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2019

Characterization and outcomes of spontaneous coronary artery dissection patients presenting with an acute coronary syndrome: insights from the Acalm Registry

Potluri, R., Carter, P., Aziz, A., Vo, M., More, R., Ahmed, A., Adlam, D., Welsh, R. & Bainey, K. R., 26 May 2019, In : Heart. 105, A137.

Research output: Contribution to journalMeeting abstract

Establishment of porcine and human expanded potential stem cells

Gao, X., Nowak-imialek, M., Chen, X., Chen, D., Herrmann, D., Ruan, D., Chen, A. C. H., Eckersley-maslin, M. A., Ahmad, S., Lee, Y. L., Kobayashi, T., Ryan, D., Zhong, J., Zhu, J., Wu, J., Lan, G., Petkov, S., Yang, J., Antunes, L., Campos, L. S. & 27 others, Fu, B., Wang, S., Yong, Y., Wang, X., Xue, S., Ge, L., Liu, Z., Huang, Y., Nie, T., Li, P., Wu, D., Pei, D., Zhang, Y., Lu, L., Yang, F., Kimber, S. J., Reik, W., Zou, X., Shang, Z., Lai, L., Surani, A., Tam, P. P. L., Ahmed, A., Yeung, W. S. B., Teichmann, S. A., Niemann, H. & Liu, P., 3 Jun 2019, In : Nature Cell Biology. 21, 6, p. 687-699 13 p.

Research output: Contribution to journalArticle

Open Access
File
Swine
Stem Cells
Blastomeres
Germ Layers
Induced Pluripotent Stem Cells

Pravastatin for early‐onset preeclampsia: a randomized, blinded, placebo‐controlled trial

Ahmed, A., Williams, D., Cheed, V., Middleton, L. J., Ahmad, S., Wang, K., Vince, A. T., Hewett, P., Spencer, K., Khan, K. S., Daniels, J. P., Barber, K., Kilby, M., Knox, E., Sellman, T., Trinham, P., Tuffnell, D., Jones, V., Syson, J., Shah, N. & 50 others, Deeks, L., Carter, W., Dorman, E., Thomas, S., Harrington, D., Higgins, N., Wilmott‐powell, M., Simpson, N., Dolby, V., Bricker, L., Walkinshaw, S., Houghton, G., Longworth, H., Williamson, C., Dhanjal, M., Noori, M., Machirori, M., Howard, R., Murray, R., Weist, S., Denison, F., Crawford, I., Robson, S., Allan, C., Myers, J., Bernatavicius, G., Moorhead, L., Chappell, L., Nelson‐piercy, C., Williams, D., Daley, R., Rosas, M., Greer, I., Vitek, L., Shennan, A., Marlow, N., Marie Barnard, A., Thornton, J., Rennie, J., Peacock, J., Gao Smith, F., Hyde, C., Crawford, I., Cudmore, M., Furmston, A., Fulcher, L., Homer, L., Howman, A., Hilken, N. & Brown, S., 12 Nov 2019, In : BJOG.

Research output: Contribution to journalArticle

Open Access
File
Pravastatin
Pre-Eclampsia
Tyrosine
Random Allocation
Placebos

Survival after cardiac resynchronization therapy: results from 50 084 implantations

Leyva, F., Zegard, A., Okafor, O., De Bono, J., Mcnulty, D., Ahmed, A., Marshall, H., Ray, D. & Qiu, T., 1 May 2019, In : Europace. 21, 5, p. 754–762 9 p.

Research output: Contribution to journalArticle

Open Access
File
Cardiac Resynchronization Therapy
Survival
Myocardial Ischemia
Confidence Intervals
Mortality
2018

333: Potential preeclampsia therapy tested

Ahmed, A., Wang, K., Ahmad, S. & Rezai, H., 3 Jan 2018, p. S208.

Research output: Contribution to conferencePoster

Hormone Replacement Therapy: Would it be Possible to Replicate a Functional Ovary?

Agarwal, S., Alzahrani, F. & Ahmed, A., 14 Oct 2018, In : International Journal of Molecular Sciences. 19, 10, 3160.

Research output: Contribution to journalArticle

Open Access
File
ovaries
hormones
Hormone Replacement Therapy
Hormones
Ovary

Soluble Fms-like tyrosine kinase-1 alters cellular metabolism and mitochondrial bioenergetics in preeclampsia

Sanchez Aranguren, L., Espinosa-González, C. T., González-Ortiz, L. M., Sanabria-Barrera, S. M., Riaño-Medina, C. E., Nuñez, A. F., Ahmed, A., Vasquez-Vivar, J. & López, M., 6 Mar 2018, In : Frontiers in Physiology. 9, 83.

