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Personal profile

General

Dr Wang is a lecturer in Vascular Inflammation and Associate Dean for Research at Aston Medical School. Dr Wang’s postdoctoral research was funded by European Research Council and Medical Research Council. She has extensive research experience in immunology, inflammation and the vascular biology of pregnancy. Her current research interests focus on the role of gaseous transmitters in the pathogenesis of preeclampsia, fetal growth restriction and cardiomyopathy. She discovered hydrogen sulphide (H2S) as an important regulator of the placental vasculature development and showed that a deficiency in its production causes preeclampsia-like features. This study identified H2S as a potential new target for therapeutic intervention against preeclampsia and fetal growth restriction.This work was highlighted as being a “groundbreaking study” by Circulation and within the media (see: Breakthrough in fight against pre-eclampsia).

Research Interests

  • Pathogenesis of preeclampsia - research from basic science to preclinical experimental disease models and paves way to development of novel therapies for preeclampsia.
  • Diagnosis of preeclampsia and fetal growth restriction. Identify novel biomarkers including gaseous molecules, microRNAs and metabolites markers, protein modifications and laser devices.
  • Development of treatment for preeclampsia and fetal growth restriction.
  • Vascular homeostasis and chronic inflammation
  • Cardiomyopathy in pregnancy

Employment

2016 – present     Lecturer, Aston Medical School, Aston University, UK.

2014 – 2016   Aston Academic Research Fellow, Aston University, UK

2012 – 2014   MRC Postdoctoral Research Fellow, Aston University, UK.

2010 – 2012   MRC Postdoctoral Research Fellow, University of Edinburgh, UK. 

2008 – 2010   MRC Postdoctoral Research Fellow, University of Birmingham, UK. 

2002 - 2008    FP6 EU Postdoctoral Research Fellow, University of Birmingham, UK. 

2002               Research Associate, University of Birmingham, UK. 

1993 – 1996   Physician in Capital Pediatric Institution, Beijing, China.

Qualifications

PGCert (2017): Teaching & Learning in Higher Education. Aston University, UK

PhD (2002): Neutrophil spontaneous apoptosis and its regulation by type-I interferon. University of Birmingham, UK.

MSc (1998): Basic mechanism involved in human neutrophil apoptosis and their inhibition in the rheumatoid synovium.University of Birmingham, UK.

MD (1993):   General Medicine. Huazhong University of Science and Technology, China.

Administrative Roles

Assoicated Dean for Research at Aston Medical School since 2017

PhD Supervision

Primary supervisor for 2 PhD students from 2019-2022. 

Associated supervisor for 4 PhD students from 2016.

 

Education/Academic qualification

PG Cert

Award Date: 1 Jan 2017

PhD

Award Date: 1 Aug 2002

MSc

Award Date: 1 Jul 1998

MD

1 Sep 19881 Jul 1993

Award Date: 1 Jul 1993

Keywords

  • RG Gynecology and obstetrics
  • preeclampsia
  • fatal growth restriction
  • gaseous transmitters
  • cardiovascular
  • inflammation

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Research Output

Pravastatin for early-onset pre-eclampsia: a randomised, blinded, placebo-controlled trial

Ahmed, A., Williams, D., Cheed, V., Middleton, L. J., Ahmad, S., Wang, K., Vince, A. T., Hewett, P., Spencer, K., Khan, K. S., Daniels, J. P., Barber, K., Kilby, M., Knox, E., Sellman, T., Trinham, P., Tuffnell, D., Jones, V., Syson, J., Shah, N. & 50 others, Deeks, L., Carter, W., Dorman, E., Thomas, S., Harrington, D., Higgins, N., Wilmott‐powell, M., Simpson, N., Dolby, V., Bricker, L., Walkinshaw, S., Houghton, G., Longworth, H., Williamson, C., Dhanjal, M., Noori, M., Machirori, M., Howard, R., Murray, R., Weist, S., Denison, F., Crawford, I., Robson, S., Allan, C., Myers, J., Bernatavicius, G., Moorhead, L., Chappell, L., Nelson‐piercy, C., Williams, D., Daley, R., Rosas, M., Greer, I., Vitek, L., Shennan, A., Marlow, N., Marie Barnard, A., Thornton, J., Rennie, J., Peacock, J., Gao Smith, F., Hyde, C., Crawford, I., Cudmore, M., Furmston, A., Fulcher, L., Homer, L., Howman, A., Hilken, N. & Brown, S., 12 Nov 2019, In : BJOG.

Research output: Contribution to journalArticle

Open Access
File
  • 333: Potential preeclampsia therapy tested

    Ahmed, A., Wang, K., Ahmad, S. & Rezai, H., 3 Jan 2018, p. S208.

    Research output: Contribution to conferencePoster

    S100P enhances the motility and invasion of human trophoblast cell lines

    Ebrahimzadeh Asl Tabrizi, M., Lancaster, T., Ismail, T. M., Ganguly, A., Georgiadou, A., Wang, K., Rudland, P. S., Ahmad, S. S. & Gross, S. R., 31 Jul 2018, In : Scientific Reports. 8, 11488.

    Research output: Contribution to journalArticle

    Open Access
    File
  • Angiopoietin-1 promotes atherosclerosis by increasing the proportion of circulating Gr1+ monocytes

    Fujisawa, T., Wang, K., Niu, X-L., Egginton, S., Ahmad, S., Hewett, P. W., Kontos, C. D. & Ahmed, A., 17 Oct 2017, In : Cardiovascular Research. 113, 1, p. 81-89 9 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • Heterodimerisation between VEGFR-1 and VEGFR-2 and not the homodimers of VEGFR-1 inhibit VEGFR-2 activity

    Cai, M., Wang, K., Murdoch, C. E., Gu, Y. & Ahmed, A., Jan 2017, In : Vascular Pharmacology. 88, p. 11-20 10 p.

    Research output: Contribution to journalArticle

    Open Access
    File