Solid dispersion – a pragmatic method to improve the bioavailability of poorly soluble drugs

Peng Ke, Sheng Qi, Defang Ouyang, Gabriele Sadowski

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Drugs contained in solid oral dosage forms need to have good solubility in order to result in good bioavailability provided they also have good permeability. Recently, controlled release systems utilize solid dispersion technology to achieve an extended release profile of poorly water-soluble drugs with a short biological half-life. There are two main methods for the preparation of solid dispersions: one is through the use of a liquid phase such as melting and solvent methods, and the other is through a solid phase such as mechanical methods. Ball milling has been widely used to make the amorphous phase. Factors which can affect the physical stability of amorphous solid dispersions have been investigated widely, and glass transition temperatures (Tg), molecular mobility, physical stability of amorphous drugs alone, miscibility between drugs and polymers, and solid solubility of drugs in polymers have been considered as key factors influencing the physical stability of solid dispersions.
Original languageEnglish
Title of host publicationComputational pharmaceutics
Subtitle of host publicationapplication of molecular modeling in drug delivery
EditorsDefang Ouyang, Sean C. Smith
Place of PublicationChichester (UK)
PublisherWiley
Pages81-100
Number of pages20
ISBN (Electronic)978-1-118-57398-3
ISBN (Print)978-1-118-57399-0
DOIs
Publication statusPublished - 29 Jun 2015

Publication series

NameAdvances in Pharmaceutical Technolog
PublisherWiley

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  • Research Output

    Computational pharmaceutics: application of molecular modeling in drug delivery

    Ouyang, D. (ed.) & Smith, S. C. (ed.), 29 Jun 2015, Chichester (UK): Wiley. 340 p. (Advances in Pharmaceutical Technolog)

    Research output: Book/ReportEdited Book

  • Introduction to computational pharmaceutics

    Ouyang, D. & Smith, S. C., 29 Jun 2015, Computational pharmaceutics: application of molecular modeling in drug delivery. Ouyang, D. & Smith, S. C. (eds.). Chichester (UK): Wiley, p. 1-5 5 p. (Advances in Pharmaceutical Technolog).

    Research output: Chapter in Book/Report/Conference proceedingChapter

  • Solubilization of poorly soluble drugs: cyclodextrin-based formulations

    Thakur, S. S., Parekh, H. S., Schwable, C. H., Gan, Y. & Ouyang, D., 29 Jun 2015, Computational pharmaceutics: application of molecular modeling in drug delivery. Ouyang, D. & Smith, S. C. (eds.). Chichester (UK): Wiley, p. 31-51 21 p. (Advances in Pharmaceutical Technolog).

    Research output: Chapter in Book/Report/Conference proceedingChapter

  • Cite this

    Ke, P., Qi, S., Ouyang, D., & Sadowski, G. (2015). Solid dispersion – a pragmatic method to improve the bioavailability of poorly soluble drugs. In D. Ouyang, & S. C. Smith (Eds.), Computational pharmaceutics: application of molecular modeling in drug delivery (pp. 81-100). (Advances in Pharmaceutical Technolog). Wiley. https://doi.org/10.1002/9781118573983.ch5