TY - JOUR
T1 - Multimodal prognosis of negative symptom severity in individuals at increased risk of developing psychosis
AU - Hauke, Daniel J.
AU - Schmidt, André
AU - Studerus, Erich
AU - Andreou, Christina
AU - Riecher-Rössler, Anita
AU - Radua, Joaquim
AU - Kambeitz, Joseph
AU - Ruef, Anne
AU - Dwyer, Dominic B.
AU - Kambeitz-Ilankovic, Lana
AU - Lichtenstein, Theresa
AU - Sanfelici, Rachele
AU - Penzel, Nora
AU - Haas, Shalaila S.
AU - Antonucci, Linda A.
AU - Lalousis, Paris Alexandros
AU - Chisholm, Katharine
AU - Schultze-Lutter, Frauke
AU - Ruhrmann, Stephan
AU - Hietala, Jarmo
AU - Brambilla, Paolo
AU - Koutsouleris, Nikolaos
AU - Meisenzahl, Eva
AU - Pantelis, Christos
AU - Rosen, Marlene
AU - Salokangas, Raimo K.R.
AU - Upthegrove, Rachel
AU - Wood, Stephen J.
AU - Borgwardt, Stefan
N1 - Publisher Copyright:
© 2021, The Author(s).
PY - 2021/6
Y1 - 2021/6
N2 - Negative symptoms occur frequently in individuals at clinical high risk (CHR) for psychosis and contribute to functional impairments. The aim of this study was to predict negative symptom severity in CHR after 9 months. Predictive models either included baseline negative symptoms measured with the Structured Interview for Psychosis-Risk Syndromes (SIPS-N), whole-brain gyrification, or both to forecast negative symptoms of at least moderate severity in 94 CHR. We also conducted sequential risk stratification to stratify CHR into different risk groups based on the SIPS-N and gyrification model. Additionally, we assessed the models’ ability to predict functional outcomes in CHR and their transdiagnostic generalizability to predict negative symptoms in 96 patients with recent-onset psychosis (ROP) and 97 patients with recent-onset depression (ROD). Baseline SIPS-N and gyrification predicted moderate/severe negative symptoms with significant balanced accuracies of 68 and 62%, while the combined model achieved 73% accuracy. Sequential risk stratification stratified CHR into a high (83%), medium (40–64%), and low (19%) risk group regarding their risk of having moderate/severe negative symptoms at 9 months follow-up. The baseline SIPS-N model was also able to predict social (61%), but not role functioning (59%) at above-chance accuracies, whereas the gyrification model achieved significant accuracies in predicting both social (76%) and role (74%) functioning in CHR. Finally, only the baseline SIPS-N model showed transdiagnostic generalization to ROP (63%). This study delivers a multimodal prognostic model to identify those CHR with a clinically relevant negative symptom severity and functional impairments, potentially requiring further therapeutic consideration.
AB - Negative symptoms occur frequently in individuals at clinical high risk (CHR) for psychosis and contribute to functional impairments. The aim of this study was to predict negative symptom severity in CHR after 9 months. Predictive models either included baseline negative symptoms measured with the Structured Interview for Psychosis-Risk Syndromes (SIPS-N), whole-brain gyrification, or both to forecast negative symptoms of at least moderate severity in 94 CHR. We also conducted sequential risk stratification to stratify CHR into different risk groups based on the SIPS-N and gyrification model. Additionally, we assessed the models’ ability to predict functional outcomes in CHR and their transdiagnostic generalizability to predict negative symptoms in 96 patients with recent-onset psychosis (ROP) and 97 patients with recent-onset depression (ROD). Baseline SIPS-N and gyrification predicted moderate/severe negative symptoms with significant balanced accuracies of 68 and 62%, while the combined model achieved 73% accuracy. Sequential risk stratification stratified CHR into a high (83%), medium (40–64%), and low (19%) risk group regarding their risk of having moderate/severe negative symptoms at 9 months follow-up. The baseline SIPS-N model was also able to predict social (61%), but not role functioning (59%) at above-chance accuracies, whereas the gyrification model achieved significant accuracies in predicting both social (76%) and role (74%) functioning in CHR. Finally, only the baseline SIPS-N model showed transdiagnostic generalization to ROP (63%). This study delivers a multimodal prognostic model to identify those CHR with a clinically relevant negative symptom severity and functional impairments, potentially requiring further therapeutic consideration.
UR - http://www.scopus.com/inward/record.url?scp=85106950272&partnerID=8YFLogxK
UR - https://www.nature.com/articles/s41398-021-01409-4
U2 - 10.1038/s41398-021-01409-4
DO - 10.1038/s41398-021-01409-4
M3 - Article
C2 - 34031362
AN - SCOPUS:85106950272
SN - 2158-3188
VL - 11
JO - Translational psychiatry
JF - Translational psychiatry
IS - 1
M1 - 312
ER -