Research output: Contribution to journalArticle

Open Access
File
Vascular Endothelial Growth Factor Receptor-1
Pre-Eclampsia
Energy Metabolism
Endothelial Cells
Trophoblasts
2017

Angiopoietin-1 promotes atherosclerosis by increasing the proportion of circulating Gr1+ monocytes

Fujisawa, T., Wang, K., Niu, X-L., Egginton, S., Ahmad, S., Hewett, P. W., Kontos, C. D. & Ahmed, A., 17 Oct 2017, In : Cardiovascular Research. 113, 1, p. 81-89 9 p.

Research output: Contribution to journalArticle

Open Access
File
Angiopoietin-1
Monocytes
Atherosclerosis
Apolipoproteins E
Adenoviridae

Development and validation of Prediction models for Risks of complications in Early-onset Pre-eclampsia (PREP): a prospective cohort study

Thangaratinam, S., Allotey, J., Marlin, N., Mol, B. W., von Dadelszen, P., Ganzevoort, W., Akkermans, J., Ahmed, A., Daniels, J., Deeks, J., Ismail, K., Barnard, A. M., Dodds, J., Kerry, S., Moons, C., Riley, R. D. & Khan, K. S., 30 Apr 2017, In : Health Technology Assessment. 21, 18, 130.

Research output: Contribution to journalReview article

Open Access
File
Pre-Eclampsia
Cohort Studies
Prospective Studies
Confidence Intervals
Mothers

Evidence-based revised view of the pathophysiology of preeclampsia

Ahmed, A., Rezai, H. & Broadway-Stringer, S., 2017, Hypertension: from basic research to clinical practice. Islam, M. S. (ed.). Cham (CH): Springer, Vol. 2. p. 355-374 20 p. (Advances in Experimental Medicine and Biology; vol. 956)(Advances in Internal Medicine).

Research output: Chapter in Book/Report/Conference proceedingChapter

Pre-Eclampsia
Oxidative stress
Angiogenesis Inducing Agents
Cystathionine
Hydrogen Sulfide

Heterodimerisation between VEGFR-1 and VEGFR-2 and not the homodimers of VEGFR-1 inhibit VEGFR-2 activity

Cai, M., Wang, K., Murdoch, C. E., Gu, Y. & Ahmed, A., Jan 2017, In : Vascular Pharmacology. 88, p. 11-20 10 p.

Research output: Contribution to journalArticle

Open Access
File
Vascular Endothelial Growth Factor Receptor-1
Vascular Endothelial Growth Factor Receptor-2
Phosphatidylinositol 3-Kinase
Vascular Endothelial Growth Factor A
Phosphorylation

In vivo hemin conditioning targets the vascular and immunologic compartments and restrains prostate tumor development

Jaworski, F. M., Gentilini, L. D., Gueron, G., Meiss, R. P., Ortiz, E. G., Berguer, P. M., Ahmed, A., Navone, N., Rabinovich, G. A., Compagno, D., Laderach, D. J. & Vazquez, E. S., 1 Sep 2017, In : Clinical Cancer Research. 23, 17, p. 5135-5148 14 p.

Research output: Contribution to journalArticle

Open Access
File
Hemin
Blood Vessels
Prostate
Heme Oxygenase-1
Neoplasms

Small molecule, big prospects: MicroRNA in pregnancy and its complications

Cai, M., Kolluru, G. K. & Ahmed, A., 20 Jun 2017, In : Journal of Pregnancy. 2017, 16 p., 6972732.

Research output: Contribution to journalReview article

Open Access
File
Pregnancy Complications
MicroRNAs
Pregnancy
Placenta
Small Untranslated RNA

Vascular endothelial growth factor signaling requires glycine to promote angiogenesis

Guo, D., Murdoch, C. E., Xu, H., Shi, H., Duan, D. D., Ahmed, A. & Gu, Y., 7 Nov 2017, In : Scientific Reports. 7, 1, p. 14749

Research output: Contribution to journalArticle

Open Access
File
Glycine
Vascular Endothelial Growth Factor A
Voltage-Dependent Anion Channel 1
Glycine Plasma Membrane Transport Proteins
Peripheral Vascular Diseases

Vesicle miR-195 derived from endothelial cells inhibits expression of serotonin transporter in vessel smooth muscle cells

Gu, J., Zhang, H., Ji, B., Jiang, H., Zhao, T., Jiang, R., Zhang, Z., Tan, S., Ahmed, A. & Gu, Y., 8 Mar 2017, In : Scientific Reports. 7, 10 p., 43546.

