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Personal profile

Research Interests

Our research is focussed on a group of enzymes called transglutaminases. Transglutaminases are found in many different organisms including microbes, plants and mammals. These enzymes are responsible for a variety of post-translational modifications of proteins, in particular cross-linking of proteins into large molecular weight polymers that are more resistant to degradation. In higher organisms such as mammals, this process is important for the stability of skin, hair, blood clots and the extracellular matrix surrounding cells. In spore-forming bacteria, they cross-link spore coat proteins to enhance spore stability to environmental factors such as heat and chemicals, including antibiotics.

We are interested in elucidating the contribution that transglutaminases have to the stability of structures such as spores and/or the cell wall in clinically-relevant bacteria eg Clostridium difficile and Pseudomonas aeruginosa, respectively. This knowledge is important for understanding survival and defence mechanisms and may lead to identification of novel antimicrobial targets.

Employment

2009- Lecturer in Molecular Biology

2004-2009- Research Fellow, School of Life and Health Sciences, Aston University

1999-2004- Research Fellow, School of Biomedical and Natural Sciences, Nottingham Trent University

1996-1999- Higher Scientific Officer, Microbiology department, Veterinary Laboratories Agency (Weybridge)

1992-1995- PhD Molecular biology, Department of Biochemistry, University of Nottingham

1989-1992- BSc (Hons) Biochemistry and biological chemistry, Department of Biochemistry, University of Nottingham

Contact Details

Tel: +44 (0)121 2044035
Email: r.collighan@aston.ac.uk

Education/Academic qualification

PhD, University of Nottingham

BSc, University of Nottingham

Fingerprint Dive into the research topics where Russell Collighan is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 3 Similar Profiles
Transglutaminases Chemical Compounds
Scaffolds Chemical Compounds
Collagen Chemical Compounds
Scaffolds (biology) Engineering & Materials Science
Celiac Disease Medicine & Life Sciences
Salmonella enteritidis Medicine & Life Sciences
Cell adhesion Chemical Compounds
Enzymes Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1995 2017

Porphyromonas gingivalis gingipains cause defective macrophage migration towards apoptotic cells and inhibit phagocytosis of primary apoptotic neutrophils: gingipains, apoptotic cell removal & inflammation

Castro, S. A., Collighan, R., Lambert, P. A., Dias, H. H. K., Chauhan, P., Bland, C. E., Milic, I., Millward, M. R., Cooper, P. R. & Devitt, A., 2 Mar 2017, In : Cell Death and Disease. 8, 3, 8 p., e2644.

Research output: Contribution to journalArticle

Open Access
File
Cytophagocytosis
Porphyromonas gingivalis
Neutrophils
Macrophages
Inflammation

Isopeptidase activity of human transglutaminase 2: disconnection from transamidation and characterization by kinetic parameters

Kiraly, R., Thangaraju, K., Nagy, Z., Collighan, R., Nemes, Z., Griffin, M. & Fésüs, L., Jan 2016, In : Amino Acids. 48, 1, p. 31-40 10 p.

Research output: Contribution to journalArticle

Open Access
File
Kinetic parameters
Human Activities
Mutation
Amines
Physiological Phenomena

Cross-linking of collagen I by tissue transglutaminase provides a promising biomaterial for promoting bone healing

Fortunati, D., Chau, D. Y. S., Wang, Z., Collighan, R. J. & Griffin, M., 31 Jul 2014, In : Amino Acids. 46, 7, p. 1751-1761 11 p.

Research output: Contribution to journalArticle

Biocompatible Materials
Bone
Collagen
Bone and Bones
Osteoblasts
Factor XIIIa
Transglutaminases
Blood Coagulation Factors
Water
Scaffolds
Indwelling Catheters
Catheters
Central Venous Catheters
Equipment and Supplies
Factor XIIIa

Thesis

Assessing the physiological and pathological functions of tissue Transglutaminase using FRET analysis

Author: Sharma, S., 12 Feb 2016

Supervisor: Collighan, R. J. (Supervisor) & Griffin, M. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File

Evaluating transglutaminase crosslinked collagen gel systems for hard and soft tissue repair

Author: Yeh, N., 26 Sep 2013

Supervisor: Collighan, R. J. (Supervisor) & Griffin, M. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File

Novel collagen- based biomaterials for bone regeneration

Author: Choudhery, H., 21 Mar 2019

Supervisor: Collighan, R. J. (Supervisor) & Martin, R. A. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File

Tissue Transglutaminase (TG2) is a potential therapeutic target in the treatment of chemoresistant breast cancer

Author: Rajasekaran, V., 11 Mar 2014

Supervisor: Griffin, M. (Supervisor), Wang, Z. (Supervisor) & Collighan, R. J. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File

Understanding the link between transglutaminase and the induction of fibrosis in cystic fibrosis (CF)

Author: Nyabam, S., 13 Feb 2015

Supervisor: Marshall, L. J. (Supervisor), Griffin, M. (Supervisor) & Collighan, R. J. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File

Activities 2010 2010

  • 1 Participation in conference

Gordon Research Conferences "Transglutaminases in Human Disease Processes"

Russell Collighan (Participant)
18 Jul 201023 Jul 2010

Activity: Participating in or organising an event typesParticipation in conference