The evolving state of cardiac resynchronization therapy and conduction system pacing: 25 years of research at EP Europace journal

Kenneth A. Ellenbogen; Angelo Auricchio; Haran Burri; Michael R. Gold; Christophe Leclercq; Francisco Leyva; Cecilia Linde; Marek Jastrzebski; Frits Prinzen; Kevin Vernooy

doi:10.1093/europace/euad168

The evolving state of cardiac resynchronization therapy and conduction system pacing: 25 years of research at EP Europace journal

Kenneth A. Ellenbogen, Angelo Auricchio, Haran Burri, Michael R. Gold, Christophe Leclercq, Francisco Leyva, Cecilia Linde, Marek Jastrzebski, Frits Prinzen, Kevin Vernooy

Research output: Contribution to journal › Review article › peer-review

Abstract

Cardiac resynchronization therapy (CRT) was proposed in the 1990s as a new therapy for patients with heart failure and wide QRS with depressed left ventricular ejection fraction despite optimal medical treatment. This review is aimed first to describe the rationale and the physiologic effects of CRT. The journey of the landmark randomized trials leading to the adoption of CRT in the guidelines since 2005 is also reported showing the high level of evidence for CRT. Different alternative pacing modalities of CRT to conventional left ventricular pacing through the coronary sinus have been proposed to increase the response rate to CRT such as multisite pacing and endocardial pacing. A new emerging alternative technique to conventional biventricular pacing, conduction system pacing (CSP), is a promising therapy. The different modalities of CSP are described (Hirs pacing and left bundle branch area pacing). This new technique has to be evaluated in clinical randomized trials before implementation in the guidelines with a high level of evidence.

Original language	English
Article number	euad168
Number of pages	16
Journal	Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology
Volume	25
Issue number	8
Early online date	25 Aug 2023
DOIs	https://doi.org/10.1093/europace/euad168
Publication status	Published - 25 Aug 2023

Bibliographical note

Copyright © The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

Keywords

Cardiac conduction system pacing
Cardiac resynchronization therapy
Clinical trials
Stroke Volume
Ventricular Function, Left
Humans
Heart Conduction System
Cardiac Conduction System Disease
Cardiac Resynchronization Therapy

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10.1093/europace/euad168Licence: CC BY-NC 4.0

Ellenbogen et al_evolving state of cardiac resynchronization therapy and conduction system pacing_25 years of EP Europace research
Copyright © The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
Final published version, 6.32 MBLicence: CC BY-NC 4.0

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Ellenbogen, K. A., Auricchio, A., Burri, H., Gold, M. R., Leclercq, C., Leyva, F., Linde, C., Jastrzebski, M., Prinzen, F., & Vernooy, K. (2023). The evolving state of cardiac resynchronization therapy and conduction system pacing: 25 years of research at EP Europace journal. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 25(8), Article euad168. https://doi.org/10.1093/europace/euad168

Ellenbogen, Kenneth A. ; Auricchio, Angelo ; Burri, Haran et al. / The evolving state of cardiac resynchronization therapy and conduction system pacing: 25 years of research at EP Europace journal. In: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology. 2023 ; Vol. 25, No. 8.

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title = "The evolving state of cardiac resynchronization therapy and conduction system pacing: 25 years of research at EP Europace journal",

abstract = "Cardiac resynchronization therapy (CRT) was proposed in the 1990s as a new therapy for patients with heart failure and wide QRS with depressed left ventricular ejection fraction despite optimal medical treatment. This review is aimed first to describe the rationale and the physiologic effects of CRT. The journey of the landmark randomized trials leading to the adoption of CRT in the guidelines since 2005 is also reported showing the high level of evidence for CRT. Different alternative pacing modalities of CRT to conventional left ventricular pacing through the coronary sinus have been proposed to increase the response rate to CRT such as multisite pacing and endocardial pacing. A new emerging alternative technique to conventional biventricular pacing, conduction system pacing (CSP), is a promising therapy. The different modalities of CSP are described (Hirs pacing and left bundle branch area pacing). This new technique has to be evaluated in clinical randomized trials before implementation in the guidelines with a high level of evidence.",

