The application of monolayer studies in the understanding of liposomal formulations

Behfar Moghaddam, Habib Ali, Jitinder Wilkhu, Daniel J Kirby, Afzal-Ur-Rahman Mohammed, Qinguo Zheng, Yvonne Perrie

Research output: Contribution to journalArticle

Abstract

The study of surfactant monolayers is certainly not a new technique, but the application of monolayer studies to elucidate controlling factors in liposome design remains an underutilised resource. Using a Langmuir-Blodgett trough, pure and mixed lipid monolayers can be investigated, both for their interactions within the monolayer, and for interfacial interactions with drugs in the aqueous sub-phase. Despite these monolayers effectively being only half a bilayer, with a flat rather than curved structure, information from these studies can be effectively translated into liposomal systems. Here we outline the background, general protocols and application of Langmuir studies with a focus on their application in liposomal systems. A range of case studies are discussed which show how the system can be used to support its application in the development of liposome drug delivery. Examples include investigations into the effect of cholesterol within the liposome bilayer, understanding effective lipid packaging within the bilayer to promote water soluble and poorly soluble drug retention, the effect of alkyl chain length on lipid packaging, and drug-monolayer electrostatic interactions that promote bilayer repackaging.
LanguageEnglish
Pages235-244
Number of pages10
JournalInternational Journal of Pharmaceutics
Volume417
Issue number1-2
Early online date18 Jan 2011
DOIs
Publication statusPublished - 30 Sep 2011

Fingerprint

Liposomes
Lipids
Drug Packaging
Product Packaging
Static Electricity
Drug Interactions
Surface-Active Agents
Pharmaceutical Preparations
Cholesterol
Water

Keywords

  • pharmaceutical chemistry
  • drug delivery systems
  • lipid bilayers
  • liposomes
  • unilamellar liposomes

Cite this

Moghaddam, Behfar ; Ali, Habib ; Wilkhu, Jitinder ; Kirby, Daniel J ; Mohammed, Afzal-Ur-Rahman ; Zheng, Qinguo ; Perrie, Yvonne. / The application of monolayer studies in the understanding of liposomal formulations. In: International Journal of Pharmaceutics. 2011 ; Vol. 417, No. 1-2. pp. 235-244.
@article{7e63f6ce462e42d199b0926331c65264,
title = "The application of monolayer studies in the understanding of liposomal formulations",
abstract = "The study of surfactant monolayers is certainly not a new technique, but the application of monolayer studies to elucidate controlling factors in liposome design remains an underutilised resource. Using a Langmuir-Blodgett trough, pure and mixed lipid monolayers can be investigated, both for their interactions within the monolayer, and for interfacial interactions with drugs in the aqueous sub-phase. Despite these monolayers effectively being only half a bilayer, with a flat rather than curved structure, information from these studies can be effectively translated into liposomal systems. Here we outline the background, general protocols and application of Langmuir studies with a focus on their application in liposomal systems. A range of case studies are discussed which show how the system can be used to support its application in the development of liposome drug delivery. Examples include investigations into the effect of cholesterol within the liposome bilayer, understanding effective lipid packaging within the bilayer to promote water soluble and poorly soluble drug retention, the effect of alkyl chain length on lipid packaging, and drug-monolayer electrostatic interactions that promote bilayer repackaging.",
keywords = "pharmaceutical chemistry, drug delivery systems, lipid bilayers, liposomes, unilamellar liposomes",
author = "Behfar Moghaddam and Habib Ali and Jitinder Wilkhu and Kirby, {Daniel J} and Afzal-Ur-Rahman Mohammed and Qinguo Zheng and Yvonne Perrie",
note = "Copyright {\circledC} 2011 Elsevier B.V. All rights reserved.",
year = "2011",
month = "9",
day = "30",
doi = "10.1016/j.ijpharm.2011.01.020",
language = "English",
volume = "417",
pages = "235--244",
journal = "International Journal of Pharmaceutics",
issn = "0378-5173",
publisher = "Elsevier",
number = "1-2",

}

The application of monolayer studies in the understanding of liposomal formulations. / Moghaddam, Behfar; Ali, Habib; Wilkhu, Jitinder; Kirby, Daniel J; Mohammed, Afzal-Ur-Rahman; Zheng, Qinguo; Perrie, Yvonne.

In: International Journal of Pharmaceutics, Vol. 417, No. 1-2, 30.09.2011, p. 235-244.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The application of monolayer studies in the understanding of liposomal formulations

AU - Moghaddam, Behfar

AU - Ali, Habib

AU - Wilkhu, Jitinder

AU - Kirby, Daniel J

AU - Mohammed, Afzal-Ur-Rahman

AU - Zheng, Qinguo

AU - Perrie, Yvonne

N1 - Copyright © 2011 Elsevier B.V. All rights reserved.

PY - 2011/9/30

Y1 - 2011/9/30

N2 - The study of surfactant monolayers is certainly not a new technique, but the application of monolayer studies to elucidate controlling factors in liposome design remains an underutilised resource. Using a Langmuir-Blodgett trough, pure and mixed lipid monolayers can be investigated, both for their interactions within the monolayer, and for interfacial interactions with drugs in the aqueous sub-phase. Despite these monolayers effectively being only half a bilayer, with a flat rather than curved structure, information from these studies can be effectively translated into liposomal systems. Here we outline the background, general protocols and application of Langmuir studies with a focus on their application in liposomal systems. A range of case studies are discussed which show how the system can be used to support its application in the development of liposome drug delivery. Examples include investigations into the effect of cholesterol within the liposome bilayer, understanding effective lipid packaging within the bilayer to promote water soluble and poorly soluble drug retention, the effect of alkyl chain length on lipid packaging, and drug-monolayer electrostatic interactions that promote bilayer repackaging.

AB - The study of surfactant monolayers is certainly not a new technique, but the application of monolayer studies to elucidate controlling factors in liposome design remains an underutilised resource. Using a Langmuir-Blodgett trough, pure and mixed lipid monolayers can be investigated, both for their interactions within the monolayer, and for interfacial interactions with drugs in the aqueous sub-phase. Despite these monolayers effectively being only half a bilayer, with a flat rather than curved structure, information from these studies can be effectively translated into liposomal systems. Here we outline the background, general protocols and application of Langmuir studies with a focus on their application in liposomal systems. A range of case studies are discussed which show how the system can be used to support its application in the development of liposome drug delivery. Examples include investigations into the effect of cholesterol within the liposome bilayer, understanding effective lipid packaging within the bilayer to promote water soluble and poorly soluble drug retention, the effect of alkyl chain length on lipid packaging, and drug-monolayer electrostatic interactions that promote bilayer repackaging.

KW - pharmaceutical chemistry

KW - drug delivery systems

KW - lipid bilayers

KW - liposomes

KW - unilamellar liposomes

UR - http://www.scopus.com/inward/record.url?scp=80052272786&partnerID=8YFLogxK

U2 - 10.1016/j.ijpharm.2011.01.020

DO - 10.1016/j.ijpharm.2011.01.020

M3 - Article

VL - 417

SP - 235

EP - 244

JO - International Journal of Pharmaceutics

T2 - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

SN - 0378-5173

IS - 1-2

ER -