Research output: Contribution to journalArticle

Open Access
File
Serotonin Plasma Membrane Transport Proteins
Smooth Muscle Myocytes
Serotonin
Endothelial Cells
Physiological Phenomena
2016

A pilot study using laser-based technique for non-invasive diagnostics of hypertensive conditions in mice

Choi, B. (ed.), Kollias, N. (ed.), Zeng, H. (ed.), Kang, H. W. (ed.), Wong, B. J. F. (ed.), Ilgner, J. F. (ed.), Tearney, G. J. (ed.), Gregory, K. W. (ed.), Marcu, L. (ed.), Skala, M. C. (ed.), Campagnola, P. J. (ed.), Mandelis, A. (ed.), Morris, M. D. (ed.), Litvinova, K. S., Ahmad, S., Wang, K., Rafailov, I. E., Sokolovski, S. G., Zhang, L., Rafailov, E. U. & 1 others, Ahmed, A., 29 Feb 2016.

Research output: Contribution to conferenceOther

Open Access
File
Pre-Eclampsia
Lasers
Mothers
Equipment and Supplies
Aptitude

Hydrogen sulfide: a novel mechanism for the vascular protection by resveratrol under oxidative stress in mouse aorta

Yetik-Anacak, G., Sevin, G., Ozzayim, O., Dereli, M. V. & Ahmed, A., 1 Aug 2016, In : Vascular Pharmacology. In press

Research output: Contribution to journalArticle

Open Access
File
Hydrogen Sulfide
Blood Vessels
Aorta
Pyrogallol
Oxidative Stress

Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to the development of pulmonary arterial hypertension

Guo, D., Gu, J., Jiang, H., Ahmed, A., Zhang, Z. & Gu, Y., Feb 2016, In : Journal of Molecular and Cellular Cardiology. 91, p. 179-187 9 p.

Research output: Contribution to journalArticle

Open Access
File
Pyruvate Kinase
Pulmonary Hypertension
Reactive Oxygen Species
Pulmonary Artery
Smooth Muscle Myocytes

"Nucleosome debris" provokes coagulation and inflammation

Wegiel, B. & Ahmed, A., Jan 2016, In : Thrombosis Research. 137, p. 1-2 2 p.

Research output: Contribution to journalEditorial

Nucleosomes
Inflammation

Role of epithelial Na+ channels in endothelial function

Guo, D., Liang, S., Wang, S., Tang, C., Yao, B., Wan, W., Zhang, H., Jiang, H., Ahmed, A., Zhang, Z. & Gu, Y., 1 Jan 2016, In : Journal of Cell Science. 129, 2, p. 290-297 8 p.

Research output: Contribution to journalArticle

Open Access
File
Epithelial Sodium Channels
Endothelial Cells
Heme Oxygenase-1
Carbon Monoxide
Caveolae
2015

Carbon monoxide inhibits sprouting angiogenesis and vascular endothelial growth factor receptor-2 phosphorylation

Ahmad, S., Hewett, P. W., Fujisawa, T., Sissaoui, S., Cai, M., Gueron, G., Al-Ani, B., Cudmore, M., Ahmed, S. F., Wong, M. K. K., Wegiel, B., Otterbein, L. E., Vítek, L., Ramma, W., Wang, K. & Ahmed, A., 1 Feb 2015, In : Thrombosis and Haemostasis. 113, 2, p. 329-337 9 p.

Research output: Contribution to journalArticle

Vascular Endothelial Growth Factor Receptor-2
Carbon Monoxide
Phosphorylation
Fibroblast Growth Factor 2
Vascular Endothelial Growth Factor A

Diametrically opposed actions of the heme oxygenase-1 and endothelial nitric oxide synthase pathways in angiogenesis via p21WAF1

Cai, M., Al-Ani, B., Fujisawa, T., Ahmad, S. & Ahmed, A., 13 Mar 2015, In : Reproductive Sciences. 22, Suppl.1, p. A282 1 p., F-247.

Research output: Contribution to journalMeeting abstract

Heme Oxygenase-1
Nitric Oxide Synthase Type III
Fibroblast Growth Factor 2
Vascular Endothelial Growth Factor A
Intercellular Signaling Peptides and Proteins

Drug repurposing screen identifies Foxo1-dependent angiopoietin-2 regulation in sepsis

Ghosh, C. C., Thamm, K., Berghelli, A. V., Schrimpf, C., Maski, M. R., Abid, T., Milam, K. E., Rajakumar, A., Santel, A., Kielstein, J. T., Ahmed, A., Thickett, D., Wang, K., Chase, M., Donnino, M. W., Aird, W. C., Haller, H., David, S. & Parikh, S. M., Jul 2015, In : Critical Care Medicine. 43, 7, p. e230-e240 11 p.

