Disinfection of surgical materials using photo-activated tolonium chloride

Gareth A. Thomson, R. Mackay, Mark S. Pridham, Y.L. Liu

Research output: Chapter in Book/Report/Conference proceedingConference publication

Abstract

Photo-activated disinfection is a technique which has recently become available for use in disinfection in dentistry. This technique makes use of the dye toluidine blue O coupled to a low powered laser to generate singlet oxygen which kills the bacteria without harming the patient. In this paper trials were performed to try to investigate the possibility of the technique for use in other medical applications, particularly related to implants, and orthopedic fixtures. In the trials, samples of stainless steel and polymethylmethacrylate (PMMA) were exposed to Staphylococcus Aureus and Staphylococcus Epidermis bacteria before being treated with a variety of irradiation exposures. Results found that if laser exposure energy exceeded 4.25 J/cm2 then a log reduction of 4 times CFU/cm2 might be expected. Results were similar for both the highly reflective stainless steel and transparent PMMA. Trials were also performed using light emitting diode technology and while these results were less effective, it is felt that the rapid rate of developments in this technology could lead to a cost effective route to rolling photo-activated disinfection out to many more medical applications.

Original languageEnglish
Title of host publicationWorld Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany
Subtitle of host publicationdiagnostic and therapeutic instrumentation, clinical engineering
EditorsOlaf Dössel, Wolfgang C. Schlegel
Place of PublicationBerlin (DE)
PublisherSpringer
Pages133-136
Number of pages4
ISBN (Electronic)978-3-642-03900-3
ISBN (Print)978-3-642-03899-0
DOIs
Publication statusPublished - 1 Dec 2009
EventWorld Congress on Medical Physics and Biomedical Engineering - Munich, Germany
Duration: 7 Sep 200912 Sep 2009

Publication series

NameIFMBE Proceedings
PublisherSpringer
Number10
Volume25
ISSN (Print)1680-0737
ISSN (Electronic)1433-9277

Congress

CongressWorld Congress on Medical Physics and Biomedical Engineering
CountryGermany
CityMunich
Period7/09/0912/09/09
OtherImage Processing, Biosignal Processing, Modelling and Simulation, Biomechanics

Keywords

  • bacteria
  • disinfection
  • laser
  • staphylococcus Aureus
  • staphylococcus Epidermis

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