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Research Output 2006 2019

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2019

The Parkinson's Disease-Linked Protein DJ-1 Associates with Cytoplasmic mRNP Granules During Stress and Neurodegeneration

Repici, M., Hassanjani, M., Maddison, D. C., Garção, P., Cimini, S., Patel, B., Szegö, É. M., Straatman, K. R., Lilley, K. S., Borsello, T., Outeiro, T. F., Panman, L. & Giorgini, F., 1 Jan 2019, In : Molecular Neurobiology. 56, 1, p. 61-77 17 p.

Research output: Contribution to journalArticle

Open Access
File
Cytoplasmic Granules
Parkinson Disease
Oxidative Stress
RNA
Messenger RNA
2017

Adaptive and Behavioral Changes in Kynurenine 3-Monooxygenase Knockout Mice: Relevance to Psychotic Disorders

Erhardt, S., Pocivavsek, A., Repici, M., Liu, X-C., Imbeault, S., Maddison, D. C., Thomas, M. A. R., Smalley, J. L., Larsson, M. K., Muchowski, P. J., Giorgini, F. & Schwarcz, R., 15 Nov 2017, In : Biological Psychiatry. 82, 10, p. 756-765 10 p.

Research output: Contribution to journalArticle

Open Access
File
Kynurenine 3-Monooxygenase
Knockout Mice
Psychotic Disorders
Kynurenic Acid
Kynurenine
2014

Copy-number variation of the neuronal glucose transporter gene SLC2A3 and age of onset in Huntington's disease

15 Jun 2014, In : Human Molecular Genetics. 23, 12, p. 3129-3137 9 p.

Research output: Contribution to journalArticle

Open Access
File
Facilitative Glucose Transport Proteins
Huntington Disease
Age of Onset
Genes
Trinucleotide Repeat Expansion

DJ-1 interactions with α-synuclein attenuate aggregation and cellular toxicity in models of Parkinson's disease

Zondler, L., Miller-Fleming, L., Repici, M., Gonçalves, S., Tenreiro, S., Rosado-Ramos, R., Betzer, C., Straatman, K. R., Jensen, P. H., Giorgini, F. & Outeiro, T. F., 24 Jul 2014, In : Cell Death and Disease. 5, e1350.

Research output: Contribution to journalArticle

Open Access
File
Synucleins
Parkinson Disease
Mutation
Lewy Bodies
Neurons
2013

Parkinson's disease-associated mutations in DJ-1 modulate its dimerization in living cells

Repici, M., Straatman, K. R., Balduccio, N., Enguita, F. J., Outeiro, T. F. & Giorgini, F., May 2013, In : Journal of Molecular Medicine. 91, 5, p. 599-611 13 p.

Research output: Contribution to journalArticle

Open Access
File
Dimerization
Parkinson Disease
Mutation
Oxidative Stress
Mutant Proteins
2012

Specific inhibition of the JNK pathway promotes locomotor recovery and neuroprotection after mouse spinal cord injury

Repici, M., Chen, X., Morel, M-P., Doulazmi, M., Sclip, A., Cannaya, V., Veglianese, P., Kraftsik, R., Mariani, J., Borsello, T. & Dusart, I., Jun 2012, In : Neurobiology of Disease. 46, 3, p. 710-721 12 p.

Research output: Contribution to journalArticle

MAP Kinase Signaling System
Spinal Cord Injuries
Neuroprotective Agents
Intraperitoneal Injections
Blood-Brain Barrier
2011

c-Jun N-terminal kinase (JNK) and p38 play different roles in age-related Purkinje cell death in murine organotypic culture

Repici, M., Wehrlé, R., Antoniou, X., Borsello, T. & Dusart, I., Jun 2011, In : The Cerebellum. 10, 2, p. 281-290 10 p.

Research output: Contribution to journalArticle

JNK Mitogen-Activated Protein Kinases
Purkinje Cells
Cell Death
MAP Kinase Signaling System
Mitogen-Activated Protein Kinase Kinases
2010

Role of Glycogen Synthase Kinase-3β in APP Hyperphosphorylation Induced by NMDA Stimulation in Cortical Neurons

Ploia, C., Sclip, A., Colombo, A., Repici, M., Gardoni, F., Di Luca, M., Forloni, G., Antoniou, X. & Borsello, T., 7 Jan 2010, In : Pharmaceuticals. 3, 1, p. 42-58 17 p.

Research output: Contribution to journalArticle

Open Access
File
Glycogen Synthase Kinase 3
Amyloid beta-Protein Precursor
N-Methylaspartate
Neurons
Cyclin-Dependent Kinase 5
2009

Age-dependent impairment of spine morphology and synaptic plasticity in hippocampal CA1 neurons of a presenilin 1 transgenic mouse model of Alzheimer's disease

Auffret, A., Gautheron, V., Repici, M., Kraftsik, R., Mount, H. T. J., Mariani, J. & Rovira, C., 12 Aug 2009, In : Journal of Neuroscience. 29, 32, p. 10144-10152 9 p.

Research output: Contribution to journalArticle

Open Access
File
Presenilin-1
Neuronal Plasticity
Transgenic Mice
Alzheimer Disease
Spine
MAP Kinase Kinase 4
MAP Kinase Kinase Kinases
JNK Mitogen-Activated Protein Kinases
Extracellular Signal-Regulated MAP Kinases
Phosphotransferases
2008

Recombinant human TNF-binding protein-1 (rhTBP-1) treatment delays both symptoms progression and motor neuron loss in the wobbler mouse

Bigini, P., Repici, M., Cantarella, G., Fumagalli, E., Barbera, S., Cagnotto, A., De Luigi, A., Tonelli, R., Bernardini, R., Borsello, T. & Mennini, T., Mar 2008, In : Neurobiology of Disease. 29, 3, p. 465-476 12 p.

Research output: Contribution to journalArticle

Motor Neurons
Carrier Proteins
Tumor Necrosis Factor-alpha
Receptors, Tumor Necrosis Factor, Type I
Phosphorylation

Specific JNK inhibition by D-JNKI1 protects Purkinje cells from cell death in Lurcher mutant mouse

Repici, M., Zanjani, H. S., Gautheron, V., Borsello, T., Dusart, I. & Mariani, J., 2008, In : The Cerebellum. 7, 4, p. 534-538 5 p.

Research output: Contribution to journalArticle

Neurologic Mutant Mice
Purkinje Cells
Cell Death
Phosphotransferases
Ionotropic Glutamate Receptors
2007

Time-course of c-Jun N-terminal kinase activation after cerebral ischemia and effect of D-JNKI1 on c-Jun and caspase-3 activation

Repici, M., Centeno, C., Tomasi, S., Forloni, G., Bonny, C., Vercelli, A. & Borsello, T., 30 Nov 2007, In : Neuroscience. 150, 1, p. 40-49 10 p.

Research output: Contribution to journalArticle

JNK Mitogen-Activated Protein Kinases
Brain Ischemia
Caspase 3
Phosphotransferases
MAP Kinase Kinase Kinase 4
2006

Role of the JNK pathway in NMDA-mediated excitotoxicity of cortical neurons

Centeno, C., Repici, M., Chatton, J-Y., Riederer, B. M., Bonny, C., Nicod, P., Price, M., Clarke, P. G. H., Papa, S., Franzoso, G. & Borsello, T., 23 Jun 2006, In : Cell Death and Differentiation. 14, 2, p. 240-253 14 p.

Research output: Contribution to journalArticle

JNK Mitogen-Activated Protein Kinases
N-Methylaspartate
Neurons
MAP Kinase Kinase Kinase 4
MAP Kinase Kinase 7