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Research Output 1997 2019

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Pituitary adenylate cyclase-activating polypeptide type 1 receptor (PAC1) gene is suppressed by transglutaminase 2 activation

Miura, A., Kambe, Y., Inoue, K., Tatsukawa, H., Kurihara, T., Griffin, M., Kojima, S. & Miyata, A., 8 Nov 2013, In : Journal of Biological Chemistry. 288, 45, p. 32720-32730 11 p.

Research output: Contribution to journalArticle

Open Access
File
Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I
Endoplasmic Reticulum Stress
Gene expression
Genes
Chemical activation

Recent advances in the development of tissue transglutaminase (TG2) inhibitors

Badarau, E., Collighan, R. J. & Griffin, M., Jan 2013, In : Amino Acids. 44, 1, p. 119-127 9 p.

Research output: Contribution to journalArticle

Open Access
File
Biological Phenomena
Transglutaminases
Enzyme Activation
Huntington Disease
Celiac Disease
Open Access
File
Syndecan-2
Syndecan-4
Cell adhesion
Fibronectins
Cell Adhesion

Role of transglutaminase 1 in stabilisation of intercellular junctions of the vascular endothelium

Baumgartner, W., Golenhofen, N., Weth, A., Hiiragi, T., Saint, R., Griffin, M. & Drenckhahn, D., Jul 2004, In : Histochemistry and Cell Biology. 122, 1, p. 17-25 9 p.

Research output: Contribution to journalArticle

Intercellular Junctions
Vascular Endothelium
Cytochalasin D
Lung
Endothelial Cells

Synthesis of potent water-soluble tissue transglutaminase inhibitors

Griffin, M., Mongeot, A., Collighan, R., Saint, R. E., Jones, R. A., Coutts, I. G. C. & Rathbone, D. L., 15 Oct 2008, In : Bioorganic and Medicinal Chemistry Letters. 18, 20, p. 5559-5562 4 p.

Research output: Contribution to journalArticle

Diazooxonorleucine
Lead compounds
Transglutaminases
Dipeptides
Water

Tailored laminin-332 alpha3 sequence is tethered through an enzymatic linker to a collagen scaffold to promote cellular adhesion

Damodaran, G., Collighan, R., Griffin, M., Navsaria, H. & Pandit, A. S., Sep 2009, In : Acta Biomaterialia. 5, 7, p. 2441-2450 10 p.

Research output: Contribution to journalArticle

Transglutaminases
Scaffolds (biology)
Collagen
Scaffolds
Peptides
Transglutaminases
Liposomes
Liver Cirrhosis
Liver
Fibrosis

Tethering a laminin peptide to a crosslinked collagen scaffold for biofunctionality

Damodaran, G., Collighan, R., Griffin, M. & Pandit, A., 15 Jun 2009, In : Journal of Biomedical Materials Research: Part A. 89A, 4, p. 1001-1010 10 p.

Research output: Contribution to journalArticle

Laminin
Scaffolds (biology)
Transglutaminases
Collagen
Peptides

TG2, a novel extracellular protein with multiple functions

Wang, Z. & Griffin, M., Feb 2012, In : Amino Acids. 42, 2-3, p. 939-949 11 p.

Research output: Contribution to journalArticle

Syndecan-4
Multifunctional Enzymes
Military electronic countermeasures
Heparan Sulfate Proteoglycans
Proteins

The biotechnological applications of transglutaminases

Collighan, R., Cortez, J. & Griffin, M., Jun 2002, In : Minerva Biotecnologica. 14, 2, p. 143-148 6 p.

Research output: Contribution to journalArticle

Transglutaminases
Enzymes
Biocatalysts
Cosmetics
Textile industry
Fibrosarcoma
Cricetinae
Cell Cycle
Apoptosis
Drug Therapy

The cellular response to transglutaminase-cross-linked collagen

Chau, D. Y. S., Collighan, R., Verderio, E. A. M., Addy, V. L. & Griffin, M., Nov 2005, In : Biomaterials. 26, 33, p. 6518-6529 12 p.

Research output: Contribution to journalArticle

Transglutaminases
Collagen
Osteoblasts
Collagen Type I
Foreskin
Open Access
File
Transforming Growth Factors
Endothelial Cells
transglutaminase 2
Myofibroblasts
Coculture Techniques

Thermodynamics of binding of regulatory ligands to tissue transglutaminase

Bergamini, C. M., Dondi, A., Lanzara, V., Squerzanti, M., Cervellati, C., Montin, K., Mischiati, C., Tasco, G., Collighan, R., Griffin, M. & Casadio, R., 22 Dec 2009, In : Amino Acids. 39, 1, p. 297-304 8 p.

