MicroRNA transport in cardiovascular complication of diabetes

Andrea Caporali, Vladislav Miscianinov, Jaimy Saif, Costanza Emanueli

Research output: Contribution to journalReview articlepeer-review

Abstract

MicroRNAs (miRNAs) are post-transcriptional inhibitory regulators of gene expression by binding to complementary messenger RNA (mRNA) transcripts. Extracellular miRNAs are transported by membrane-derived vesicles (exosomes and microparticles), lipoproteins, and other ribonucleoprotein complexes. Extracellular microRNAs are emerging as important mediators of intercellular communications, being involved in the transmission of biological signals between cells. Several miRNAs have been identified as having a primary impact on many biological processes that are of direct relevance to cardiovascular complications of diabetes. Whether the extracellular miRNAs are directly involved in the regulation of these processes is yet to be established. Here, we review recent progresses in extracellular miRNA biology and the role of extracellular miRNA in diabetes induced cardiovascular disease, describing the regulators affecting miRNA transport and the mechanisms for different miRNA transporters. In addition, we discuss the advancement of the research in this field and identify the associated challenges. This article is part of a Special Issue entitled: MicroRNAs and lipid/energy metabolism and related diseases edited by Carlos Fernández-Hernando and Yajaira Suárez.

Original languageEnglish
Pages (from-to)2111-2120
Number of pages10
JournalBBA - Molecular and Cell Biology of Lipids
Volume1861
Issue number12 Pt B
DOIs
Publication statusPublished - 1 Dec 2016

Keywords

  • Animals
  • Biological Transport/physiology
  • Cardiovascular Diseases/metabolism
  • Cell-Derived Microparticles/metabolism
  • Diabetes Mellitus/metabolism
  • Humans
  • MicroRNAs/metabolism

Fingerprint Dive into the research topics of 'MicroRNA transport in cardiovascular complication of diabetes'. Together they form a unique fingerprint.

Cite this