Innovative biomarkers for predicting type 2 diabetes mellitus

relevance to dietary management of frailty in older adults

John Ikwuobe, Srikanth Bellary, Helen R. Griffiths

Research output: Contribution to journalArticle

Abstract

Type 2 diabetes mellitus (T2DM) increases in prevalence in the elderly. There is evidence for significant muscle loss and accelerated cognitive impairment in older adults with T2DM; these comorbidities are critical features of frailty. In the early stages of T2DM, insulin sensitivity can be improved by a “healthy” diet. Management of insulin resistance by diet in people over 65 years of age should be carefully re-evaluated because of the risk for falling due to hypoglycaemia. To date, an optimal dietary programme for older adults with insulin resistance and T2DM has not been described. The use of biomarkers to identify those at risk for T2DM will enable clinicians to offer early dietary advice that will delay onset of disease and of frailty. Here we have used an in silico literature search for putative novel biomarkers of T2DM risk and frailty. We suggest that plasma bilirubin, plasma, urinary DPP4-positive microparticles and plasma pigment epithelium-derived factor merit further investigation as predictive biomarkers for T2DM and frailty risk in older adults. Bilirubin is screened routinely in clinical practice. Measurement of specific microparticle frequency in urine is less invasive than a blood sample so is a good choice for biomonitoring. Future studies should investigate whether early dietary changes, such as increased intake of whey protein and micronutrients that improve muscle function and insulin sensitivity, affect biomarkers and can reduce the longer term complication of frailty in people at risk for T2DM.

Original languageEnglish
Pages (from-to)511–527
Number of pages17
JournalBiogerontology
Volume17
Issue number3
Early online date20 Feb 2016
DOIs
Publication statusPublished - 1 Jun 2016

Fingerprint

Type 2 Diabetes Mellitus
Biomarkers
Insulin Resistance
Bilirubin
Accidental Falls
Muscles
Environmental Monitoring
Micronutrients
Hypoglycemia
Computer Simulation
Comorbidity
Urine
Diet

Bibliographical note

-

Keywords

  • ageing
  • falls
  • insulin resistance
  • obesity

Cite this

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abstract = "Type 2 diabetes mellitus (T2DM) increases in prevalence in the elderly. There is evidence for significant muscle loss and accelerated cognitive impairment in older adults with T2DM; these comorbidities are critical features of frailty. In the early stages of T2DM, insulin sensitivity can be improved by a “healthy” diet. Management of insulin resistance by diet in people over 65 years of age should be carefully re-evaluated because of the risk for falling due to hypoglycaemia. To date, an optimal dietary programme for older adults with insulin resistance and T2DM has not been described. The use of biomarkers to identify those at risk for T2DM will enable clinicians to offer early dietary advice that will delay onset of disease and of frailty. Here we have used an in silico literature search for putative novel biomarkers of T2DM risk and frailty. We suggest that plasma bilirubin, plasma, urinary DPP4-positive microparticles and plasma pigment epithelium-derived factor merit further investigation as predictive biomarkers for T2DM and frailty risk in older adults. Bilirubin is screened routinely in clinical practice. Measurement of specific microparticle frequency in urine is less invasive than a blood sample so is a good choice for biomonitoring. Future studies should investigate whether early dietary changes, such as increased intake of whey protein and micronutrients that improve muscle function and insulin sensitivity, affect biomarkers and can reduce the longer term complication of frailty in people at risk for T2DM.",
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Innovative biomarkers for predicting type 2 diabetes mellitus : relevance to dietary management of frailty in older adults. / Ikwuobe, John; Bellary, Srikanth; Griffiths, Helen R.

In: Biogerontology, Vol. 17, No. 3, 01.06.2016, p. 511–527.

Research output: Contribution to journalArticle

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