The biotechnological applications of transglutaminases

Research output: Contribution to journalArticle

Abstract

Transglutaminases catalyse a diverse range of reactions leading to the modification of proteins and peptides such that their physical, chemical and biological properties become changed. They are found in many different living organisms and as a consequence display subtle differences in their biochemical and physical properties. it is therefore not surprising that this group of enzymes have been exploited as applied biocatalysts in a wide range of commercial sectors varying from the textile industry to the highly lucrative cosmetic industry. in addition the pathophysiological importance of this group of enzymes has increased significantly over the last decade with their involvement noted in a number of human diseases. As a consequence their identification as therapeutic targets or as monitoring aids for a range of different diseases has caused significant interest from the diagnostics and pharmaceutical industries. This review describes some of the current applications of transglutaminases; together with their potential strategic importance and future uses.
Original languageEnglish
Pages (from-to)143-148
Number of pages6
JournalMinerva Biotecnologica
Volume14
Issue number2
Publication statusPublished - Jun 2002

Fingerprint

Transglutaminases
Enzymes
Biocatalysts
Cosmetics
Textile industry
Drug products
Peptides
Textile Industry
Industry
Physical properties
Drug Industry
Proteins
Monitoring
Pharmaceutical Preparations
Therapeutics

Keywords

  • transglutaminases
  • proteins
  • peptides
  • enzymes
  • commercial sectors
  • therapeutic
  • monitoring aids
  • diagnostics industry
  • pharmaceutical industry
  • application
  • transglutaminase

Cite this

@article{85f975f467ae46dcbdaf602563361e20,
title = "The biotechnological applications of transglutaminases",
abstract = "Transglutaminases catalyse a diverse range of reactions leading to the modification of proteins and peptides such that their physical, chemical and biological properties become changed. They are found in many different living organisms and as a consequence display subtle differences in their biochemical and physical properties. it is therefore not surprising that this group of enzymes have been exploited as applied biocatalysts in a wide range of commercial sectors varying from the textile industry to the highly lucrative cosmetic industry. in addition the pathophysiological importance of this group of enzymes has increased significantly over the last decade with their involvement noted in a number of human diseases. As a consequence their identification as therapeutic targets or as monitoring aids for a range of different diseases has caused significant interest from the diagnostics and pharmaceutical industries. This review describes some of the current applications of transglutaminases; together with their potential strategic importance and future uses.",
keywords = "transglutaminases, proteins, peptides, enzymes, commercial sectors, therapeutic, monitoring aids, diagnostics industry, pharmaceutical industry, application, transglutaminase",
author = "Russell Collighan and Jo{\~a}o Cortez and Martin Griffin",
year = "2002",
month = "6",
language = "English",
volume = "14",
pages = "143--148",
journal = "Minerva Biotecnologica",
issn = "1120-4826",
publisher = "Edizioni Minerva Medica S.p.A.",
number = "2",

}

The biotechnological applications of transglutaminases. / Collighan, Russell; Cortez, João; Griffin, Martin.

In: Minerva Biotecnologica, Vol. 14, No. 2, 06.2002, p. 143-148.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The biotechnological applications of transglutaminases

AU - Collighan, Russell

AU - Cortez, João

AU - Griffin, Martin

PY - 2002/6

Y1 - 2002/6

N2 - Transglutaminases catalyse a diverse range of reactions leading to the modification of proteins and peptides such that their physical, chemical and biological properties become changed. They are found in many different living organisms and as a consequence display subtle differences in their biochemical and physical properties. it is therefore not surprising that this group of enzymes have been exploited as applied biocatalysts in a wide range of commercial sectors varying from the textile industry to the highly lucrative cosmetic industry. in addition the pathophysiological importance of this group of enzymes has increased significantly over the last decade with their involvement noted in a number of human diseases. As a consequence their identification as therapeutic targets or as monitoring aids for a range of different diseases has caused significant interest from the diagnostics and pharmaceutical industries. This review describes some of the current applications of transglutaminases; together with their potential strategic importance and future uses.

AB - Transglutaminases catalyse a diverse range of reactions leading to the modification of proteins and peptides such that their physical, chemical and biological properties become changed. They are found in many different living organisms and as a consequence display subtle differences in their biochemical and physical properties. it is therefore not surprising that this group of enzymes have been exploited as applied biocatalysts in a wide range of commercial sectors varying from the textile industry to the highly lucrative cosmetic industry. in addition the pathophysiological importance of this group of enzymes has increased significantly over the last decade with their involvement noted in a number of human diseases. As a consequence their identification as therapeutic targets or as monitoring aids for a range of different diseases has caused significant interest from the diagnostics and pharmaceutical industries. This review describes some of the current applications of transglutaminases; together with their potential strategic importance and future uses.

KW - transglutaminases

KW - proteins

KW - peptides

KW - enzymes

KW - commercial sectors

KW - therapeutic

KW - monitoring aids

KW - diagnostics industry

KW - pharmaceutical industry

KW - application

KW - transglutaminase

UR - http://www.minervamedica.it/en/journals/minerva-biotecnologica/index.php

M3 - Article

VL - 14

SP - 143

EP - 148

JO - Minerva Biotecnologica

JF - Minerva Biotecnologica

SN - 1120-4826

IS - 2

ER -