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Personal profile

Research Interests

My research has always been about understanding how biology works at the molecular level, using a multidisciplinary approach combining chemistry, biology, physics and engineering. We are developing techniques and technologies and applying them to help to understand complex biological problems, but to be effective this has to be done collaboration with many other talented research groups.  Many of the techniques and technologies we are developing also have a much broader applications, and we have research in many areas including drug discovery and analysis, chemical biology, biomarker discovery, biotechnology, biocatalysis, and systems and synthetic biology. One of our aims is to generate a better understanding, diagnosis, stratification, and treatment of disease, from identifying new targets for drugs, through to monitoring the therapeutic effect of drugs in the clinic.
At the cellular level we are interested in how the complex pathways involved in intracellular signalling are regulated, the role of redox chemistry in signalling and cellular damage, and understanding the molecular targets of drugs.

To see how I got into this and some of the research that I have been involved in along the way, you can watch my Inaugural Lecture on YouTube.

 

I am professor of Pharmaceutical Chemistry and Chemical Biology, but what are these?

  • Pharmaceutical chemistry is the process of making a new drugs, including their design, synthesis, and optimization of the drug molecules.
  • Chemical biology is the application of chemistry, including the use of chemical compounds and chemical tools and technologies, to study and manipulate biology.

Teaching Activity

MPharm Programme

PH3602: Antimicrobial agents and anticancer agents
PH3605: Medicinal chemistry – drugs from natural products and modern approaches to target discovery

Pharmacy Postgraduate Programme

PHM009: Antimicrobial agents and anticancer agents

Membership of Professional Bodies

  • Fellow of the Royal Society of Chemistry

  • Fellow of the Royal Society of Biology

  • Council member of the Chemistry Biology Interface Division of the Royal Society of Chemistry
  • Treasurer and past President of the British Society for Proteome Research (BSPR)

  • Member of the Executive Council of the European Proteomics Association and Chair of the Journals committee

  • Member of The Biochemical Society

Qualifications

BSc Chemistry (1st Class Honours), University of Bristol

DPhil Bioorganic Chemistry, University of Oxford

Employment

2019 -                 Assocoate Head of Pharmacy (Research), Aston University

2017-2018           Associate Dean for Research, Life and Health Sciences, Aston University

2012 -                 Professor of Pharmaceutical Chemistry and Chemical Biology, Aston University

2009 - 2011         Reader, Division of Integrative and Systems Biology, Institute of Biomedical and Life Sciences                              

2005 - 2011         Director, RASOR Interdisciplinary Research Collaboration in Proteomic Technologies                            
2005 - 2011         Director, Doctoral Training Centre in Proteomics

2005 - 2011         Director, Sir Henry Wellcome Functional Genomics Facility

2005 - 2009         Senior Lecturer in Proteomics, Division of Integrative and Systems Biology, Institute of Biomedical and Life Sciences                            

2002 - 2005         Deputy Director and Head of Proteomics, SHWFGF, University of Glasgow

1993 - 2002         Lecturer, Department of Pure and Applied Chemistry, University of Strathclyde.

1990 - 1993         Research Fellow, St. Catharine's College, Cambridge.

1989 - 1992         Schering Fellow in Bioorganic Chemistry, Department of Chemistry, University of Cambridge  

1988 - 1989         Research Assistant, Oxford University.

 

Contact Details

Email: a.r.pitt@aston.ac.uk 
Tel:
 +44 (0)121 204 3005

Fingerprint Dive into the research topics where Andrew Pitt is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 5 Similar Profiles
Mass spectrometry Chemical Compounds
Mass Spectrometry Medicine & Life Sciences
Phospholipids Medicine & Life Sciences
Proteins Chemical Compounds
Oxidation Chemical Compounds
Lipids Chemical Compounds
Chlorohydrins Medicine & Life Sciences
Ions Chemical Compounds

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1998 2019

Analysis of SMALP co-extracted phospholipids shows distinct membrane environments for three classes of bacterial membrane protein

Teo, A. C. K., Lee, S. C., Pollock, N. L., Stroud, Z., Hall, S., Thakker, A., Pitt, A. R., Dafforn, T. R., Spickett, C. M. & Roper, D. I., 12 Feb 2019, In : Scientific Reports. 9, 1, 1813.

Research output: Contribution to journalArticle

Open Access
File
Bacterial Proteins
Phospholipids
Membrane Proteins
Lipids
Styrene

Epitope mapping and characterization of 4-hydroxy-2-nonenal modified-human serum albumin using two different polyclonal antibodies

Campos-pinto, I., Méndez, L., Schouten, J., Wilkins, J., Fedorova, M., Pitt, A., Davis, P. & Spickett, C., 7 May 2019, In : Free Radical Biology and Medicine. 144, p. 234-244 11 p.

Research output: Contribution to journalArticle

Open Access
File
Epitope Mapping
Serum Albumin
Epitopes
Antibodies
Peptides

Evaluation of air oxidized PAPC: A multi laboratory study by LC-MS/MS

Ni, Z., Sousa, B. C., Colombo, S., Afonso, C. B., Melo, T., Pitt, A. R., Spickett, C. M., Domingues, P., Domingues, M. R., Fedorova, M. & Criscuolo, A., 15 Jun 2019, In : Free Radical Biology and Medicine. 144, p. 156-166 11 p.

Research output: Contribution to journalArticle

Open Access
File
Air
Lipids
Lipid Peroxidation
Oxidation
Arachidonic Acids

Increased production of 27-hydroxycholesterol in human colorectal cancer advanced stage: Possible contribution to cancer cell survival and infiltration

Rossin, D., Dias, I. H. K., Solej, M., Milic, I., Pitt, A. R., Iaia, N., Scoppapietra, L., Devitt, A., Nano, M., Degiuli, M., Volante, M., Caccia, C., Leoni, V., Griffiths, H. R., Spickett, C. M., Poli, G. & Biasi, F., 20 May 2019, In : Free Radical Biology and Medicine. 136, p. 35-44 10 p.

Research output: Contribution to journalArticle

Infiltration
Colorectal Neoplasms
Cell Survival
Cells
Tumors

PARP1 Co-regulates EP300–BRG1-dependent transcription of genes involved in breast cancer cell proliferation and DNA repair

Sobczak, M., Pitt, A. R., Spickett, C. M. & Robaszkiewicz, A., 11 Oct 2019, In : Cancers. 11, 10, 1539.

Research output: Contribution to journalArticle

Open Access
File
DNA Repair
Cell Proliferation
Breast Neoplasms
Genes
Adenosine Diphosphate

Thesis

CNK1 scaffold protein and its role in the regulations of NF-KB signalling

Author: Pansare, K., 2013

Supervisor: Pitt, A. R. (Supervisor) & Sutherland, A. V. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

Technologies to study protein oxidation in ageing Investigating the effect of protein oxidation on protein function

Author: Calimport, S., 2 Mar 2017

Supervisor: Pitt, A. R. (Supervisor) & Spickett, C. M. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File

The role of protein oxidation in ageing & disease

Author: Pasha, S., 2016

Supervisor: Pitt, A. R. (Supervisor) & Spickett, C. M. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File