In vivo analysis of ciliary muscle morphologic changes with accommodation and axial ametropia

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Abstract

Purpose. To use anterior segment optical coherence tomography (AS-OCT) to analyze ciliary muscle morphology and changes with accommodation and axial ametropia.
Methods. Fifty prepresbyopic volunteers, aged 19 to 34 years were recruited. High-resolution images were acquired of nasal and temporal ciliary muscles in the relaxed state and at stimulus vergence levels of -4 and -8 D. Objective accommodative responses and axial lengths were also recorded. Two-way, mixed-factor analyses of variance (ANOVAs) were used to assess the changes in ciliary muscle parameters with accommodation and determine whether these changes are dependent on the nasal–temporal aspect or axial length, whereas linear regression analysis was used to analyze the relationship between axial length and ciliary muscle length.
Results. The ciliary muscle was longer (r = 0.34, P = 0.02), but not significantly thicker (F = 2.84, P = 0.06), in eyes with greater axial length. With accommodation, the ciliary muscle showed a contractile shortening (F = 42.9. P < 0.001), particularly anteriorly (F = 177.2, P < 0.001), and a thickening of the anterior portion (F= 46.2, P < 0.001). The ciliary muscle was thicker (F = 17.8, P < 0.001) and showed a greater contractile response on the temporal side.
Conclusions. The accommodative changes observed support an anterior, as well as centripetal, contractile shift of ciliary muscle mass.
Original languageEnglish
Pages (from-to)6882-6889
Number of pages8
JournalInvestigative Ophthalmology and Visual Science
Volume51
Issue number12
Early online date29 Jul 2010
DOIs
Publication statusPublished - Dec 2010

Bibliographical note

Creative Commons Attribution Non-Commercial No Derivatives License

Keywords

  • ocular accommodation
  • adult
  • biometry
  • ciliary body
  • ophthalmological diagnostic techniques
  • humans
  • smooth muscle
  • pilot projects
  • refractive errors
  • reproducibility of results
  • optical coherence tomography
  • young adults

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