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Personal profile

Research Interests

Preeclampsia, a maternal hypertensive condition, is a new risk factor for cardiovascular disease. Key proteins of interest in the disorder are vascular endothelial growth factor and its endogenous antagonist, soluble Flt-1 (sFlt-1). My research activity has focused on understanding their signaling transduction in endothelial cells and placenta. Previously I identified sFlt-1, which is elevated in pregnancies complicated with preeclampsia, as the principal factor responsible for the reduced placental angiogenesis associated with preeclampsia. Ongoing work is aimed at the development of novel in vivo models for preeclampsia and the use of transgenic animals to define how sFlt-1 causes preeclampsia-like condition. Specifically, I am interested in the interaction of these factors with pro-atherogenic chemokines and their role in the disease progression.

Contact Details

Education/Academic qualification

PG Cert

PhD

BSc, University of Kent

Keywords

  • RG Gynecology and obstetrics
  • preeclampsia
  • vascular
  • placenta
  • RB Pathology
  • angiogenesis
  • heme oxygenase

Fingerprint Dive into the research topics where Shakil Ahmad is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 4 Similar Profiles
Vascular Endothelial Growth Factor Receptor-1 Medicine & Life Sciences
Pre-Eclampsia Medicine & Life Sciences
Vascular Endothelial Growth Factor A Medicine & Life Sciences
Endothelial Cells Medicine & Life Sciences
Nitric Oxide Medicine & Life Sciences
Cystathionine Medicine & Life Sciences
Heme Oxygenase-1 Medicine & Life Sciences
Hydrogen Sulfide Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2000 2019

Establishment of porcine and human expanded potential stem cells

Gao, X., Nowak-imialek, M., Chen, X., Chen, D., Herrmann, D., Ruan, D., Chen, A. C. H., Eckersley-maslin, M. A., Ahmad, S., Lee, Y. L., Kobayashi, T., Ryan, D., Zhong, J., Zhu, J., Wu, J., Lan, G., Petkov, S., Yang, J., Antunes, L., Campos, L. S. & 27 others, Fu, B., Wang, S., Yong, Y., Wang, X., Xue, S., Ge, L., Liu, Z., Huang, Y., Nie, T., Li, P., Wu, D., Pei, D., Zhang, Y., Lu, L., Yang, F., Kimber, S. J., Reik, W., Zou, X., Shang, Z., Lai, L., Surani, A., Tam, P. P. L., Ahmed, A., Yeung, W. S. B., Teichmann, S. A., Niemann, H. & Liu, P., 3 Jun 2019, In : Nature Cell Biology. 21, 6, p. 687-699 13 p.

Research output: Contribution to journalArticle

Open Access
File
Swine
Stem Cells
Blastomeres
Germ Layers
Induced Pluripotent Stem Cells

Pravastatin for early‐onset preeclampsia: a randomized, blinded, placebo‐controlled trial

Ahmed, A., Williams, D., Cheed, V., Middleton, L. J., Ahmad, S., Wang, K., Vince, A. T., Hewett, P., Spencer, K., Khan, K. S., Daniels, J. P., Barber, K., Kilby, M., Knox, E., Sellman, T., Trinham, P., Tuffnell, D., Jones, V., Syson, J., Shah, N. & 50 others, Deeks, L., Carter, W., Dorman, E., Thomas, S., Harrington, D., Higgins, N., Wilmott‐powell, M., Simpson, N., Dolby, V., Bricker, L., Walkinshaw, S., Houghton, G., Longworth, H., Williamson, C., Dhanjal, M., Noori, M., Machirori, M., Howard, R., Murray, R., Weist, S., Denison, F., Crawford, I., Robson, S., Allan, C., Myers, J., Bernatavicius, G., Moorhead, L., Chappell, L., Nelson‐piercy, C., Williams, D., Daley, R., Rosas, M., Greer, I., Vitek, L., Shennan, A., Marlow, N., Marie Barnard, A., Thornton, J., Rennie, J., Peacock, J., Gao Smith, F., Hyde, C., Crawford, I., Cudmore, M., Furmston, A., Fulcher, L., Homer, L., Howman, A., Hilken, N. & Brown, S., 12 Nov 2019, In : BJOG.

Research output: Contribution to journalArticle

Open Access
File
Pravastatin
Pre-Eclampsia
Tyrosine
Random Allocation
Placebos

333: Potential preeclampsia therapy tested

Ahmed, A., Wang, K., Ahmad, S. & Rezai, H., 3 Jan 2018, p. S208.

Research output: Contribution to conferencePoster

S100P enhances the motility and invasion of human trophoblast cell lines

Ebrahimzadeh Asl Tabrizi, M., Lancaster, T., Ismail, T. M., Ganguly, A., Georgiadou, A., Wang, K., Rudland, P. S., Ahmad, S. S. & Gross, S. R., 31 Jul 2018, In : Scientific Reports. 8, 11488.

Research output: Contribution to journalArticle

Open Access
File
Trophoblasts
First Pregnancy Trimester
Cell Movement
Physiological Phenomena
Cell Line

Angiopoietin-1 promotes atherosclerosis by increasing the proportion of circulating Gr1+ monocytes

Fujisawa, T., Wang, K., Niu, X-L., Egginton, S., Ahmad, S., Hewett, P. W., Kontos, C. D. & Ahmed, A., 17 Oct 2017, In : Cardiovascular Research. 113, 1, p. 81-89 9 p.

Research output: Contribution to journalArticle

Open Access
File
Angiopoietin-1
Monocytes
Atherosclerosis
Apolipoproteins E
Adenoviridae

Press / Media

Hope in fight against preeclampsia

Shakil Ahmad

12/05/08

1 item of Media coverage

Press/Media: Research