Proteomics in the study of hippocampal plasticity

Stuart R. Cobb, Andrew Pitt

Research output: Contribution to journalArticle

Abstract

Synaptic plasticity is the dynamic regulation of the strength of synaptic communication between nerve cells. It is central to neuronal development as well as experience-dependent remodeling of the adult nervous system as occurs during memory formation. Aberrant forms of synaptic plasticity also accompany a variety of neurological and psychiatric diseases, and unraveling the biological basis of synaptic plasticity has been a major goal in neurobiology research. The biochemical and structural mechanisms underlying different forms of synaptic plasticity are complex, involving multiple signaling cascades, reconfigurations of structural proteins and the trafficking of synaptic proteins. As such, proteomics should be a valuable tool in dissecting the molecular events underlying normal and disease-related forms of plasticity. In fact, progress in this area has been disappointingly slow. We discuss the particular challenges associated with proteomic interrogation of synaptic plasticity processes and outline ways in which we believe proteomics may advance the field over the next few years. We pay particular attention to technical advances being made in small sample proteomics and the advent of proteomic imaging in studying brain plasticity.
LanguageEnglish
Pages393-404
Number of pages12
JournalExpert Review of Proteomics
Volume5
Issue number3
DOIs
Publication statusPublished - Jun 2008

Fingerprint

Neuronal Plasticity
Proteomics
Plasticity
Neurobiology
Protein Transport
Nervous System
Psychiatry
Neurology
Communication
Neurons
Brain
Proteins
Research
Imaging techniques
Data storage equipment

Keywords

  • animals
  • hippocampus
  • humans
  • neuronal plasticity
  • proteomics
  • spectrometry
  • synapses
  • mass
  • matrix-assisted laser desorption-ionization

Cite this

Cobb, Stuart R. ; Pitt, Andrew. / Proteomics in the study of hippocampal plasticity. In: Expert Review of Proteomics. 2008 ; Vol. 5, No. 3. pp. 393-404.
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Proteomics in the study of hippocampal plasticity. / Cobb, Stuart R.; Pitt, Andrew.

In: Expert Review of Proteomics, Vol. 5, No. 3, 06.2008, p. 393-404.

Research output: Contribution to journalArticle

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