner, A. C.

AU - Poyner, D. R.

PY - 2013/2/15

Y1 - 2013/2/15

N2 - Calcitonin gene-related peptide (CGRP) and adrenomedullin are related peptides, which are potent vasodilators. The CGRP and adrenomedullin receptors are unusual receptors, comprising a G-protein-coupled receptor (GPCR) with receptor activity-modifying proteins (RAMPs). The GPCR, the calcitonin receptor-like receptor (CLR), forms a CGRP receptor with RAMP1, whereas CLR with RAMP2 or RAMP3 forms two subtypes of adrenomedullin receptor. This article covers the pharmacology of these receptors, their distribution, and potential involvement in disease.

AB - Calcitonin gene-related peptide (CGRP) and adrenomedullin are related peptides, which are potent vasodilators. The CGRP and adrenomedullin receptors are unusual receptors, comprising a G-protein-coupled receptor (GPCR) with receptor activity-modifying proteins (RAMPs). The GPCR, the calcitonin receptor-like receptor (CLR), forms a CGRP receptor with RAMP1, whereas CLR with RAMP2 or RAMP3 forms two subtypes of adrenomedullin receptor. This article covers the pharmacology of these receptors, their distribution, and potential involvement in disease.

KW - Adrenomedullin

KW - Calcitonin gene-related peptide

KW - G-protein-coupled receptor

KW - Receptor activity-modifying protein

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UR - https://www.sciencedirect.com/science/article/pii/B9780123786302003637

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DO - 10.1016/B978-0-12-378630-2.00363-7

M3 - Chapter

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SN - 9780123786302

SP - 265

EP - 269

BT - Encyclopedia of Biological Chemistry

PB - Elsevier

ER -

Calcitonin Gene-Related Peptide and Adrenomedullin Receptors

Abstract

Keywords

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