I joined Aston Medical School in 2020 as Lecturer in Bioenergetics, following a productive Research Fellowship position awarded the 50^th Anniversary Aston Prize Fellowship in 2018 at Aston Medical School.

My research focuses in understanding the role of mitochondria in the generation of energy in physiological and pathological conditions while elucidating mitochondrial molecular pathways and identifying targets for potential drug intervention diverse areas of human disease. My passion to understand metabolic routes liking mitochondrial bioenergetics and oxidative stress began during my PhD studies in were I explored these complex concepts in models resembling cardiovascular complications of pregnancy, such as preeclampsia. Today, these interests have expanded to tackle other important human disorders whilst understanding the importance of these signalling processes in health.

Having experience in profiling the mitochondrial fingerprint in broad scenarios of cardiovascular and neuronal distress, I am currently exploring the development of formulations targeting intracellular compartments such as the mitochondria and exploring their potential to deliver cargo (drugs/inhibitors) to the mitochondria.

Investigating the role of cellular bioenergetics and metabolic dynamics in oxidative stress-related disorders to identify novel molecular targets for therapeutic intervention.

• Understanding the role of mitochondrial metabolism in cellular signalling, proliferation and cell growth.
• Studying the effect of drugs in modulating cellular redox signalling, gene expression and metabolic pathways.

MBChB:

Physiology and Pharmacology

Reproductive System

Metabolism, Haematology and endocrinology

Student Selected Component

Master in Education (Aston University), Birmingham, UK 2021 - Present

Ph.D. Biomedical Sciences (Universidad del Valle) Cali, Colombia 2017

Committee Member British Society for Cardiovascular Research, UK

Fellow Higher Education Academy, UK

Scientific Grant Reviews Committees:

British Heart Foundation Grants Referee

ColCiencias, Colombia Grants Referee

University of Valle, Cali, Colombia

Pontifical Xaverian University, Bogota, Colombia

External Reviewer:

Journal of Physiology and Biochemistry

Sir Halley Stuart Small Grant Award, 2020

MIBTP Case Studentship, 2021

MIBTP Studentship, 2021

• Telephone: 01212045052
• Email: l.sanchez-aranguren2@aston.ac.uk
  
• Room Number: MB314E