Dr Alice Rothnie

Alice Rothnie
Postal address:
United Kingdom

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General

I joined Aston School of Life & Health Sciences in Jan 2010, having spent the previous two years as a postdoctoral researcher in Structural Biology at Warwick University, working with Dr. Corinne Smith on the mechanism of clathrin cage disassembly by the chaperone Hsc70.

Prior to this I held a postdoctoral fellowship at the Cancer Research Institute, Queen’s University, Kinston ON, Canada, working with Prof. Susan Cole on the interaction of MRP1 (multidrug resistance protein 1) with GSH.

I completed my PhD in the lab of Dr. Richard Callaghan at the Nuffield Dept. Clinical Lab. Sciences, John Radcliffe Hospital, Oxford, on the topographical changes of TM6 of P-glycoprotein.

Research interests

My research interests lie in elucidating the mechanistic functional details of transmembrane and membrane-associated proteins, that do important jobs in the cell, both in health and disease. To date I have predominantly focused on membrane transporter proteins of the ABC superfamily (ATP Binding Casette), and proteins involved in cellular trafficking, but recently I have expanded this to include secondary active transporters, ion channels and GPCRs (G-protein coupled receptors). By fully understanding exactly how a protein works, we can begin to understand how it goes wrong in disease states and how we might be able to target it therapeutically. To carry out this work I am really keen to develop new methods and techniques that enable us to answer important questions about the target protein, and as such have played a major role in developing the SMALP (styrene maleic acid lipid particle) technology for membrane protein extraction, purification, structural and functional characterization.

Qualifications

  • Postgraduate Certificate in Professional Practice in Higher Education (PGCPP) with Distinction. Aston University, Birmingham. 2012-2013
  • DPhil, in Biochemistry. Nuffield Dept. Clinical Lab. Sciences, University of Oxford. 2000-2004
  • MBiochem honours (2.1), in Biochemistry. Brasenose College, University of Oxford. 1996-2000

Employment

  • Jan 2010 – present: Lecturer in Cell Biology/Biochemistry. Aston University, Birmingham, UK.
  • Sept 2007 – Dec 2009: Post-doctoral researcher, Dept. Biological Sciences, Warwick University, Coventry, UK.
  • May 2004 – Aug 2007: Post-doctoral fellow, Cancer Research Institute, Queen’s University, Kingston ON, Canada. Recipient of a CIHR (Canadian Institutes Health Research) fellowship

Membership of Professional Bodies

  • Fellow of the Higher Education Academy
  • Biochemical Society
  • The Protein Society
  • British Pharmacological Society
  • CBMNet

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Clinical and Systems Neuroscience

Organisational unit: School

  1. 6th Special Meeting on ATP-Binding Cassette Proteins: From Multidrug Resistance to Genetic Disease

    Activity: Participating in or organising an event typesParticipation in conference

  2. Biochemical Journal (Journal)

    Activity: Publication peer-review and editorial work typesPublication peer-review

  3. Biochemical Society Transactions (Journal)

    Activity: Publication peer-review and editorial work typesPublication peer-review

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