The emergence of frailty and sarcopaenia in diabetes mellitus: Description of inter-relationships and clinical importance

Alan J. Sinclair*, Harriet Sinclair, Srikanth Bellary, Leocadio Rodriguez-Manas

*Corresponding author for this work

Research output: Contribution to journalReview article

Abstract

Diabetes mellitus is a highly prevalent chronic disease, with an associated heavy personal and public health burden of disability, morbidity and mortality. The focus of care for older patients with diabetes is prevention of functional decline, with early intervention rather than attempting to recover function later. Diabetes doubles the risk of frailty. An important contributor towards physical frailty is sarcopaenia, which manifests as an age-related loss of skeletal muscle volume and power. Frailty is not an inevitable consequence of the ageing process; it is a dynamic and potentially reversible condition that highlights the importance of early recognition and intervention. In this review, we examine the evidence for linking diabetes to frailty and sarcopaenia and how the emergence of these conditions should lead to changes in clinician behaviour in terms of assessment of function and goal setting. High-quality, focused research in this area is now mandatory.

Original languageEnglish
Pages (from-to)40-50
Number of pages11
JournalCardiovascular Endocrinology
Volume5
Issue number2
DOIs
Publication statusPublished - 1 Apr 2016

Fingerprint

Patient Care
Diabetes Mellitus
Skeletal Muscle
Chronic Disease
Public Health
Morbidity
Mortality
Research

Keywords

  • ageing
  • diabetes mellitus
  • disability
  • frailty
  • functional impairment
  • sarcopaenia

Cite this

Sinclair, Alan J. ; Sinclair, Harriet ; Bellary, Srikanth ; Rodriguez-Manas, Leocadio. / The emergence of frailty and sarcopaenia in diabetes mellitus : Description of inter-relationships and clinical importance. In: Cardiovascular Endocrinology. 2016 ; Vol. 5, No. 2. pp. 40-50.
@article{cebd50eed11c4ee684e6127c90e7c3fa,
title = "The emergence of frailty and sarcopaenia in diabetes mellitus: Description of inter-relationships and clinical importance",
abstract = "Diabetes mellitus is a highly prevalent chronic disease, with an associated heavy personal and public health burden of disability, morbidity and mortality. The focus of care for older patients with diabetes is prevention of functional decline, with early intervention rather than attempting to recover function later. Diabetes doubles the risk of frailty. An important contributor towards physical frailty is sarcopaenia, which manifests as an age-related loss of skeletal muscle volume and power. Frailty is not an inevitable consequence of the ageing process; it is a dynamic and potentially reversible condition that highlights the importance of early recognition and intervention. In this review, we examine the evidence for linking diabetes to frailty and sarcopaenia and how the emergence of these conditions should lead to changes in clinician behaviour in terms of assessment of function and goal setting. High-quality, focused research in this area is now mandatory.",
keywords = "ageing, diabetes mellitus, disability, frailty, functional impairment, sarcopaenia",
author = "Sinclair, {Alan J.} and Harriet Sinclair and Srikanth Bellary and Leocadio Rodriguez-Manas",
year = "2016",
month = "4",
day = "1",
doi = "10.1097/XCE.0000000000000075",
language = "English",
volume = "5",
pages = "40--50",
number = "2",

}

The emergence of frailty and sarcopaenia in diabetes mellitus : Description of inter-relationships and clinical importance. / Sinclair, Alan J.; Sinclair, Harriet; Bellary, Srikanth; Rodriguez-Manas, Leocadio.

In: Cardiovascular Endocrinology, Vol. 5, No. 2, 01.04.2016, p. 40-50.

Research output: Contribution to journalReview article

TY - JOUR

T1 - The emergence of frailty and sarcopaenia in diabetes mellitus

T2 - Description of inter-relationships and clinical importance

AU - Sinclair, Alan J.

AU - Sinclair, Harriet

AU - Bellary, Srikanth

AU - Rodriguez-Manas, Leocadio

PY - 2016/4/1

Y1 - 2016/4/1

N2 - Diabetes mellitus is a highly prevalent chronic disease, with an associated heavy personal and public health burden of disability, morbidity and mortality. The focus of care for older patients with diabetes is prevention of functional decline, with early intervention rather than attempting to recover function later. Diabetes doubles the risk of frailty. An important contributor towards physical frailty is sarcopaenia, which manifests as an age-related loss of skeletal muscle volume and power. Frailty is not an inevitable consequence of the ageing process; it is a dynamic and potentially reversible condition that highlights the importance of early recognition and intervention. In this review, we examine the evidence for linking diabetes to frailty and sarcopaenia and how the emergence of these conditions should lead to changes in clinician behaviour in terms of assessment of function and goal setting. High-quality, focused research in this area is now mandatory.

AB - Diabetes mellitus is a highly prevalent chronic disease, with an associated heavy personal and public health burden of disability, morbidity and mortality. The focus of care for older patients with diabetes is prevention of functional decline, with early intervention rather than attempting to recover function later. Diabetes doubles the risk of frailty. An important contributor towards physical frailty is sarcopaenia, which manifests as an age-related loss of skeletal muscle volume and power. Frailty is not an inevitable consequence of the ageing process; it is a dynamic and potentially reversible condition that highlights the importance of early recognition and intervention. In this review, we examine the evidence for linking diabetes to frailty and sarcopaenia and how the emergence of these conditions should lead to changes in clinician behaviour in terms of assessment of function and goal setting. High-quality, focused research in this area is now mandatory.

KW - ageing

KW - diabetes mellitus

KW - disability

KW - frailty

KW - functional impairment

KW - sarcopaenia

UR - http://www.scopus.com/inward/record.url?scp=85006228048&partnerID=8YFLogxK

U2 - 10.1097/XCE.0000000000000075

DO - 10.1097/XCE.0000000000000075

M3 - Review article

AN - SCOPUS:85006228048

VL - 5

SP - 40

EP - 50

IS - 2

ER -