Research output per year
Research output per year
Dr
Accepting PhD Students
PhD projects
- Mitochondrial targeting to address age-related conditions. Finding a better strategy for a better quality of life for the elderly.
- 3Rs approaches to validate the safety of novel nanoparticle formulations by modelling human barriers in vitro
- Nanoformulations targeting the mitochondria in in the treatment of epilepsy during pregnancy
I joined Aston Medical School in 2020 as Lecturer in Bioenergetics, following a productive Research Fellowship position awarded the 50th Anniversary Aston Prize Fellowship in 2018 at Aston Medical School.
My research focuses on understanding the role of mitochondria in the generation of energy in physiological and pathological conditions while elucidating mitochondrial molecular pathways and identifying targets for drug intervention in diverse areas of human disease. My passion for understanding metabolic routes linking mitochondrial bioenergetics and oxidative stress began during my PhD studies where I explored these complex concepts in models resembling cardiovascular complications of pregnancy, such as preeclampsia. Today, these interests have expanded to tackle other critical human disorders while understanding the importance of these signaling processes in health.
Having experience in profiling the mitochondrial fingerprint in broad scenarios of cardiovascular and neuronal distress, I am currently exploring the development of formulations targeting intracellular compartments such as the mitochondria and exploring their potential to deliver cargo (drugs/inhibitors) to the mitochondria.
Targeting the mitochondria using nanoparticles:
Investigating the role of cellular bioenergetics and metabolic dynamics in age-related disorders to identify novel molecular targets for therapeutic intervention.
MBChB:
Physiology and Pharmacology
Reproductive System
Metabolism, Endocrinology and Haematology
Student Selected Component - Library-based research studies
Master in Education (Aston University), Birmingham, UK 2023
Ph.D. Biomedical Sciences (Universidad del Valle) Cali, Colombia 2017
Committee Member British Society for Cardiovascular Research, UK
Fellow Higher Education Academy, UK
Scientific Grant Reviews Committees:
Medical Research Council
British Heart Foundation Grants Referee
ColCiencias, Colombia Grants Referee
University of Valle, Cali, Colombia
Pontifical Xaverian University, Bogota, Colombia
External Reviewer:
Journal of Physiology and Biochemistry
PhD, PhD in Biomedical Sciences, Universidad del Valle
4 Feb 2013 → 6 Oct 2017
Award Date: 6 Oct 2017
Research output: Contribution to journal › Review article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Lissette Sanchez Aranguren (Chair)
Activity: Membership types › Membership of committee
Lissette Sanchez Aranguren (Examiner)
Activity: Examination types › Examination