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Personal profile

Research Interests

Preeclampsia, a maternal hypertensive condition, is a new risk factor for cardiovascular disease. Key proteins of interest in the disorder are vascular endothelial growth factor and its endogenous antagonist, soluble Flt-1 (sFlt-1). My research activity has focused on understanding their signaling transduction in endothelial cells and placenta. Previously I identified sFlt-1, which is elevated in pregnancies complicated with preeclampsia, as the principal factor responsible for the reduced placental angiogenesis associated with preeclampsia. Ongoing work is aimed at the development of novel in vivo models for preeclampsia and the use of transgenic animals to define how sFlt-1 causes preeclampsia-like condition. Specifically, I am interested in the interaction of these factors with pro-atherogenic chemokines and their role in the disease progression.

Contact Details

Education/Academic qualification

PG Cert

Award Date: 1 Sep 2017


Award Date: 1 Sep 2005

BSc, University of Kent

Award Date: 1 Sep 1999


  • RG Gynecology and obstetrics
  • preeclampsia
  • vascular
  • placenta
  • RB Pathology
  • angiogenesis
  • heme oxygenase

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Research Output

MZe786 Rescues Cardiac Mitochondrial Activity in High sFlt-1 and Low HO-1 Environment

Sanchez-aranguren, L. C., Rezai, H., Ahmad, S., Alzahrani, F. A., Sparatore, A., Wang, K. & Ahmed, A., 9 Jul 2020, In : Antioxidants. 9, 7, p. 1-16 16 p., 598.

Research output: Contribution to journalArticle

Open Access
  • Pravastatin for early-onset pre-eclampsia: a randomised, blinded, placebo-controlled trial

    Ahmed, A., Williams, D., Cheed, V., Middleton, L. J., Ahmad, S., Wang, K., Vince, A. T., Hewett, P., Spencer, K., Khan, K. S., Daniels, J. P., Barber, K., Kilby, M., Knox, E., Sellman, T., Trinham, P., Tuffnell, D., Jones, V., Syson, J., Shah, N. & 50 others, Deeks, L., Carter, W., Dorman, E., Thomas, S., Harrington, D., Higgins, N., Wilmott‐powell, M., Simpson, N., Dolby, V., Bricker, L., Walkinshaw, S., Houghton, G., Longworth, H., Williamson, C., Dhanjal, M., Noori, M., Machirori, M., Howard, R., Murray, R., Weist, S., Denison, F., Crawford, I., Robson, S., Allan, C., Myers, J., Bernatavicius, G., Moorhead, L., Chappell, L., Nelson‐piercy, C., Williams, D., Daley, R., Rosas, M., Greer, I., Vitek, L., Shennan, A., Marlow, N., Marie Barnard, A., Thornton, J., Rennie, J., Peacock, J., Gao Smith, F., Hyde, C., Crawford, I., Cudmore, M., Furmston, A., Fulcher, L., Homer, L., Howman, A., Hilken, N. & Brown, S., 1 Mar 2020, In : BJOG. 127, 4, p. 478-488 11 p.

    Research output: Contribution to journalArticle

    Open Access
  • Establishment of porcine and human expanded potential stem cells

    Gao, X., Nowak-imialek, M., Chen, X., Chen, D., Herrmann, D., Ruan, D., Chen, A. C. H., Eckersley-maslin, M. A., Ahmad, S., Lee, Y. L., Kobayashi, T., Ryan, D., Zhong, J., Zhu, J., Wu, J., Lan, G., Petkov, S., Yang, J., Antunes, L., Campos, L. S. & 27 others, Fu, B., Wang, S., Yong, Y., Wang, X., Xue, S., Ge, L., Liu, Z., Huang, Y., Nie, T., Li, P., Wu, D., Pei, D., Zhang, Y., Lu, L., Yang, F., Kimber, S. J., Reik, W., Zou, X., Shang, Z., Lai, L., Surani, A., Tam, P. P. L., Ahmed, A., Yeung, W. S. B., Teichmann, S. A., Niemann, H. & Liu, P., 3 Jun 2019, In : Nature Cell Biology. 21, 6, p. 687-699 13 p.

    Research output: Contribution to journalArticle

    Open Access
  • 333: Potential preeclampsia therapy tested

    Ahmed, A., Wang, K., Ahmad, S. & Rezai, H., 3 Jan 2018, p. S208.

    Research output: Contribution to conferencePoster

    S100P enhances the motility and invasion of human trophoblast cell lines

    Ebrahimzadeh Asl Tabrizi, M., Lancaster, T., Ismail, T. M., Ganguly, A., Georgiadou, A., Wang, K., Rudland, P. S., Ahmad, S. S. & Gross, S. R., 31 Jul 2018, In : Scientific Reports. 8, 11488.

    Research output: Contribution to journalArticle

    Open Access
  • Press / Media

    Hope in fight against preeclampsia

    Shakil Ahmad


    1 item of Media coverage

    Press/Media: Research