Research output: Contribution to journalArticle

Open Access
File
Drug Repositioning
Angiopoietin-2
Sepsis
Simvastatin
Hydroxymethylglutaryl-CoA Reductase Inhibitors

Dysregulation of placental cystathionine-β-synthase impact on fetal growth restriction

Wang, K., Cai, M., Ahmad, S. & Ahmed, A., 13 Mar 2015, In : Reproductive Sciences. 22, Suppl.1, p. A195 1 p., T-276.

Research output: Contribution to journalMeeting abstract

Cystathionine
Fetal Development
Aminooxyacetic Acid
First Pregnancy Trimester
Pre-Eclampsia

Dysregulation of placental cystathionine-β-synthase promotes fetal growth restriction

Wang, K., Cai, M., Abu-Alkheir, W., Ahmad, S. & Ahmed, A., 1 May 2015, In : Nitric Oxide. 47, Suppl.1, p. S57-S58 2 p., PP108.

Research output: Contribution to journalMeeting abstract

Cystathionine
Fetal Development
Pre-Eclampsia
Aminooxyacetic Acid
Lyases

Glutaredoxin-1 Is up-regulated in preeclampsia and increases soluble Flt-1 expression

Murdoch, C. E., Georgiadou, A., Bartkeviciute, M., Broadway-Stringer, S. & Ahmed, A., Mar 2015, In : Reproductive Sciences. 22, Suppl.1, p. A203-A204 2 p., T-302.

Research output: Contribution to journalMeeting abstract

Glutaredoxins
Pre-Eclampsia
Placenta
Oxidation-Reduction
Cysteine

Hydrogen sulphide rescues preeclampsia-like phenotype aggravated by high sFlt-1 in placenta growth factor (PlGF) deficiency

Ahmad, S., Wang, K., Egginton, S., Hewett, P. W. & Ahmed, A., 1 May 2015, In : Nitric Oxide. 47, Suppl.1, p. S27-S28 2 p., PP36.

Research output: Contribution to journalMeeting abstract

Hydrogen Sulfide
Pre-Eclampsia
Intercellular Signaling Peptides and Proteins
Phenotype
Blood pressure

Hydrogen sulphide rescues preeclampsia-like phenotype aggravated by high sFlt-1 in Placenta Growth Factor (PlGF) deficiency

Ahmad, S., Ma, B., Wang, K., Hewett, P., Egginton, S. & Ahmed, A., 13 Mar 2015, In : Reproductive Sciences. 22, Suppl.1, p. A94 1 p., O-117.

Research output: Contribution to journalMeeting abstract

Hydrogen Sulfide
Pre-Eclampsia
Phenotype
Fetal Resorption
Arterial Pressure

Preeclampsia : an accelerator–brake defect disorder

Ahmed, A., Ahmad, S. & Wang, K., 1 May 2015, In : Nitric Oxide. 47, Suppl.1, p. S9 1 p., OP14.

Research output: Contribution to journalArticle

Pre-Eclampsia
Vascular Endothelial Growth Factor A
Hydrogen Sulfide
Carbon Monoxide
Defects

Resveratrol stimulates hydrogen sulfide (H2S) formation to relax murine corpus cavernosum

Yetik-Anacak, G., Dereli, M. V., Sevin, G., Ozzayim, O., Erac, Y. & Ahmed, A., 31 Oct 2015, In : Journal of Sexual Medicine. 12, 10, p. 2004-2012 9 p.

Research output: Contribution to journalArticle

Hydrogen Sulfide
Cysteine
Cystathionine gamma-Lyase
Erectile Dysfunction
resveratrol

The impact of statin use on fetal development: a meta-analysis

Abbas, A. S., Morton, S., Shun-Shun, M., Raman, S., Thangaratinam, S. & Ahmed, A., 13 Mar 2015, In : Reproductive Sciences. 22, Suppl.1, p. A169 1 p., T-192.

Research output: Contribution to journalMeeting abstract

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Fetal Development
Meta-Analysis
Pregnancy
Databases

The role of H2S bioavailability in endothelial dysfunction

Wang, R., Szabo, C., Ichinose, F., Ahmed, A., Whiteman, M. & Papapetropoulos, A., 2015, In : Trends in Pharmacological Sciences. 36, 9, p. 568-578 11 p.

Research output: Contribution to journalArticle

Endothelial cells
Biological Availability
Endothelial Cells
Hydrogen Sulfide
Pathology

Unravelling the theories of pre-eclampsia: Are the protective pathways the new paradigm?

Ahmed, A. & Ramma, W., Mar 2015, In : British Journal of Pharmacology. 172, 6, p. 1574-1586 13 p.

Research output: Contribution to journalArticle

Open Access
File
Pre-Eclampsia
Inflammation
Pregnancy
Oxidative Stress
Angiogenesis Inducing Agents