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note = "Copyright {\textcopyright} The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com",

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Ellenbogen, KA, Auricchio, A, Burri, H, Gold, MR, Leclercq, C, Leyva, F, Linde, C, Jastrzebski, M, Prinzen, F & Vernooy, K 2023, 'The evolving state of cardiac resynchronization therapy and conduction system pacing: 25 years of research at EP Europace journal', Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, vol. 25, no. 8, euad168. https://doi.org/10.1093/europace/euad168

The evolving state of cardiac resynchronization therapy and conduction system pacing: 25 years of research at EP Europace journal. / Ellenbogen, Kenneth A.; Auricchio, Angelo; Burri, Haran et al.
In: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Vol. 25, No. 8, euad168, 25.08.2023.

Research output: Contribution to journal › Review article › peer-review

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T1 - The evolving state of cardiac resynchronization therapy and conduction system pacing: 25 years of research at EP Europace journal

AU - Ellenbogen, Kenneth A.

AU - Auricchio, Angelo

AU - Burri, Haran

AU - Gold, Michael R.

AU - Leclercq, Christophe

AU - Leyva, Francisco

AU - Linde, Cecilia

AU - Jastrzebski, Marek

AU - Prinzen, Frits

AU - Vernooy, Kevin

N1 - Copyright © The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

PY - 2023/8/25

Y1 - 2023/8/25

N2 - Cardiac resynchronization therapy (CRT) was proposed in the 1990s as a new therapy for patients with heart failure and wide QRS with depressed left ventricular ejection fraction despite optimal medical treatment. This review is aimed first to describe the rationale and the physiologic effects of CRT. The journey of the landmark randomized trials leading to the adoption of CRT in the guidelines since 2005 is also reported showing the high level of evidence for CRT. Different alternative pacing modalities of CRT to conventional left ventricular pacing through the coronary sinus have been proposed to increase the response rate to CRT such as multisite pacing and endocardial pacing. A new emerging alternative technique to conventional biventricular pacing, conduction system pacing (CSP), is a promising therapy. The different modalities of CSP are described (Hirs pacing and left bundle branch area pacing). This new technique has to be evaluated in clinical randomized trials before implementation in the guidelines with a high level of evidence.

AB - Cardiac resynchronization therapy (CRT) was proposed in the 1990s as a new therapy for patients with heart failure and wide QRS with depressed left ventricular ejection fraction despite optimal medical treatment. This review is aimed first to describe the rationale and the physiologic effects of CRT. The journey of the landmark randomized trials leading to the adoption of CRT in the guidelines since 2005 is also reported showing the high level of evidence for CRT. Different alternative pacing modalities of CRT to conventional left ventricular pacing through the coronary sinus have been proposed to increase the response rate to CRT such as multisite pacing and endocardial pacing. A new emerging alternative technique to conventional biventricular pacing, conduction system pacing (CSP), is a promising therapy. The different modalities of CSP are described (Hirs pacing and left bundle branch area pacing). This new technique has to be evaluated in clinical randomized trials before implementation in the guidelines with a high level of evidence.

KW - Cardiac conduction system pacing

KW - Cardiac resynchronization therapy

KW - Clinical trials

KW - Stroke Volume

KW - Ventricular Function, Left

KW - Humans

KW - Heart Conduction System

KW - Cardiac Conduction System Disease

KW - Cardiac Resynchronization Therapy

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Ellenbogen KA, Auricchio A, Burri H, Gold MR, Leclercq C, Leyva F et al. The evolving state of cardiac resynchronization therapy and conduction system pacing: 25 years of research at EP Europace journal. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology. 2023 Aug 25;25(8):euad168. Epub 2023 Aug 25. doi: 10.1093/europace/euad168

The evolving state of cardiac resynchronization therapy and conduction system pacing: 25 years of research at EP Europace journal

Abstract

Bibliographical note

Keywords

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