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Research Output 2010 2019

2019

Pravastatin for early-onset pre-eclampsia: a randomised, blinded, placebo-controlled trial

Ahmed, A., Williams, D., Cheed, V., Middleton, L. J., Ahmad, S., Wang, K., Vince, A. T., Hewett, P., Spencer, K., Khan, K. S., Daniels, J. P., Barber, K., Kilby, M., Knox, E., Sellman, T., Trinham, P., Tuffnell, D., Jones, V., Syson, J., Shah, N. & 50 others, Deeks, L., Carter, W., Dorman, E., Thomas, S., Harrington, D., Higgins, N., Wilmott‐powell, M., Simpson, N., Dolby, V., Bricker, L., Walkinshaw, S., Houghton, G., Longworth, H., Williamson, C., Dhanjal, M., Noori, M., Machirori, M., Howard, R., Murray, R., Weist, S., Denison, F., Crawford, I., Robson, S., Allan, C., Myers, J., Bernatavicius, G., Moorhead, L., Chappell, L., Nelson‐piercy, C., Williams, D., Daley, R., Rosas, M., Greer, I., Vitek, L., Shennan, A., Marlow, N., Marie Barnard, A., Thornton, J., Rennie, J., Peacock, J., Gao Smith, F., Hyde, C., Crawford, I., Cudmore, M., Furmston, A., Fulcher, L., Homer, L., Howman, A., Hilken, N. & Brown, S., 12 Nov 2019, In : BJOG.

Research output: Contribution to journalArticle

Open Access
File
Pravastatin
Vascular Endothelial Growth Factor Receptor-1
Pre-Eclampsia
Placebos
Random Allocation
2018

333: Potential preeclampsia therapy tested

Ahmed, A., Wang, K., Ahmad, S. & Rezai, H., 3 Jan 2018, p. S208.

Research output: Contribution to conferencePoster

S100P enhances the motility and invasion of human trophoblast cell lines

Ebrahimzadeh Asl Tabrizi, M., Lancaster, T., Ismail, T. M., Ganguly, A., Georgiadou, A., Wang, K., Rudland, P. S., Ahmad, S. S. & Gross, S. R., 31 Jul 2018, In : Scientific Reports. 8, 11488.

Research output: Contribution to journalArticle

Open Access
File
Trophoblasts
First Pregnancy Trimester
Cell Movement
Physiological Phenomena
Cell Line
2017

Angiopoietin-1 promotes atherosclerosis by increasing the proportion of circulating Gr1+ monocytes

Fujisawa, T., Wang, K., Niu, X-L., Egginton, S., Ahmad, S., Hewett, P. W., Kontos, C. D. & Ahmed, A., 17 Oct 2017, In : Cardiovascular Research. 113, 1, p. 81-89 9 p.

Research output: Contribution to journalArticle

Open Access
File
Angiopoietin-1
Monocytes
Atherosclerosis
Apolipoproteins E
Adenoviridae

Heterodimerisation between VEGFR-1 and VEGFR-2 and not the homodimers of VEGFR-1 inhibit VEGFR-2 activity

Cai, M., Wang, K., Murdoch, C. E., Gu, Y. & Ahmed, A., Jan 2017, In : Vascular Pharmacology. 88, p. 11-20 10 p.

Research output: Contribution to journalArticle

Open Access
File
Vascular Endothelial Growth Factor Receptor-1
Vascular Endothelial Growth Factor Receptor-2
Phosphatidylinositol 3-Kinase
Vascular Endothelial Growth Factor A
Phosphorylation
2016

A pilot study using laser-based technique for non-invasive diagnostics of hypertensive conditions in mice

Choi, B. (ed.), Kollias, N. (ed.), Zeng, H. (ed.), Kang, H. W. (ed.), Wong, B. J. F. (ed.), Ilgner, J. F. (ed.), Tearney, G. J. (ed.), Gregory, K. W. (ed.), Marcu, L. (ed.), Skala, M. C. (ed.), Campagnola, P. J. (ed.), Mandelis, A. (ed.), Morris, M. D. (ed.), Litvinova, K. S., Ahmad, S., Wang, K., Rafailov, I. E., Sokolovski, S. G., Zhang, L., Rafailov, E. U. & 1 others, Ahmed, A., 29 Feb 2016.

