19972019

Research output per year

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Personal profile

General

For over thirty years, Professor Griffin's major research area has been geared towards understanding the biochemistry, molecular biology and physiology of a group of enzymes referred to as transglutaminases.  This group of enzymes is commonly referred to as “protein biological glues” since it can crosslink proteins into stable, high molecular weight structures such as those found in skin, in fibrin cross linking during blood coagulation and in hair. 

Focus has been mostly on the tissue transglutaminase (TG2), and in particular, the importance of this enzyme in cell death, matrix deposition and cell adhesion and the relationship of these functions to wound healing, tissue fibrosis and scarring, tumour progression and cystic fibrosis.

Recent work has also been concerned with the use of transglutaminases in the bioengineering of natural polymers for the development of novel biomaterials used in soft (eg: diabetic ulcers and pressure sores) and hard (eg: bone) tissue repair.

Membership of Professional Bodies

  • Panel Member for REF 2014 Unit of Assessment 3
  • President of the European Association for Higher Education in Biotechnology
  • Fellow of the Institute of Biology
  • Evaluator for the National Research Foundation of South Africa
  • EPSRC Peer Review College Member
  • Previous Panel Member of RAE 2008

Qualifications

BSc Applied Biology 1st Class Hons, University of Salford 1970 (4 year sandwich course).

PhD Microbial Biochemistry University College of Wales, Aberystwyth 1974.

Contact Details

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Research Output

Mapping the minimum domain of the fibronectin binding site on transglutaminase 2 (TG2) and its importance in mediating signaling, adhesion, and migration in TG2-expressing cells

Soluri, M. F., Boccafoschi, F., Cotella, D., Moro, L., Forestieri, G., Autiero, I., Cavallo, L., Oliva, R., Griffin, M., Wang, Z., Santoro, C. & Sblattero, D., 30 Jan 2019, In : FASEB Journal . 33, 2, p. 2327-2342 16 p.

Research output: Contribution to journalArticle

  • Transglutaminase 2 maintains a colorectal cancer stem phenotype by regulating epithelial-mesenchymal transition

    Ayinde, O., Wang, Z., Pinton, G., Moro, L. & Griffin, M., 16 Jul 2019, In : Oncotarget. 10, 44, p. 4556-4569 14 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • Cardiac fibrosis can be attenuated by blocking the activity of transglutaminase 2 using a selective small-molecule inhibitor

    Wang, Z., Stuckey, D. J., Murdoch, C. E., Camelliti, P., Lip, G. Y. H. & Griffin, M., 27 Apr 2018, In : Cell Death and Disease. 9, 613.

    Research output: Contribution to journalArticle

    Open Access
    File
  • Involvement of cell surface TG2 in the aggregation of K562 cells triggered by gluten

    Feriotto, G., Calza, R., Bergamini, C. M., Griffin, M., Wang, Z., Beninati, S., Ferretti, V., Marzola, E., Guerrini, R., Pagnoni, A., Cavazzini, A., Casciano, F. & Mischiati, C., 1 Mar 2017, In : Amino Acids. 49, 3, p. 551–565

    Research output: Contribution to journalArticle

    Open Access
    File
  • Open Access
    File
  • Thesis

    Assessing the physiological and pathological functions of tissue Transglutaminase using FRET analysis

    Author: Sharma, S., 12 Feb 2016

    Supervisor: Collighan, R. J. (Supervisor) & Griffin, M. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

    File

    Cellular and molecular consequences of S100A4-induced motility in rat breast tumour Rama 37 cells

    Author: Sin, C., 22 Nov 2013

    Supervisor: Gross, S. R. (Supervisor) & Griffin, M. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

    File

    Characterization of Transglutaminase 2 in macrophage clearance of apoptotic cells

    Author: Nadella, V., 16 Dec 2013

    Supervisor: Griffin, M. (Supervisor) & Devitt, A. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

    File

    Evaluating transglutaminase crosslinked collagen gel systems for hard and soft tissue repair

    Author: Yeh, N., 26 Sep 2013

    Supervisor: Collighan, R. J. (Supervisor) & Griffin, M. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

    File

    Isolation, characterisation and application of novel microbial protein cross-linking enzymes

    Author: Parsons, R., Dec 2006

    Supervisor: Griffin, M. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

    File

    Prizes

    Fellow of the Institute of Biology

    Martin Griffin (Recipient), 2005

    Prize: Election to learned society

  • Activities

    • 2 Participation in conference
    • 1 Publication peer-review

    Transglutaminases in Human Disease Processes

    Martin Griffin (Chair)
    19 Jul 2012

    Activity: Participating in or organising an event typesParticipation in conference

    EMBO Conference on Cellular Signaling & Molecular Medicine

    Martin Griffin (Participant)
    25 May 201229 May 2012

    Activity: Participating in or organising an event typesParticipation in conference

    REF 2014 (Event)

    Martin Griffin (Peer reviewer)
    20102013

    Activity: Publication peer-review and editorial work typesPublication peer-review