Research output: Contribution to journalArticle

Thermodynamics
Guanosine Triphosphate
Ligands
Calcium
Hot Temperature

The role of TG2 in ECV304-related vasculogenic mimicry

Jones, R. A., Wang, Z., Dookie, S. & Griffin, M., Jan 2013, In : Amino Acids. 44, 1, p. 89-101 13 p.

Research output: Contribution to journalArticle

Tumors
Fibronectins
Cell Line
Neoplasms
Focal Adhesions

The role of TG2 in regulating S100A4-mediated mammary tumour cell migration

Wang, Z. & Griffin, M., 1 Mar 2013, In : PLoS ONE. 8, 3, 16 p., e57017.

Research output: Contribution to journalArticle

Open Access
File
mammary neoplasms (animal)
cell movement
Crosslinking
Cell Movement
Tumors

The role of tissue transglutaminase (TG2) in regulating the tumour progression of the mouse colon carcinoma CT26

Kotsakis, P., Wang, Z., Collighan, R. J. & Griffin, M., Oct 2011, In : Amino Acids. 41, 4, p. 909-921 13 p.

Research output: Contribution to journalArticle

Open Access
File
Fibronectins
Integrins
Tumors
Colon
Carcinoma

The role of tissue transglutaminase in 1-methyl-4-phenylpyridinium (MPP+)-induced toxicity in differentiated human SH-SY5Y neuroblastoma cells

Beck, K. E., De Girolamo, L. A., Griffin, M. & Billett, E. E., 11 Sep 2006, In : Neuroscience Letters. 405, 1-2, p. 46-51 6 p.

Research output: Contribution to journalArticle

Open Access
File
1-Methyl-4-phenylpyridinium
Neuroblastoma
Transglutaminases
Polyamines
Proteins

The role of transglutaminase in the rat subtotal nephrectomy model of renal fibrosis

Johnson, T. S., Griffin, M., Thomas, G. L., Skill, J., Cox, A., Bin Yang, B., Nicholas, B., Birckbichler, P. J., Muchaneta-Kubara, C. & El Nahas, A. M., 15 Jun 1997, In : Journal of Clinical Investigation. 99, 12, p. 2950-2960 11 p.

Research output: Contribution to journalArticle

Open Access
File
Transglutaminases
Nephrectomy
Fibrosis
Kidney
Extracellular Matrix Proteins

The visualisation of vitreous using surface modified poly(lactic-co-glycolic acid) microparticles

Chau, D. Y. S., Tint, N. L., Collighan, R. J., Griffin, M., Dua, H. S., Shakesheff, K. M. & Rose, F. R. A. J., 2010, In : British Journal of Ophthalmology. 94, 5, p. 648-653 6 p.

Research output: Contribution to journalArticle

Open Access
File
Triamcinolone
Suspensions
Transglutaminases
Vitrectomy
Swine

Thioredoxin is involved in endothelial cell extracellular transglutaminase 2 activation mediated by celiac disease patient IgA

Nadalutti, C. A., Korponay-Szabo, I. R., Kaukinen, K., Wang, Z., Griffin, M., Mäki, M. & Lindfors, K., 9 Oct 2013, In : PLoS ONE. 8, 10, 12 p., e77277.

Research output: Contribution to journalArticle

Open Access
File
Thioredoxins
celiac disease
protein-glutamine gamma-glutamyltransferase
Endothelial cells
Celiac Disease

Tissue transglutaminase: a mediator and predictor of chronic allograft nephropathy?

Johnson, T. S., Abo-Zenah, H., Skill, J. N., Bex, S., Wild, G., Brown, C. B., Griffin, M. & El Nahas, A. M., 15 Jun 2004, In : Transplantation. 77, 11, p. 1667-1675 9 p.

Research output: Contribution to journalArticle

Allografts
Kidney
Biopsy
Fibrosis
Staining and Labeling

Tissue transglutaminase (TG2) - a wound response enzyme

Telci, D. & Griffin, M., 1 Jan 2006, In : Frontiers in Bioscience. 11, 1, p. 867-882 16 p.

Research output: Contribution to journalArticle

Wound Healing
Repair
Extracellular Matrix
Transglutaminases
Wounds and Injuries

Tissue transglutaminase (TG2) enables survival of human malignant pleural mesothelioma cells in hypoxia

Zonca, S., Pinton, G., Wang, Z., Soluri, M. F., Tavian, D., Griffin, M., Sblattero, D. & Moro, L., 2 Feb 2017, In : Cell Death and Disease. 8, 2, 7 p., e2592.

