I joined Aston Medical School in 2020 as Lecturer in Bioenergetics, following a productive Research Fellowship position awarded the 50^th Anniversary Aston Prize Fellowship in 2018 at Aston Medical School.

My research focuses on understanding the role of mitochondria in the generation of energy in physiological and pathological conditions while elucidating mitochondrial molecular pathways and identifying targets for drug intervention in diverse areas of human disease. My passion for understanding metabolic routes linking mitochondrial bioenergetics and oxidative stress began during my PhD studies where I explored these complex concepts in models resembling cardiovascular complications of pregnancy, such as preeclampsia. Today, these interests have expanded to tackle other critical human disorders while understanding the importance of these signaling processes in health.

Having experience in profiling the mitochondrial fingerprint in broad scenarios of cardiovascular and neuronal distress, I am currently exploring the development of formulations targeting intracellular compartments such as the mitochondria and exploring their potential to deliver cargo (drugs/inhibitors) to the mitochondria.

Targeting the mitochondria using nanoparticles:

• Design and development of novel formulations targeting the mitochondria
• Safety of formulations - Can we address mitochondrial dysfunction using nanoparticles as delivery systems?

Investigating the role of cellular bioenergetics and metabolic dynamics in age-related disorders to identify novel molecular targets for therapeutic intervention.

• Understanding the role of mitochondrial metabolism in cellular signalling, proliferation and cell growth.
• Studying the effect of drugs in modulating cellular redox signalling, gene expression and metabolic pathways.

MBChB:

Physiology and Pharmacology

Reproductive System

Metabolism, Endocrinology and Haematology

Student Selected Component - Library-based research studies

Master in Education (Aston University), Birmingham, UK 2023

Ph.D. Biomedical Sciences (Universidad del Valle) Cali, Colombia 2017

Committee Member British Society for Cardiovascular Research, UK

Fellow Higher Education Academy, UK

Scientific Grant Reviews Committees:

Medical Research Council

British Heart Foundation Grants Referee

ColCiencias, Colombia Grants Referee

University of Valle, Cali, Colombia

Pontifical Xaverian University, Bogota, Colombia

External Reviewer:

Journal of Physiology and Biochemistry

• BBSRC IAA Award 2023
• Royal Society Grant - Round 2 - 2022
• MIBTP Case Studentship, 2021
• Sir Halley Stuart Small Grant Award, 2020

• Telephone: 01212045052
• Email: l.sanchez-aranguren2@aston.ac.uk
  
• Room Number: MB314E