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Personal profile

General

For over thirty years, Professor Griffin's major research area has been geared towards understanding the biochemistry, molecular biology and physiology of a group of enzymes referred to as transglutaminases.  This group of enzymes is commonly referred to as “protein biological glues” since it can crosslink proteins into stable, high molecular weight structures such as those found in skin, in fibrin cross linking during blood coagulation and in hair. 

Focus has been mostly on the tissue transglutaminase (TG2), and in particular, the importance of this enzyme in cell death, matrix deposition and cell adhesion and the relationship of these functions to wound healing, tissue fibrosis and scarring, tumour progression and cystic fibrosis.

Recent work has also been concerned with the use of transglutaminases in the bioengineering of natural polymers for the development of novel biomaterials used in soft (eg: diabetic ulcers and pressure sores) and hard (eg: bone) tissue repair.

Membership of Professional Bodies

  • Panel Member for REF 2014 Unit of Assessment 3
  • President of the European Association for Higher Education in Biotechnology
  • Fellow of the Institute of Biology
  • Evaluator for the National Research Foundation of South Africa
  • EPSRC Peer Review College Member
  • Previous Panel Member of RAE 2008

Qualifications

BSc Applied Biology 1st Class Hons, University of Salford 1970 (4 year sandwich course).

PhD Microbial Biochemistry University College of Wales, Aberystwyth 1974.

Contact Details

Fingerprint Dive into the research topics where Martin Griffin is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 6 Similar Profiles
Transglutaminases Medicine & Life Sciences
Fibronectins Medicine & Life Sciences
Extracellular Matrix Medicine & Life Sciences
Syndecan-4 Medicine & Life Sciences
Celiac Disease Medicine & Life Sciences
transglutaminase 2 Medicine & Life Sciences
Collagen Medicine & Life Sciences
Proteins Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1997 2019

Mapping the minimum domain of the fibronectin binding site on transglutaminase 2 (TG2) and its importance in mediating signaling, adhesion, and migration in TG2-expressing cells

Soluri, M. F., Boccafoschi, F., Cotella, D., Moro, L., Forestieri, G., Autiero, I., Cavallo, L., Oliva, R., Griffin, M., Wang, Z., Santoro, C. & Sblattero, D., 30 Jan 2019, In : FASEB Journal . 33, 2, p. 2327-2342 16 p.

Research output: Contribution to journalArticle

Fibronectins
Adhesion
Binding Sites
Gelatin
Cell Adhesion

Transglutaminase 2 maintains a colorectal cancer stem phenotype by regulating epithelial-mesenchymal transition

Ayinde, O., Wang, Z., Pinton, G., Moro, L. & Griffin, M., 16 Jul 2019, In : Oncotarget. 10, 44, p. 4556-4569 14 p.

Research output: Contribution to journalArticle

Open Access
File
Epithelial-Mesenchymal Transition
Colorectal Neoplasms
Phenotype
Neoplastic Stem Cells
Vascular Endothelial Growth Factor A

Cardiac fibrosis can be attenuated by blocking the activity of transglutaminase 2 using a selective small-molecule inhibitor

Wang, Z., Stuckey, D. J., Murdoch, C. E., Camelliti, P., Lip, G. Y. H. & Griffin, M., 27 Apr 2018, In : Cell Death and Disease. 9, 613.

Research output: Contribution to journalArticle

Open Access
File
Fibrosis
Myofibroblasts
transglutaminase 2
Angiotensin II
Lysine

Involvement of cell surface TG2 in the aggregation of K562 cells triggered by gluten

Feriotto, G., Calza, R., Bergamini, C. M., Griffin, M., Wang, Z., Beninati, S., Ferretti, V., Marzola, E., Guerrini, R., Pagnoni, A., Cavazzini, A., Casciano, F. & Mischiati, C., 1 Mar 2017, In : Amino Acids. 49, 3, p. 551–565

Research output: Contribution to journalArticle

Open Access
File
K562 Cells
Glutens
Agglomeration
Calcium
Guanosine Triphosphate
Open Access
File
Transforming Growth Factors
Endothelial Cells
transglutaminase 2
Myofibroblasts
Coculture Techniques

Thesis

Assessing the physiological and pathological functions of tissue Transglutaminase using FRET analysis

Author: Sharma, S., 12 Feb 2016

Supervisor: Collighan, R. J. (Supervisor) & Griffin, M. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File

Cellular and molecular consequences of S100A4-induced motility in rat breast tumour Rama 37 cells

Author: Sin, C., 22 Nov 2013

Supervisor: Gross, S. R. (Supervisor) & Griffin, M. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File

Characterization of Transglutaminase 2 in macrophage clearance of apoptotic cells

Author: Nadella, V., 16 Dec 2013

Supervisor: Griffin, M. (Supervisor) & Devitt, A. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File

Evaluating transglutaminase crosslinked collagen gel systems for hard and soft tissue repair

Author: Yeh, N., 26 Sep 2013

Supervisor: Collighan, R. J. (Supervisor) & Griffin, M. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File

Isolation, characterisation and application of novel microbial protein cross-linking enzymes

Author: Parsons, R., Dec 2006

Supervisor: Griffin, M. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File

Prizes

Fellow of the Institute of Biology

Martin Griffin (Recipient), 2005

Prize: Election to learned society

biotechnology
president
education

Activities 2010 2012

  • 2 Participation in conference
  • 1 Publication peer-review

Transglutaminases in Human Disease Processes

Martin Griffin (Chair)
19 Jul 2012

Activity: Participating in or organising an event typesParticipation in conference

EMBO Conference on Cellular Signaling & Molecular Medicine

Martin Griffin (Participant)
25 May 201229 May 2012

Activity: Participating in or organising an event typesParticipation in conference

REF 2014 (Event)

Martin Griffin (Peer reviewer)
20102013

Activity: Publication peer-review and editorial work typesPublication peer-review