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Research Output

2020

Pravastatin for early-onset pre-eclampsia: a randomised, blinded, placebo-controlled trial

Ahmed, A., Williams, D., Cheed, V., Middleton, L. J., Ahmad, S., Wang, K., Vince, A. T., Hewett, P., Spencer, K., Khan, K. S., Daniels, J. P., Barber, K., Kilby, M., Knox, E., Sellman, T., Trinham, P., Tuffnell, D., Jones, V., Syson, J., Shah, N. & 50 others, Deeks, L., Carter, W., Dorman, E., Thomas, S., Harrington, D., Higgins, N., Wilmott‐powell, M., Simpson, N., Dolby, V., Bricker, L., Walkinshaw, S., Houghton, G., Longworth, H., Williamson, C., Dhanjal, M., Noori, M., Machirori, M., Howard, R., Murray, R., Weist, S., Denison, F., Crawford, I., Robson, S., Allan, C., Myers, J., Bernatavicius, G., Moorhead, L., Chappell, L., Nelson‐piercy, C., Williams, D., Daley, R., Rosas, M., Greer, I., Vitek, L., Shennan, A., Marlow, N., Marie Barnard, A., Thornton, J., Rennie, J., Peacock, J., Gao Smith, F., Hyde, C., Crawford, I., Cudmore, M., Furmston, A., Fulcher, L., Homer, L., Howman, A., Hilken, N. & Brown, S., 1 Mar 2020, In : BJOG. 127, 4, p. 478-488 11 p.

Research output: Contribution to journalArticle

Open Access
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2018

333: Potential preeclampsia therapy tested

Ahmed, A., Wang, K., Ahmad, S. & Rezai, H., 3 Jan 2018, p. S208.

Research output: Contribution to conferencePoster

S100P enhances the motility and invasion of human trophoblast cell lines

Ebrahimzadeh Asl Tabrizi, M., Lancaster, T., Ismail, T. M., Ganguly, A., Georgiadou, A., Wang, K., Rudland, P. S., Ahmad, S. S. & Gross, S. R., 31 Jul 2018, In : Scientific Reports. 8, 11488.

Research output: Contribution to journalArticle

Open Access
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2017

Angiopoietin-1 promotes atherosclerosis by increasing the proportion of circulating Gr1+ monocytes

Fujisawa, T., Wang, K., Niu, X-L., Egginton, S., Ahmad, S., Hewett, P. W., Kontos, C. D. & Ahmed, A., 17 Oct 2017, In : Cardiovascular Research. 113, 1, p. 81-89 9 p.

Research output: Contribution to journalArticle

Open Access
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Heterodimerisation between VEGFR-1 and VEGFR-2 and not the homodimers of VEGFR-1 inhibit VEGFR-2 activity

Cai, M., Wang, K., Murdoch, C. E., Gu, Y. & Ahmed, A., Jan 2017, In : Vascular Pharmacology. 88, p. 11-20 10 p.

Research output: Contribution to journalArticle

Open Access
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2016

A pilot study using laser-based technique for non-invasive diagnostics of hypertensive conditions in mice

Choi, B. (ed.), Kollias, N. (ed.), Zeng, H. (ed.), Kang, H. W. (ed.), Wong, B. J. F. (ed.), Ilgner, J. F. (ed.), Tearney, G. J. (ed.), Gregory, K. W. (ed.), Marcu, L. (ed.), Skala, M. C. (ed.), Campagnola, P. J. (ed.), Mandelis, A. (ed.), Morris, M. D. (ed.), Litvinova, K. S., Ahmad, S., Wang, K., Rafailov, I. E., Sokolovski, S. G., Zhang, L., Rafailov, E. U. & 1 others, Ahmed, A., 29 Feb 2016.

Research output: Contribution to conferenceOther

Open Access
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2015

Carbon monoxide inhibits sprouting angiogenesis and vascular endothelial growth factor receptor-2 phosphorylation

Ahmad, S., Hewett, P. W., Fujisawa, T., Sissaoui, S., Cai, M., Gueron, G., Al-Ani, B., Cudmore, M., Ahmed, S. F., Wong, M. K. K., Wegiel, B., Otterbein, L. E., Vítek, L., Ramma, W., Wang, K. & Ahmed, A., 1 Feb 2015, In : Thrombosis and Haemostasis. 113, 2, p. 329-337 9 p.

Research output: Contribution to journalArticle

Drug repurposing screen identifies Foxo1-dependent angiopoietin-2 regulation in sepsis

Ghosh, C. C., Thamm, K., Berghelli, A. V., Schrimpf, C., Maski, M. R., Abid, T., Milam, K. E., Rajakumar, A., Santel, A., Kielstein, J. T., Ahmed, A., Thickett, D., Wang, K., Chase, M., Donnino, M. W., Aird, W. C., Haller, H., David, S. & Parikh, S. M., Jul 2015, In : Critical Care Medicine. 43, 7, p. e230-e240 11 p.

Research output: Contribution to journalArticle

Open Access
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Dysregulation of placental cystathionine-β-synthase impact on fetal growth restriction

Wang, K., Cai, M., Ahmad, S. & Ahmed, A., 13 Mar 2015, In : Reproductive Sciences. 22, Suppl.1, p. A195 1 p., T-276.