Research output: Contribution to journalArticle

Open Access
File
Cell Hypoxia
Survival
Cell Survival
Epithelioid Cells
Malignant Mesothelioma

Tissue transglutaminase and the progression of human renal scarring

Johnson, T. S., El-Koraie, A. F., Skill, N. J., Baddour, N. M., El Nahas, A. M., Njloma, M., Adam, A. G. & Griffin, M., 1 Aug 2003, In : Journal of the American Society of Nephrology. 14, 8, p. 2052-2062 11 p.

Research output: Contribution to journalArticle

Cicatrix
Kidney
Chronic Renal Insufficiency
Lysine
Extracellular Matrix

Tissue transglutaminase and the stress response

Ientile, R., Caccamo, D. & Griffin, M., Aug 2007, In : Amino Acids. 33, 2, p. 385-394 10 p.

Research output: Contribution to journalArticle

Transglutaminases
Enzymes
Oxidative stress
Cross Reactions
Cell death

Tissue transglutaminase induces epithelial-mesenchymal-transition and the acquisition of stem cell like characteristics in colorectal cancer cells

Ayinde, O., Wang, Z. & Griffin, M., 16 Feb 2017, In : Oncotarget. 8, 12, p. 20025-20041 17 p.

Research output: Contribution to journalArticle

Open Access
File
Catenins
Epithelial-Mesenchymal Transition
Colorectal Neoplasms
Stem Cells
Cell Line

Tissue transglutaminase in tumour progression: Friend or foe?

Kotsakis, P. & Griffin, M., Aug 2007, In : Amino Acids. 33, 2, p. 373-384 12 p.

Research output: Contribution to journalArticle

Tumors
Neoplasms
Military electronic countermeasures
Biological Phenomena
transglutaminase 2

Towards development of a dermal rudiment for enhanced wound healing response

Garcia, Y., Wilkins, B., Collighan, R., Griffin, M. & Pandit, A. S., Mar 2008, In : Biomaterials. 29, 7, p. 857-868 12 p.

Research output: Contribution to journalArticle

Collagen
Scaffolds
Wound Healing
Re-Epithelialization
Transglutaminases

Transglutaminase 2 cross-linking of matrix proteins: biological significance and medical applications

Collighan, R. & Griffin, M., Apr 2009, In : Amino Acids. 36, 4, p. 659-670 12 p.

Research output: Contribution to journalArticle

Medical applications
Transglutaminases
Cell adhesion
Biocompatible Materials
Pathology

Transglutaminase 2 interaction with small heat shock proteins mediate cell survival upon excitotoxic stress

Caccamo, D., Condello, S., Ferlazzo, N., Currò, M., Griffin, M. & Ientile, R., Jan 2013, In : Amino Acids. 44, 1, p. 151-159 9 p.

Research output: Contribution to journalArticle

Small Heat-Shock Proteins
N-Methylaspartate
Cell Survival
Cells
Transglutaminases

Transglutaminase 2 interacts with syndecan-4 and CD44 at the surface of human macrophages to promote removal of apoptotic cells

Nadella, V., Wang, Z., Johnson, T. S., Griffin, M. & Devitt, A., Jan 2015, In : BBA - Molecular Cell Research. 1853, 1, p. 201-212 12 p.

Research output: Contribution to journalArticle

File
Syndecan-4
Macrophages
Heparitin Sulfate
Cell Adhesion
transglutaminase 2

Transglutaminase 2 is involved in autophagosome maturation

D'Eletto, M., Farrace, M. G., Falasca, L., Reali, V., Oliverio, S., Melino, G., Griffin, M., Fimia, G. M. & Piacentini, M., 16 Nov 2009, In : Autophagy. 5, 8, p. 1145-1154 10 p.

Research output: Contribution to journalArticle

Autophagy
Organelles
Mitochondria
Protein Isoforms
Light

Transglutaminase 2 maintains a colorectal cancer stem phenotype by regulating epithelial-mesenchymal transition

Ayinde, O., Wang, Z., Pinton, G., Moro, L. & Griffin, M., 16 Jul 2019, In : Oncotarget. 10, 44, p. 4556-4569 14 p.

Research output: Contribution to journalArticle

Open Access
File
Epithelial-Mesenchymal Transition
Colorectal Neoplasms
Phenotype
Neoplastic Stem Cells
Vascular Endothelial Growth Factor A

Transglutaminase 2 null macrophages respond to lipopolysaccharide stimulation by elevated proinflammatory cytokine production due to an enhanced αvβ3 integrin-induced Src tyrosine kinase signaling

Sarang, Z., Köröskényi, K., Pallai, A., Duró, E., Melino, G., Griffin, M., Fésüs, L. & Szondy, Z., Jul 2011, In : Immunology Letters. 138, 1, p. 71-78 8 p.

