Insights into membrane interactions and their therapeutic potential

Calum Upton, Joseph Healey, Alice J. Rothnie, Alan D. Goddard

Research output: Contribution to journalArticlepeer-review


Recent research into membrane interactions has uncovered a diverse range of therapeutic opportunities through the bioengineering of human and non-human macromolecules.

Although the majority of this research is focussed on fundamental developments, emerging studies are showcasing promising new technologies to combat conditions such as cancer, Alzheimer's and inflammatory and immune-based disease, utilising the alteration of bacteriophage, adenovirus, bacterial toxins, type 6 secretion systems, annexins, mitochondrial antiviral signalling proteins and bacterial nano-syringes. To advance the field further, each of these opportunities need to be better understood, and the therapeutic models need to be further optimised.

Here, we summarise the knowledge and insights into several membrane interactions and detail their current and potential uses therapeutically.
Original languageEnglish
Article number109939
Number of pages18
JournalArchives of Biochemistry and Biophysics
Early online date21 Feb 2024
Publication statusPublished - May 2024

Bibliographical note

Copyright © 2024 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (


  • Membrane interactions
  • Biotechnology
  • Bacteriophage T4
  • Adenovirus
  • Photorhabdus virulence cassette


Dive into the research topics of 'Insights into membrane interactions and their therapeutic potential'. Together they form a unique fingerprint.

Cite this