Research output: Contribution to journalMeeting abstract

Dysregulation of placental cystathionine-β-synthase promotes fetal growth restriction

Wang, K., Cai, M., Abu-Alkheir, W., Ahmad, S. & Ahmed, A., 1 May 2015, In : Nitric Oxide. 47, Suppl.1, p. S57-S58 2 p., PP108.

Research output: Contribution to journalMeeting abstract

Hydrogen sulphide rescues preeclampsia-like phenotype aggravated by high sFlt-1 in placenta growth factor (PlGF) deficiency

Ahmad, S., Wang, K., Egginton, S., Hewett, P. W. & Ahmed, A., 1 May 2015, In : Nitric Oxide. 47, Suppl.1, p. S27-S28 2 p., PP36.

Research output: Contribution to journalMeeting abstract

Hydrogen sulphide rescues preeclampsia-like phenotype aggravated by high sFlt-1 in Placenta Growth Factor (PlGF) deficiency

Ahmad, S., Ma, B., Wang, K., Hewett, P., Egginton, S. & Ahmed, A., 13 Mar 2015, In : Reproductive Sciences. 22, Suppl.1, p. A94 1 p., O-117.

Research output: Contribution to journalMeeting abstract

Preeclampsia : an accelerator–brake defect disorder

Ahmed, A., Ahmad, S. & Wang, K., 1 May 2015, In : Nitric Oxide. 47, Suppl.1, p. S9 1 p., OP14.

Research output: Contribution to journalArticle

2014

Response to letter regarding article, "Dysregulation of hydrogen sulfide (H2S) producing enzyme cystathionine γ-lyase (CSE) contributes to maternal hypertension and placental abnormalities in preeclampsia"

Wang, K., Ahmad, S., Cai, M., Rennie, J., Fujisawa, T., Crispi, F., Baily, J., Miller, M. R., Cudmore, M., Hadoke, P. W. F., Wang, R., Gratacós, E., Buhimschi, I. A., Buhimschi, C. S. & Ahmed, A., 3 Jun 2014, In : Circulation. 129, 22, p. e517-e518 2 p.

Research output: Contribution to journalArticle

Up-regulation of anti-apoptotic genes confers resistance to the novel anti-leukaemic compound PEP005 in primary AML cells

Hampson, P., Wang, K., Ersvær, E., Mccormack, E., Schüler, J., Fiebig, H., Gjertsen, B. T., Bruserud, Ø. & Lord, J. M., 6 Aug 2014, In : Oncoscience. 1, 8, p. 529-539

Research output: Contribution to journalArticle

Open Access
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2013

Dysregulation of hydrogen sulfide producing enzyme cystathionine γ-lyase contributes to maternal hypertension and placental abnormalities in preeclampsia

Wang, K., Ahmad, S., Cai, M., Rennie, J., Fujisawa, T., Crispi, F., Baily, J., Miller, M. R., Cudmore, M., Hadoke, P. W. F., Wang, R., Gratacós, E., Buhimschi, I. A., Buhimschi, C. S. & Ahmed, A., 25 Jun 2013, In : Circulation. 127, 25, p. 2514-2522 9 p.

Research output: Contribution to journalArticle

2012

Cyclin-dependent kinase 9 activity regulates neutrophil spontaneous apoptosis

Wang, K., Hampson, P., Hazeldine, J., Krystof, V., Strnad, M., Pechan, P. & Lord, J. M., 19 Jan 2012, In : PLoS ONE. 7, 1, 6 p., e30128.

Research output: Contribution to journalArticle

Open Access
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Infection with Anaplasma phagocytophilum activates the phosphatidylinositol 3-Kinase/Akt and NF-κB survival pathways in neutrophil granulocytes

Sarkar, A., Hellberg, L., Bhattacharyya, A., Behnen, M., Wang, K., Lord, J. M., Möller, S., Kohler, M., Solbach, W. & Laskay, T., Apr 2012, In : Infection and Immunity. 80, 4, p. 1615-1623 9 p.

Research output: Contribution to journalArticle

Loss of Akt activity increases circulating soluble endoglin release in preeclampsia: identification of inter-dependency between Akt-1 and heme oxygenase-1

Cudmore, M. J., Ahmad, S., Sissaoui, S., Ramma, W., Ma, B., Fujisawa, T., Al-Ani, B., Wang, K., Cai, M., Crispi, F., Hewett, P. W., Gratacós, E., Egginton, S. & Ahmed, A., May 2012, In : European Heart Journal. 33, 9, p. 1150-1158 9 p.

Research output: Contribution to journalArticle

Open Access
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2010

Angiopoietin-1 induces migration of monocytes in a tie-2 and integrin-independent manner

Ahmad, S., Cudmore, M. J., Wang, K., Hewett, P. W., Potluri, R., Fujisawa, T. & Ahmed, A., Sep 2010, In : Hypertension. 56, 3, p. 477-483 7 p.

Research output: Contribution to journalArticle

Dehdyroepiandrosterone sulfate directly activates protein kinase C-β to increase human neutrophil superoxide generation

Radford, D. J., Wang, K., McNelis, J. C., Taylor, A. E., Hechenberger, G., Hofmann, J., Chahal, H., Arlt, W. & Lord, J. M., 1 Apr 2010, In : Molecular Endocrinology. 24, 4, p. 813-821 9 p.

Research output: Contribution to journalArticle

Open Access