The dyslexia candidate locus on 2p12 is associated with general cognitive ability and white matter structure

Thomas S. Scerri, Fahimeh Darki, Dianne F. Newbury, Andrew J.O. Whitehouse, Myriam Peyrard-Janvid, Hans Matsson, Qi W. Ang, Craig E. Pennell, Susan Ring, John Stein, Andrew P. Morris, Anthony P. Monaco, Juha Kere, Joel Talcott, Torkel Klingberg, Silvia Paracchini

Research output: Contribution to journalArticlepeer-review

Abstract

Independent studies have shown that candidate genes for dyslexia and specific language impairment (SLI) impact upon reading/language-specific traits in the general population. To further explore the effect of disorder-associated genes on cognitive functions, we investigated whether they play a role in broader cognitive traits. We tested a panel of dyslexia and SLI genetic risk factors for association with two measures of general cognitive abilities, or IQ, (verbal and non-verbal) in the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort (N>5,000). Only the MRPL19/C2ORF3 locus showed statistically significant association (minimum P = 0.00009) which was further supported by independent replications following analysis in four other cohorts. In addition, a fifth independent sample showed association between the MRPL19/C2ORF3 locus and white matter structure in the posterior part of the corpus callosum and cingulum, connecting large parts of the cortex in the parietal, occipital and temporal lobes. These findings suggest that this locus, originally identified as being associated with dyslexia, is likely to harbour genetic variants associated with general cognitive abilities by influencing white matter structure in localised neuronal regions.

Original languageEnglish
Article numbere50321
Number of pages8
JournalPLoS ONE
Volume7
Issue number11
DOIs
Publication statusPublished - 28 Nov 2012

Bibliographical note

© 2012 Scerri et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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