Abstract
Original language | English |
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DOIs | |
Publication status | Published - 29 Feb 2016 |
Event | SPIE BiOS, 2016, San Francisco, California, United States - Duration: 29 Feb 2016 → … |
Conference
Conference | SPIE BiOS, 2016, San Francisco, California, United States |
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Period | 29/02/16 → … |
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Bibliographical note
© (2016) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE).Cite this
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A pilot study using laser-based technique for non-invasive diagnostics of hypertensive conditions in mice. / Choi, Bernard (Editor); Kollias, Nikiforos (Editor); Zeng, Haishan (Editor); Kang, Hyun Wook (Editor); Wong, Brian J. F. (Editor); Ilgner, Justus F. (Editor); Tearney, Guillermo J. (Editor); Gregory, Kenton W. (Editor); Marcu, Laura (Editor); Skala, Melissa C. (Editor); Campagnola, Paul J. (Editor); Mandelis, Andreas (Editor); Morris, Michael D. (Editor); Litvinova, Karina S.; Ahmad, Shakil; Wang, Keqing; Rafailov, Ilya E.; Sokolovski, Sergei G.; Zhang, Lin; Rafailov, Edik U.; Ahmed, Asif.
2016. SPIE BiOS, 2016, San Francisco, California, United States, .Research output: Contribution to conference › Other
TY - CONF
T1 - A pilot study using laser-based technique for non-invasive diagnostics of hypertensive conditions in mice
AU - Litvinova, Karina S.
AU - Ahmad, Shakil
AU - Wang, Keqing
AU - Rafailov, Ilya E.
AU - Sokolovski, Sergei G.
AU - Zhang, Lin
AU - Rafailov, Edik U.
AU - Ahmed, Asif
A2 - Choi, Bernard
A2 - Kollias, Nikiforos
A2 - Zeng, Haishan
A2 - Kang, Hyun Wook
A2 - Wong, Brian J. F.
A2 - Ilgner, Justus F.
A2 - Tearney, Guillermo J.
A2 - Gregory, Kenton W.
A2 - Marcu, Laura
A2 - Skala, Melissa C.
A2 - Campagnola, Paul J.
A2 - Mandelis, Andreas
A2 - Morris, Michael D.
N1 - © (2016) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE).
PY - 2016/2/29
Y1 - 2016/2/29
N2 - Endothelial dysfunction is directly linked to preeclampsia, a maternal hypertensive condition that is life threating for both the mother and the baby. Epidemiological studies show that women with a history of pre-eclampsia have an elevated risk for cardiovascular disease. Here we report a new non-invasive diagnostic test for preeclampsia in mice that allows us to non-invasively assess the condition of the animals during the experiment and treatment in established models of preeclampsia. A laser-based multifunctional diagnostics system (LAKK-M) was chosen to carry out non-invasive analysis of multiple parameters. The device was used to simultaneously record the microcirculatory blood flow and oxygen saturation, as well as fluorescence levels of endogenous fluorophores. Preliminary experiments were conducted on adenoviral (Ad-)- mediated overexpression of sFlt-1 (Ad-sFlt-1) to mimic preeclampsialike symptoms in mice. The recorded data displayed the ability of the LAKK-M diagnostics device to detect significant differences in perfusion measurements between the control and Ad-sFlt-1 treatment. Preliminary results provide a potential avenue to employ these diagnostics technology to monitor and aid in maintaining control of live animal conditions throughout the experiment and treatment.
AB - Endothelial dysfunction is directly linked to preeclampsia, a maternal hypertensive condition that is life threating for both the mother and the baby. Epidemiological studies show that women with a history of pre-eclampsia have an elevated risk for cardiovascular disease. Here we report a new non-invasive diagnostic test for preeclampsia in mice that allows us to non-invasively assess the condition of the animals during the experiment and treatment in established models of preeclampsia. A laser-based multifunctional diagnostics system (LAKK-M) was chosen to carry out non-invasive analysis of multiple parameters. The device was used to simultaneously record the microcirculatory blood flow and oxygen saturation, as well as fluorescence levels of endogenous fluorophores. Preliminary experiments were conducted on adenoviral (Ad-)- mediated overexpression of sFlt-1 (Ad-sFlt-1) to mimic preeclampsialike symptoms in mice. The recorded data displayed the ability of the LAKK-M diagnostics device to detect significant differences in perfusion measurements between the control and Ad-sFlt-1 treatment. Preliminary results provide a potential avenue to employ these diagnostics technology to monitor and aid in maintaining control of live animal conditions throughout the experiment and treatment.
U2 - 10.1117/12.2213026
DO - 10.1117/12.2213026
M3 - Other
ER -