Macular pigment optical density in wet age-Related macular degeneration among Indians

R. Raman*, S. Biswas, K. Vaitheeswaran, T. Sharma

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


PurposeTo estimate the value of macular pigment optical density (MPOD) in adult south Indian population with wet age-related macular degeneration (AMD).MethodsA total of 33 patients with wet AMD and 29 age-matched controls 50 years of age underwent MPOD measurement with the macular densitometer. The patients were also tested for their dietary intake of carotenoids, smoking history, and lifetime UV exposure.ResultsThe mean MPOD values in the Indian population with wet AMD was 0.23 (95% CI: 0.18-0.29) vs control was 0.43 (95% CI: 0.37-0.49), P0.0001, at 0.5° eccentricity. Ex-smokers had a lower MPOD than non-smokers (0.16 (0.09-0.23) vs 0.28 (0.22-0.34), P0.026) and the lowest level of carotenoids intake had 48% lower MPOD than the highest level (0.14 (0.08-0.21) vs 0.33 (0.24-0.43), P0.012). There was no significant age-related decline or gender variation in MPOD.ConclusionThis study establishes the MPOD in adult Indian population with wet AMD, with a lack of macular pigment in association with wet AMD.

Original languageEnglish
Pages (from-to)1052-1057
Number of pages6
JournalEye (Basingstoke)
Issue number8
Early online date25 May 2012
Publication statusPublished - Aug 2012


  • age-related macular degeneration
  • carotenoids
  • lutein
  • macular pigment
  • ultraviolet
  • zeaxanthin


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