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Personal profile

General

I joined the school of Life and Health Sciences at Aston university as a lecturer in Cell Biology in November 2009 following on from a similar post at Liverpool John Moores University for 2 years (from 2007). It is in the USA that I started being fascinated by the world of Cell Biology when I undertook my postdoctoral studies at the University of Medicine and Dentistry of New Jersey (UMDNJ). It is within these 7 years (2000-2007) that I realised the biological significance of the cellular organisation and their roles in both physiological and diseases states. Prior to this, I received my PhD from the Nottingham Trent University where I graduated in 2000 following on from 3 years of work in the field of Biochemistry. My degrees both from the Nottingham Trent University (applied Biology in 1996) and from Paris XII Creteil (applied biology 1994) were really the steps that took me into the world of science and biology and were the foundations of my career.

Research Interests

The research in our laboratory aims to characterise the role, at the cellular level, of different actin binding/bundling proteins on the organisation of the actin cytoskeleton and the potential roles these proteins may have in disease progressions, such as cancer and complicated pregnancies.

Our recent work focuses on proteins that have been linked to cancer progression and have been shown to enhance cellular migration, leading to a metastatic phenotype when it is over expressed in certain tumour cells.We have also now focused on deciphering the more physiological functions of these proteins in the context of healthy living and try to understand more about their roles in normal lives.

Our work and that of others has shown that both S100P and S100A4 affect the actin cytoskeleton though interaction with the non muscle myosin network. Using cell culture and state of the art facilities in cellular biology and molecular biology, we aim to understand the molecular mechanisms that allow these S100 proteins to remodel the actin cytoskeleton and the consequences of such reorganisation on cell migration. and mammalian systems as well as in vitro using the state of the art facilities in cellular biology and molecular biology offered in our department.

Employment

  • 2000-2005 Postdoctoral Research Fellow, University of Medicine and Dentistry of New Jersey (USA) 
  • 2005-2007 Adjunct Assistant Professor, University of Medicine and Dentistry of New Jersey (USA) 
  • 2007-2009 Lecturer in Cellular and Molecular Biology, Liverpool John Moores University (UK) 
  • 2009 –     Lecturer in Cellular Biology, Aston University  

Qualifications

  • 1994-1996 Diplome Universitaire de Technologie in Applied Biology, IUT Creteil Paris XII (France) 
  • 1994-1996 BSc. (Hon) Biological Sciences, Nottingham Trent University  
  • 1997-2000 PhD in Biochemistry, Nottingham Trent University  
  • 2007-2008 Postgraduate Certificate in Higher Education, Liverpool John Moores University 

Contact Details

Room: MB343A
Tel: +44 (0) 121 204 3467
email: s.r.gross@aston.ac.uk
Contact me by clicking HERE

External positions

External examiner for Bioscience programme

1 Feb 201831 Jan 2022

external examiner for PhD vivas

Keywords

  • QH301 Biology
  • cells

Fingerprint Dive into the research topics where Stephane Gross is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 3 Similar Profiles
Actin Cytoskeleton Medicine & Life Sciences
Cell Movement Medicine & Life Sciences
Yeast Chemical Compounds
Peptide Elongation Factors Medicine & Life Sciences
Proteins Medicine & Life Sciences
Actins Medicine & Life Sciences
Eukaryotic Initiation Factors Medicine & Life Sciences
Fibronectins Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2002 2018

  • 25 Article
  • 1 Chapter (peer-reviewed)
  • 1 Comment/debate
  • 1 Review article

Downregulation of aquaporin 3 inhibits cellular proliferation, migration and invasion in the MDA‑MB‑231 breast cancer cell line

Arif, M., Kitchen, P., Conner, M., Hill, E., Nagel, D., Bill, R., Dunmore, S., Armesilla, A., Gross, S., Carmichael, A., Conner, A. & Brown, J., May 2018, In : Oncology Letters. 16, 1, p. 713-720

Research output: Contribution to journalArticle

Open Access
File
Aquaporin 3
Aquaporins
Aquaglyceroporins
Glycerol
Gene Knockdown Techniques

Microbial expression systems for membrane proteins

Dilworth, M. V., Piel, M. S., Bettaney, K. E., Ma, P., Luo, J., Sharples, D., Poyner, D. R., Gross, S. R., Moncoq, K., J. F. Henderson, P., Miroux, B. & Bill, R. M., 12 Apr 2018, In : Methods.

Research output: Contribution to journalArticle

Open Access
File
Membrane Proteins
Genetic engineering
Proteins
Recombinant DNA
Crystallization

S100P enhances the motility and invasion of human trophoblast cell lines

Ebrahimzadeh Asl Tabrizi, M., Lancaster, T., Ismail, T. M., Ganguly, A., Georgiadou, A., Wang, K., Rudland, P. S., Ahmad, S. S. & Gross, S. R., 31 Jul 2018, In : Scientific Reports. 8, 11488.

Research output: Contribution to journalArticle

Open Access
File
Trophoblasts
First Pregnancy Trimester
Cell Movement
Physiological Phenomena
Cell Line

The anti-psychotic drug Pimozide is a Novel chemotherapeutic for Breast Cancer

El-Habib, D., Pickard, A., Sirvastava, K., Mc Crudden, C., Gross, S. R., Llyod, S., Zhang, S-D., Margariti, A., Morgan, R., Rudland, P. S. & El-Tanani, M., 9 Oct 2018, In : Oncotarget. 9, 79, p. 34889-34910

Research output: Contribution to journalArticle

Open Access
File
Pimozide
Breast Neoplasms
Pharmaceutical Preparations
Lung Neoplasms
Down-Regulation

Activation of tissue plasminogen activator by metastasis-inducing S100P protein

Clarke, C., Gross, S. R., Ismail, T., Rudland, P., Al-Medhtiy, M., Santangeli, M. & Barraclough, R., 12 Sep 2017, In : Biochemical Journal. 474, 19, p. 3227-3240 14 p., BCJ20170578.

Research output: Contribution to journalArticle

Open Access
File
Tissue Plasminogen Activator
Lysine
Plasminogen
Chemical activation
Neoplasm Metastasis

Thesis

Cellular and molecular consequences of S100A4-induced motility in rat breast tumour Rama 37 cells

Author: Sin, C., 22 Nov 2013

Supervisor: Gross, S. R. (Supervisor) & Griffin, M. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File

Novel strategies to improve recombinant membrane protein production in yeast

Author: Dilworth, M., 2 Aug 2014

Supervisor: Bill, R. M. (Supervisor) & Gross, S. R. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File

Regulating the expression of eEF1A to decipher its non canonical functions in eukaryotic cells

Author: Hallbrook, K., 7 Jul 2015

Supervisor: Gross, S. R. (Supervisor), Hoffmann, B. (Supervisor) & Bill, R. M. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File

The Role of Aquaporin 3 (AQP3) in Breast Cancer

Author: Arif, M., 25 Jun 2014

Supervisor: Brown, J. E. (Supervisor) & Gross, S. R. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File

Activities 2008 2012

  • 1 Participation in conference
  • 1 Publication peer-review
  • 1 Types of Public engagement and outreach - Schools engagement

Midland Biophysics Network Symposium 2012 Towards Novel Drug Targets

Stephane Gross (Organiser)
18 Apr 2012

Activity: Participating in or organising an event typesParticipation in conference

Masterclass

Stephane Gross (Organiser)
2011 → …

Activity: Other activity typesTypes of Public engagement and outreach - Schools engagement

Biochemical Journal (Journal)

Stephane Gross (Peer reviewer)
20082012

Activity: Publication peer-review and editorial work typesPublication peer-review