TY - JOUR
T1 - In-vivo corneal confocal microscopy:
T2 - Imaging analysis, biological insights and future directions
AU - Chiang, Jeremy Chung Bo
AU - Roy, Maitreyee
AU - Kim, Juno
AU - Markoulli, Maria
AU - Krishnan, Arun V.
N1 - Copyright © The Author(s) 2023. This article is licensed under a Creative Commons Attribution 4.0 International License.
PY - 2023/6/19
Y1 - 2023/6/19
N2 - In-vivo corneal confocal microscopy is a powerful imaging technique which provides clinicians and researcher with the capabilities to observe microstructures at the ocular surfaces in significant detail. In this Mini Review, the optics and image analysis methods with the use of corneal confocal microscopy are discussed. While novel insights of neuroanatomy and biology of the eyes, particularly the ocular surface, have been provided by corneal confocal microscopy, some debatable elements observed using this technique remain and these are explored in this Mini Review. Potential improvements in imaging methodology and instrumentation are also suggested.
AB - In-vivo corneal confocal microscopy is a powerful imaging technique which provides clinicians and researcher with the capabilities to observe microstructures at the ocular surfaces in significant detail. In this Mini Review, the optics and image analysis methods with the use of corneal confocal microscopy are discussed. While novel insights of neuroanatomy and biology of the eyes, particularly the ocular surface, have been provided by corneal confocal microscopy, some debatable elements observed using this technique remain and these are explored in this Mini Review. Potential improvements in imaging methodology and instrumentation are also suggested.
UR - https://www.nature.com/articles/s42003-023-05005-8
U2 - 10.1038/s42003-023-05005-8
DO - 10.1038/s42003-023-05005-8
M3 - Review article
C2 - 37336941
SN - 2399-3642
VL - 6
JO - Communications Biology
JF - Communications Biology
IS - 1
M1 - 652
ER -