Research Output per year
Research Output per year
Dr
United Kingdom
Research output per year
My research interests lie in elucidating the mechanistic functional details of transmembrane and membrane-associated proteins, that do important jobs in the cell, both in health and disease. To date I have predominantly focused on membrane transporter proteins of the ABC superfamily (ATP Binding Cassette), and proteins involved in cellular trafficking, but recently I have expanded this to include secondary active transporters, ion channels and GPCRs (G-protein coupled receptors). By fully understanding exactly how a protein works, we can begin to understand how it goes wrong in disease states and how we might be able to target it therapeutically. To carry out this work I am really keen to develop new methods and techniques that enable us to answer important questions about the target protein, and as such have played a major role in developing the SMALP (styrene maleic acid lipid particle) technology for membrane protein extraction, purification, structural and functional characterization. This approach is now taking off around the world and has led to numerous new collaborations both within academia and industry.
BSc Biological Sciences/Biomedical Science
BY1BC1 - Biochemistry. Module coordinator.
BY2BT2 - Medical Biotechnology.
BSc Biochemistry
BC1003 - Biomolecules. Module coordinator.
BC1001 - Biochemistry Key Skills.
BC2007 - Protein Structure & Function. Module coordinator.
BC2001 - Analytical Biochemistry.
BC2003 - Biochemistry Key Skills II.
BC2004 - Cell membranes & energy generation.
Biosciences Placement Tutor
Phone number: +44 (0)121 204 4013
Email: a.rothnie@aston.ac.uk
Room number: MB455
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Review article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Review article › peer-review
Low, F. (Creator), Shabir, K. (Creator), Brown, J. (Creator), Bill, R. (Creator) & Rothnie, A. (Creator), Aston Data Explorer, 7 Oct 2020
DOI: https://doi.org/10.17036/researchdata.aston.ac.uk.00000483
Dataset
Ayub, H. (Creator), Clare, M. (Creator), Milic, I. (Creator), Chmel, N. P. (Creator), Böning, H. (Creator), Devitt, A. (Creator), Krey, T. (Creator), Bill, R. (Creator) & Rothnie, A. (Creator), Aston Data Explorer, 19 Dec 2019
DOI: 10.17036/researchdata.aston.ac.uk.00000454, https://www.sciencedirect.com/science/article/pii/S0005273620302625
Dataset
Rothnie, A. (Creator), Morrison, K. A. (Creator), Hardy, D. (Creator), Akram, A. (Creator), Mathews, A. (Creator), Khan, Z. (Creator), Patel, J. (Creator), Zhou, C. (Creator), Moore-Kelly, C. (Creator), Patel, R. (Creator), Odiba, V. (Creator), Knowles, T. J. (Creator), Javed, M. (Creator), Chmel, N. (Creator) & Dafforn, T. R. (Creator), Aston Data Explorer, 22 Jul 2016
DOI: 10.17036/ff13833e-68c5-449f-82f2-4f07363fc55d, https://portlandpress.com/biochemj/article/473/23/4349/49306/Membrane-protein-extraction-and-purification-using
Dataset
Rothnie, A. (Creator), Gulamhussein, A. (Creator), Meah, D. (Creator), Fenner, S. (Creator), Saidani, Z. (Creator), Akram, A. (Creator), Lallie, S. (Creator), Mathews, A. (Creator), Liddar, M. (Creator), Mohammed, Z. (Creator), Chiu, L. K. (Creator), Healy, H. (Creator) & Hussain, N. (Creator), Aston Data Explorer, 29 May 2018
DOI: 10.17036/researchdata.aston.ac.uk.00000360, https://www.sciencedirect.com/science/article/pii/S0014305718311832
Dataset
Rothnie, A. (Creator), Gulamhussein, A. (Creator), Meah, D. (Creator), Fenner, S. (Creator), Saidani, Z. (Creator), Akram, A. (Creator), Lallie, S. (Creator), Mathews, A. (Creator), Painter, C. (Creator), Liddar, M. (Creator), Mohammed, Z. (Creator), Chiu, L. K. (Creator), Sumar, S. (Creator), Healy, H. (Creator), Hussain, N. (Creator) & Patel, J. (Creator), Aston Data Explorer, 2019
DOI: 10.17036/researchdata.aston.ac.uk.00000360, https://www.sciencedirect.com/science/article/abs/pii/S0014305718311832?via%3Dihub
Dataset
Rothnie, Alice (Recipient), Aug 2006
Prize: Fellowship awarded competitively
Alice Rothnie (Participant)
Activity: Participating in or organising an event types › Participation in conference
Alice Rothnie (Participant)
Activity: Participating in or organising an event types › Organising a conference, workshop, seminar or course
Alice Rothnie (Recipient)
Activity: Other activity types › Types of Public engagement and outreach - Schools engagement
Alice Rothnie (Speaker)
Activity: Talk or presentation types › Invited talk
Alice Rothnie (Participant)
Activity: Participating in or organising an event types › Participation in conference