Abstract
N-Heterocyclic cations are incorporated into proteins using 5-(2-bromoethyl)phenanthridinium bromide, which selectively reacts with either cysteine or lysine residues, resulting in ethylphenanthridinium (Phen) or highly stable cyclised dihydro-imidazo-phenanthridinium (DIP) adducts respectively; these modifications have been found to manipulate the observed structure of lysozyme and bovine serum albumin by AFM.
Original language | English |
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Pages (from-to) | 2581-3258 |
Number of pages | 3 |
Journal | Chemical Communications |
Volume | 2007 |
Issue number | 25 |
DOIs | |
Publication status | Published - May 2007 |
Keywords
- animals
- cell membrane
- chickens
- egg white
- fluorescein-5-isothiocyanate
- heterocyclic compounds
- atomic force microscopy
- muramidase
- proteins
- bovine serum albumin