Lissette Sanchez Aranguren

Dr

    Accepting PhD Students

    PhD projects

    - Development of a novel controlled release formulation for sodium thiosulfate to protect against oxidative stress-induced damage - Novel controlled-released nanoparticle formulations for healthy vascular ageing

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    Personal profile

    Biography

    I joined Aston Medical School in 2020 as Lecturer in Bioenergetics, following a productive Research Fellowship position awarded the 50th Anniversary Aston Prize Fellowship in 2018 at Aston Medical School.

    My research focuses in understanding the role of mitochondria in the generation of energy in physiological and pathological conditions while elucidating mitochondrial molecular pathways and identifying targets for potential drug intervention diverse areas of human disease. My passion to understand metabolic routes liking mitochondrial bioenergetics and oxidative stress began during my PhD studies in were I explored these complex concepts in models resembling cardiovascular complications of pregnancy, such as preeclampsia. Today, these interests have expanded to tackle other important human disorders whilst understanding the importance of these signalling processes in health.

    Having experience in profiling the mitochondrial fingerprint in broad scenarios of cardiovascular and neuronal distress, I am currently exploring the development of formulations targeting intracellular compartments such as the mitochondria and exploring their potential to deliver cargo (drugs/inhibitors) to the mitochondria.

    Research Interests

    Investigating the role of cellular bioenergetics and metabolic dynamics in oxidative stress-related disorders to identify novel molecular targets for therapeutic intervention.

    • Understanding the role of mitochondrial metabolism in cellular signalling, proliferation and cell growth.
    • Studying the effect of drugs in modulating cellular redox signalling, gene expression and metabolic pathways.

    Teaching Activity

    MBChB:

    Physiology and Pharmacology

    Reproductive System

    Metabolism, Haematology and endocrinology

    Student Selected Component

    Qualifications

    Master in Education (Aston University), Birmingham, UK 2021 - Present

    Ph.D. Biomedical Sciences (Universidad del Valle) Cali, Colombia 2017

    Biochemistry and Clinical Laboratory Science (Universidad de Carabobo) Valencia, Venezuela 2009

    Membership of Professional Bodies

    Committee Member British Society for Cardiovascular Research, UK

    Fellow Higher Education Academy, UK

    Professional/editorial offices

    Scientific Grant Reviews Committees:

    British Heart Foundation Grants Referee

    ColCiencias, Colombia Grants Referee

    University of Valle, Cali, Colombia

    Pontifical Xaverian University, Bogota, Colombia

    External Reviewer:

    Journal of Physiology and Biochemistry

    Funding Applications and Awards

    Sir Halley Stuart Small Grant Award, 2020

    MIBTP Case Studentship, 2021

    MIBTP Studentship, 2021

    Contact Details

    • Telephone: 01212045052
    • Email: l.sanchez-aranguren2@aston.ac.uk
    • Room Number: MB314E

    Education/Academic qualification

    PhD, Universidad del Valle

    4 Feb 20136 Oct 2017

    Award Date: 6 Oct 2017

    Keywords

    • QP Physiology
    • Mitochondria
    • oxidative stress
    • RM Therapeutics. Pharmacology
    • Nanomaterials

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