Research output: Contribution to journalArticle

Open Access
File
src-Family Kinases
Integrins
Lipopolysaccharides
Macrophages
Cytokines

Transglutaminase and vascular biology: physiopathologic implications and perspectives for therapeutic interventions

Bergamini, C. M., Griffin, M. & Pansini, F. S., 2005, In : Current Medicinal Chemistry. 12, 20, p. 2357-2372 16 p.

Research output: Contribution to journalArticle

Transglutaminases
Matrix Metalloproteinases
Blood Vessels
Endothelial cells
Blood Coagulation

Transglutaminase inhibition ameliorates experimental diabetic nephropathy

Huang, L., Haylor, J. L., Hau, Z., Jones, R. A., Vickers, M. E., Wagner, B., Griffin, M., Saint, R. E., Coutts, I. G. C., El Nahas, A. M. & Johnson, T. S., Aug 2009, In : Kidney international. 76, 4, p. 383-394 12 p.

Research output: Contribution to journalArticle

File
Transglutaminases
Diabetic Nephropathies
Myofibroblasts
Cicatrix
Extracellular Matrix

Transglutaminase inhibition reduces fibrosis and preserves function in experimental chronic kidney disease

Johnson, T. S., Fisher, M., Haylor, J. L., Hau, Z., Skill, N. J., Jones, R., Saint, R., Coutts, I. G. C., Vickers, M. E., El Nahas, A. M. & Griffin, M., Dec 2007, In : Journal of the American Society of Nephrology. 18, 12, p. 3078-3088 11 p.

Research output: Contribution to journalArticle

Transglutaminases
Chronic Renal Insufficiency
Fibrosis
Extracellular Matrix
Collagen

Transglutaminase mediated grafting of silk proteins onto wool fabrics leading to improved physical and mechanical properties

Cortez, J., Anghieri, A., Bonner, P. L. R., Griffin, M. & Freddi, G., 1 Jun 2007, In : Enzyme and Microbial Technology. 40, 7, p. 1698-1704 7 p.

Research output: Contribution to journalArticle

Transglutaminases
Silk
Wool
Sericins
Physical properties

Transglutaminase overexpression sensitizes neuronal cell lines to apoptosis by increasing mitochondrial membrane potential and cellular oxidative stress

Piacentini, M., Farrace, M. G., Piredda, L., Matarrese, P., Ciccosanti, F., Falasca, L., Rodolfo, C., Giammarioli, A. M., Verderio, E., Griffin, M. & Malorni, W., Jun 2002, In : Journal of Neurochemistry. 81, 5, p. 1061-1072 12 p.

Research output: Contribution to journalArticle

Transglutaminases
Oxidative stress
Mitochondrial Membrane Potential
Oxidative Stress
Cells

Transglutaminases: nature's biological glues

Griffin, M., Casadio, R. & Bergamini, C. M., 1 Dec 2002, In : Biochemical Journal. 368, Pt 2, p. 377-396 20 p.

Research output: Contribution to journalArticle

Open Access
Transglutaminases
Glues
Adhesives
Enzymes
Tissue

Transglutaminases as tanning agents for the leather industry

Collighan, R., Clara, S., Li, X., Parry, J. & Griffin, M., Jul 2004, In : Journal of the American Leather Chemists Association. 99, 7, p. 293-302 10 p.

Research output: Contribution to journalArticle

Tanning
Transglutaminases
Leather
Crosslinking
Collagen

Transglutaminases in the leather industry

Collighan, R. & Griffin, M., Jan 2003, British Leather Technology Centre journal, 46.

Research output: Contribution to specialist publicationArticle

Transglutaminase transcription and antigen translocation in experimental renal scarring

Johnson, T. S., Skill, N. J., El Nahas, A. M., Oldroyd, S. D., Thomas, G. L., Douthwaite, J. A., Haylor, J. L. & Griffin, M., Oct 1999, In : Journal of the American Society of Nephrology. 10, 10, p. 2146-2157 12 p.

Research output: Contribution to journalArticle

Transglutaminases
Cicatrix
Kidney
Antigens
Lysine

Transglutaminase treatment of wool fabrics leads to resistance to detergent damage

Cortez, J., Bonner, P. L. R. & Griffin, M., 6 Apr 2005, In : Journal of Biotechnology. 116, 4, p. 379-386 8 p.

Research output: Contribution to journalArticle

Transglutaminases
Wool
Detergents
Laundries
Clothing

Unexpected role of surface transglutaminase type II in celiac disease

Maiuri, L., Ciacci, C., Ricciardelli, I., Vacca, L., Raia, V., Rispo, A., Griffin, M., Issekutz, T., Quaratino, S. & Londei, M., Nov 2005, In : Gastroenterology. 129, 5, p. 1400-1413 14 p.

Research output: Contribution to journalArticle

Celiac Disease
Gliadin
Organ Culture Techniques
T-Lymphocytes
Toxic Actions