Research output: Contribution to conferenceOther

Open Access
File
Pre-Eclampsia
Lasers
Mothers
Equipment and Supplies
Aptitude
2015

Carbon monoxide inhibits sprouting angiogenesis and vascular endothelial growth factor receptor-2 phosphorylation

Ahmad, S., Hewett, P. W., Fujisawa, T., Sissaoui, S., Cai, M., Gueron, G., Al-Ani, B., Cudmore, M., Ahmed, S. F., Wong, M. K. K., Wegiel, B., Otterbein, L. E., Vítek, L., Ramma, W., Wang, K. & Ahmed, A., 1 Feb 2015, In : Thrombosis and Haemostasis. 113, 2, p. 329-337 9 p.

Research output: Contribution to journalArticle

Vascular Endothelial Growth Factor Receptor-2
Carbon Monoxide
Phosphorylation
Fibroblast Growth Factor 2
Vascular Endothelial Growth Factor A

Drug repurposing screen identifies Foxo1-dependent angiopoietin-2 regulation in sepsis

Ghosh, C. C., Thamm, K., Berghelli, A. V., Schrimpf, C., Maski, M. R., Abid, T., Milam, K. E., Rajakumar, A., Santel, A., Kielstein, J. T., Ahmed, A., Thickett, D., Wang, K., Chase, M., Donnino, M. W., Aird, W. C., Haller, H., David, S. & Parikh, S. M., Jul 2015, In : Critical Care Medicine. 43, 7, p. e230-e240 11 p.

Research output: Contribution to journalArticle

Open Access
File
Drug Repositioning
Angiopoietin-2
Sepsis
Simvastatin
Hydroxymethylglutaryl-CoA Reductase Inhibitors

Dysregulation of placental cystathionine-β-synthase impact on fetal growth restriction

Wang, K., Cai, M., Ahmad, S. & Ahmed, A., 13 Mar 2015, In : Reproductive Sciences. 22, Suppl.1, p. A195 1 p., T-276.

Research output: Contribution to journalMeeting abstract

Cystathionine
Fetal Development
Aminooxyacetic Acid
First Pregnancy Trimester
Pre-Eclampsia

Dysregulation of placental cystathionine-β-synthase promotes fetal growth restriction

Wang, K., Cai, M., Abu-Alkheir, W., Ahmad, S. & Ahmed, A., 1 May 2015, In : Nitric Oxide. 47, Suppl.1, p. S57-S58 2 p., PP108.

Research output: Contribution to journalMeeting abstract

Cystathionine
Fetal Development
Pre-Eclampsia
Aminooxyacetic Acid
Lyases

Hydrogen sulphide rescues preeclampsia-like phenotype aggravated by high sFlt-1 in placenta growth factor (PlGF) deficiency

Ahmad, S., Wang, K., Egginton, S., Hewett, P. W. & Ahmed, A., 1 May 2015, In : Nitric Oxide. 47, Suppl.1, p. S27-S28 2 p., PP36.

Research output: Contribution to journalMeeting abstract

Hydrogen Sulfide
Pre-Eclampsia
Intercellular Signaling Peptides and Proteins
Phenotype
Blood pressure

Hydrogen sulphide rescues preeclampsia-like phenotype aggravated by high sFlt-1 in Placenta Growth Factor (PlGF) deficiency

Ahmad, S., Ma, B., Wang, K., Hewett, P., Egginton, S. & Ahmed, A., 13 Mar 2015, In : Reproductive Sciences. 22, Suppl.1, p. A94 1 p., O-117.

Research output: Contribution to journalMeeting abstract

Hydrogen Sulfide
Pre-Eclampsia
Phenotype
Fetal Resorption
Arterial Pressure

Preeclampsia : an accelerator–brake defect disorder

Ahmed, A., Ahmad, S. & Wang, K., 1 May 2015, In : Nitric Oxide. 47, Suppl.1, p. S9 1 p., OP14.

Research output: Contribution to journalArticle

Pre-Eclampsia
Vascular Endothelial Growth Factor A
Hydrogen Sulfide
Carbon Monoxide
Defects
2014

Response to letter regarding article, "Dysregulation of hydrogen sulfide (H2S) producing enzyme cystathionine γ-lyase (CSE) contributes to maternal hypertension and placental abnormalities in preeclampsia"

Wang, K., Ahmad, S., Cai, M., Rennie, J., Fujisawa, T., Crispi, F., Baily, J., Miller, M. R., Cudmore, M., Hadoke, P. W. F., Wang, R., Gratacós, E., Buhimschi, I. A., Buhimschi, C. S. & Ahmed, A., 3 Jun 2014, In : Circulation. 129, 22, p. e517-e518 2 p.

