Recovery of antibiotics from fermentation broth using green solvents

Vesna Najdanovic-Visak, Manuel Nunes da Ponte

Research output: Contribution to conferencePaper

Abstract

Supercritical carbon dioxide and ionic liquids constitute some of possible environmentally friendly alternatives to the conventional organic solvents. Each of these solvents, nevertheless, presents its own disadvantages which comprise their widespread use and application. These shortcomings can probably be overcome by using combinations of these solvents at tuned process conditions.
Here we present preliminary results of recovery of antibiotics from aqueous solutions by using ionic liquids and supercritical carbon dioxide. All selected antibiotics are natural (produced by fermentation) and of industrial importance such as penicillin G, erythromycin, tetracycline and chloramphenicol. Preliminary results indicate possibility of recovering these antibiotics from aqueous media through three stages. First, selection of hydrophobic ionic liquids with good solvent power towards each selected antibiotic molecules has been achieved. As a second step, study of liquid – liquid extraction of an antibiotic from aqueous solution has been performed by an appropriate ionic liquid. As a final step, recovery of antibiotics from ionic liquid medium has been performed by using supercritical carbon dioxide at different pressures and temperatures. Thus, the process design includes coupling aqueous solution – ionic liquid extraction, with: (1) high-pressure carbon-dioxide extraction, followed by crystallization by rapid expansion, or in situ precipitation by a supercritical anti-solvent effect.
Original languageEnglish
Publication statusPublished - 2007
EventI Iberoamerican Conference on Supercritical Fluids, PROSCIBA - Iguassu Falls, Brazil
Duration: 10 Apr 2007 → …

Conference

ConferenceI Iberoamerican Conference on Supercritical Fluids, PROSCIBA
CountryBrazil
CityIguassu Falls
Period10/04/07 → …

Fingerprint

Ionic Liquids
Fermentation
Anti-Bacterial Agents
Carbon Dioxide
Recovery
Penicillin G
Liquids
Chloramphenicol
Erythromycin
Crystallization
Tetracycline
Organic solvents
Process design
Molecules

Cite this

Najdanovic-Visak, V., & Ponte, M. N. D. (2007). Recovery of antibiotics from fermentation broth using green solvents. Paper presented at I Iberoamerican Conference on Supercritical Fluids, PROSCIBA, Iguassu Falls, Brazil.
Najdanovic-Visak, Vesna ; Ponte, Manuel Nunes da. / Recovery of antibiotics from fermentation broth using green solvents. Paper presented at I Iberoamerican Conference on Supercritical Fluids, PROSCIBA, Iguassu Falls, Brazil.
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Najdanovic-Visak, V & Ponte, MND 2007, 'Recovery of antibiotics from fermentation broth using green solvents', Paper presented at I Iberoamerican Conference on Supercritical Fluids, PROSCIBA, Iguassu Falls, Brazil, 10/04/07.

Recovery of antibiotics from fermentation broth using green solvents. / Najdanovic-Visak, Vesna; Ponte, Manuel Nunes da.

2007. Paper presented at I Iberoamerican Conference on Supercritical Fluids, PROSCIBA, Iguassu Falls, Brazil.

Research output: Contribution to conferencePaper

TY - CONF

T1 - Recovery of antibiotics from fermentation broth using green solvents

AU - Najdanovic-Visak, Vesna

AU - Ponte, Manuel Nunes da

PY - 2007

Y1 - 2007

N2 - Supercritical carbon dioxide and ionic liquids constitute some of possible environmentally friendly alternatives to the conventional organic solvents. Each of these solvents, nevertheless, presents its own disadvantages which comprise their widespread use and application. These shortcomings can probably be overcome by using combinations of these solvents at tuned process conditions. Here we present preliminary results of recovery of antibiotics from aqueous solutions by using ionic liquids and supercritical carbon dioxide. All selected antibiotics are natural (produced by fermentation) and of industrial importance such as penicillin G, erythromycin, tetracycline and chloramphenicol. Preliminary results indicate possibility of recovering these antibiotics from aqueous media through three stages. First, selection of hydrophobic ionic liquids with good solvent power towards each selected antibiotic molecules has been achieved. As a second step, study of liquid – liquid extraction of an antibiotic from aqueous solution has been performed by an appropriate ionic liquid. As a final step, recovery of antibiotics from ionic liquid medium has been performed by using supercritical carbon dioxide at different pressures and temperatures. Thus, the process design includes coupling aqueous solution – ionic liquid extraction, with: (1) high-pressure carbon-dioxide extraction, followed by crystallization by rapid expansion, or in situ precipitation by a supercritical anti-solvent effect.

AB - Supercritical carbon dioxide and ionic liquids constitute some of possible environmentally friendly alternatives to the conventional organic solvents. Each of these solvents, nevertheless, presents its own disadvantages which comprise their widespread use and application. These shortcomings can probably be overcome by using combinations of these solvents at tuned process conditions. Here we present preliminary results of recovery of antibiotics from aqueous solutions by using ionic liquids and supercritical carbon dioxide. All selected antibiotics are natural (produced by fermentation) and of industrial importance such as penicillin G, erythromycin, tetracycline and chloramphenicol. Preliminary results indicate possibility of recovering these antibiotics from aqueous media through three stages. First, selection of hydrophobic ionic liquids with good solvent power towards each selected antibiotic molecules has been achieved. As a second step, study of liquid – liquid extraction of an antibiotic from aqueous solution has been performed by an appropriate ionic liquid. As a final step, recovery of antibiotics from ionic liquid medium has been performed by using supercritical carbon dioxide at different pressures and temperatures. Thus, the process design includes coupling aqueous solution – ionic liquid extraction, with: (1) high-pressure carbon-dioxide extraction, followed by crystallization by rapid expansion, or in situ precipitation by a supercritical anti-solvent effect.

M3 - Paper

ER -

Najdanovic-Visak V, Ponte MND. Recovery of antibiotics from fermentation broth using green solvents. 2007. Paper presented at I Iberoamerican Conference on Supercritical Fluids, PROSCIBA, Iguassu Falls, Brazil.