Metal complexes of carboxamidrazone analogs as antitubercular agents 1. Synthesis, X-ray crystal-structures, spectroscopic properties and antimycobacterial activity against Mycobacterium tuberculosis H37Rv

Uday Sandbhor, Subhash Padhye*, David Billington, Daniel Rathbone, Scott Franzblau, Christopher E. Anson, Annie K. Powell

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

N1-Benzylidene-pyridine carboxamidrazones and their metal conjugates have emerged as a new class of potential antimycobacterial agents. Nine such carboxamidrazone analogs (L1-L9) along with their Cu(II) (MC1-MC9) and Fe(III) (MC10-MC18) complexes were synthesized. Single crystal X-ray structures of copper complexes MC1 and MC5 were determined which suggest slightly distorted square planer geometries for copper complexes and octahedral geometries for ferric compounds. All compounds were evaluated for their in vitro antimycobacterial activity against Mycobacterium tuberculosis H37Rv. The results show 32-64-fold enhancement in antitubercular activity upon copper complexation.

Original languageEnglish
Pages (from-to)127-136
Number of pages10
JournalJournal of Inorganic Biochemistry
Volume90
Issue number3-4
DOIs
Publication statusPublished - 7 Jun 2002

Keywords

  • Carboxamidrazone
  • Metal complexes
  • Tuberculosis
  • X-Ray crystal structure

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