Research output: Contribution to journalArticle

Up-regulation of anti-apoptotic genes confers resistance to the novel anti-leukaemic compound PEP005 in primary AML cells

Hampson, P., Wang, K., Ersvær, E., Mccormack, E., Schüler, J., Fiebig, H., Gjertsen, B. T., Bruserud, Ø. & Lord, J. M., 6 Aug 2014, In : Oncoscience. 1, 8, p. 529-539

Research output: Contribution to journalArticle

Open Access
File
Myeloid Cells
Acute Myeloid Leukemia
Up-Regulation
Genes
Microarray Analysis
2013

Dysregulation of hydrogen sulfide producing enzyme cystathionine γ-lyase contributes to maternal hypertension and placental abnormalities in preeclampsia

Wang, K., Ahmad, S., Cai, M., Rennie, J., Fujisawa, T., Crispi, F., Baily, J., Miller, M. R., Cudmore, M., Hadoke, P. W. F., Wang, R., Gratacós, E., Buhimschi, I. A., Buhimschi, C. S. & Ahmed, A., 25 Jun 2013, In : Circulation. 127, 25, p. 2514-2522 9 p.

Research output: Contribution to journalArticle

Cystathionine
Hydrogen Sulfide
Lyases
Pre-Eclampsia
Mothers
2012

Cyclin-dependent kinase 9 activity regulates neutrophil spontaneous apoptosis

Wang, K., Hampson, P., Hazeldine, J., Krystof, V., Strnad, M., Pechan, P. & Lord, J. M., 19 Jan 2012, In : PLoS ONE. 7, 1, 6 p., e30128.

Research output: Contribution to journalArticle

Open Access
File
Cyclin-Dependent Kinase 9
cyclin-dependent kinase
neutrophils
Neutrophils
apoptosis

Infection with Anaplasma phagocytophilum activates the phosphatidylinositol 3-Kinase/Akt and NF-κB survival pathways in neutrophil granulocytes

Sarkar, A., Hellberg, L., Bhattacharyya, A., Behnen, M., Wang, K., Lord, J. M., Möller, S., Kohler, M., Solbach, W. & Laskay, T., Apr 2012, In : Infection and Immunity. 80, 4, p. 1615-1623 9 p.

Research output: Contribution to journalArticle

Anaplasma phagocytophilum
Phosphatidylinositol 3-Kinase
Granulocytes
Neutrophils
Infection

Loss of Akt activity increases circulating soluble endoglin release in preeclampsia: identification of inter-dependency between Akt-1 and heme oxygenase-1

Cudmore, M. J., Ahmad, S., Sissaoui, S., Ramma, W., Ma, B., Fujisawa, T., Al-Ani, B., Wang, K., Cai, M., Crispi, F., Hewett, P. W., Gratacós, E., Egginton, S. & Ahmed, A., May 2012, In : European Heart Journal. 33, 9, p. 1150-1158 9 p.

Research output: Contribution to journalArticle

Open Access
File
Heme Oxygenase-1
Pre-Eclampsia
1-Phosphatidylinositol 4-Kinase
Fibroblast Growth Factor 2
Phosphoric Monoester Hydrolases
2010

Angiopoietin-1 induces migration of monocytes in a tie-2 and integrin-independent manner

Ahmad, S., Cudmore, M. J., Wang, K., Hewett, P. W., Potluri, R., Fujisawa, T. & Ahmed, A., Sep 2010, In : Hypertension. 56, 3, p. 477-483 7 p.

Research output: Contribution to journalArticle

Angiopoietin-1
Integrins
Monocytes
Umbilicus
1-Phosphatidylinositol 4-Kinase

Dehdyroepiandrosterone sulfate directly activates protein kinase C-β to increase human neutrophil superoxide generation

Radford, D. J., Wang, K., McNelis, J. C., Taylor, A. E., Hechenberger, G., Hofmann, J., Chahal, H., Arlt, W. & Lord, J. M., 1 Apr 2010, In : Molecular Endocrinology. 24, 4, p. 813-821 9 p.

Research output: Contribution to journalArticle

Open Access
Dehydroepiandrosterone Sulfate
Superoxides
Protein Kinase C
Sulfates
Neutrophils