Research output per year
Research output per year
Personal profile
Biography
I joined Aston Medical School in 2020 as Lecturer in Bioenergetics, following a productive Research Fellowship position awarded the 50th Anniversary Aston Prize Fellowship in 2018 at Aston Medical School.
My research focuses in understanding the role of mitochondria in the generation of energy in physiological and pathological conditions while elucidating mitochondrial molecular pathways and identifying targets for potential drug intervention diverse areas of human disease. My passion to understand metabolic routes liking mitochondrial bioenergetics and oxidative stress began during my PhD studies in were I explored these complex concepts in models resembling cardiovascular complications of pregnancy, such as preeclampsia. Today, these interests have expanded to tackle other important human disorders whilst understanding the importance of these signalling processes in health.
Having experience in profiling the mitochondrial fingerprint in broad scenarios of cardiovascular and neuronal distress, I am currently exploring the development of formulations targeting intracellular compartments such as the mitochondria and exploring their potential to deliver cargo (drugs/inhibitors) to the mitochondria.
Research Interests
Investigating the role of cellular bioenergetics and metabolic dynamics in oxidative stress-related disorders to identify novel molecular targets for therapeutic intervention.
- Understanding the role of mitochondrial metabolism in cellular signalling, proliferation and cell growth.
- Studying the effect of drugs in modulating cellular redox signalling, gene expression and metabolic pathways.
Teaching Activity
MBChB:
Physiology and Pharmacology
Reproductive System
Metabolism, Haematology and endocrinology
Student Selected Component
Qualifications
Master in Education (Aston University), Birmingham, UK 2021 - Present
Ph.D. Biomedical Sciences (Universidad del Valle) Cali, Colombia 2017
Biochemistry and Clinical Laboratory Science (Universidad de Carabobo) Valencia, Venezuela 2009
Membership of Professional Bodies
Committee Member British Society for Cardiovascular Research, UK
Fellow Higher Education Academy, UK
Professional/editorial offices
Scientific Grant Reviews Committees:
British Heart Foundation Grants Referee
ColCiencias, Colombia Grants Referee
University of Valle, Cali, Colombia
Pontifical Xaverian University, Bogota, Colombia
External Reviewer:
Journal of Physiology and Biochemistry
Funding Applications and Awards
Sir Halley Stuart Small Grant Award, 2020
MIBTP Case Studentship, 2021
MIBTP Studentship, 2021
Contact Details
Education/Academic qualification
PhD, Universidad del Valle
4 Feb 2013 → 6 Oct 2017
Award Date: 6 Oct 2017
Keywords
- QP Physiology
- Mitochondria
- oxidative stress
- RM Therapeutics. Pharmacology
- Nanomaterials
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Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Novel controlled-release polylactic-co-glycolic acid (PLGA) nanoparticles for sodium thiosulphate, a hydrogen sulphide donor, retains pro-angiogenic potential of hydrogen sulphide
Marwah, M. K., Shehzad, S., Shokr, H., Sacharczuk, J., Wang, K., Ahmad, S. & Sanchez-Aranguren, L., 31 Dec 2022, In: Journal of Experimental Nanoscience. 17, 1, p. 197-213 17 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Transdermal Delivery of a Hydrogen Sulphide Donor, ADT-OH Using Aqueous Gel Formulations for the Treatment of Impaired Vascular Function: an Ex Vivo Study
Marwah, M., Shokr, H., Sanchez Aranguren, L., Badhan, R. K. S., Wang, K. & Ahmad, S., Feb 2022, In: Pharmaceutical Research . 39, 2, p. 341-352 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Bioenergetics adaptations and redox homeostasis in pregnancy and related disorders
Sanchez Aranguren, L. & Nadeem, S., Nov 2021, In: Molecular and Cellular Biochemistry. 476, 11, p. 4003–4018 16 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile -
Cholesterol and oxysterol sulfates: Pathophysiological roles and analytical challenges
Diaz Sanchez, L., Pontini, L., Marinozzi, M., Sanchez Aranguren, L., Reis, A. & Dias, I., Aug 2021, In: British Journal of Pharmacology. 178, 16, p. 3327-3341 15 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile -
MZe786, a hydrogen sulfide-releasing aspirin prevents preeclampsia in heme oxygenase-1 haplodeficient pregnancy under high soluble flt-1 environment
Rezai, H., Ahmad, S., Alzahrani, F. A., Sanchez-Aranguren, L., Dias, I. HK., Agrawal, S., Sparatore, A., Wang, K. & Ahmed, A., Jan 2021, In: Redox Biology. 38, 101768.Research output: Contribution to journal › Article › peer-review
Open AccessFile
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The British Society for Cardiovascular Research (External organisation)
Lissette Sanchez Aranguren (Chair)
2022 → 2024Activity: Membership types › Membership of committee
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External examiner
Lissette Sanchez Aranguren (Examiner)
2021 → …Activity: Examination types › Examination